中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

134 records (took 0.013 seconds)

    Methods and apparatus for detecting biological activities in a specimen
    71.
    发明公开
    Methods and apparatus for detecting biological activities in a specimen 失效
    一种用于在样品检测的生物活性的方法和装置。

    公开(公告)号：EP0567231A3

    公开(公告)日：1995-04-12

    申请号：EP93302292.3

    申请日：1993-03-25

    Applicant: Becton Dickinson and Company

    Inventor： Berndt, Klaus W. ,  Gladnick, Paul C. ,  Berger, Dolores M.

    IPC: C12M1/34 ,  G01N21/51

    CPC classification number: G01N21/253 ,  C12M41/36 ,  G01N21/51 ,  G01N2021/4709 ,  G01N2201/062 ,  G01N2201/0833 ,  Y10S435/808

    Abstract: Methods and apparatus for detecting biological activities in a specimen such as blood are disclosed. The present invention provides a system whereby the intensity of light with a wavelength within the range of about 600 nm to 800 nm introduced into a sample at a first location is measured as it reemerges at a second location. A significant change in the intensity of the reemerging light indicates the presence of biological activity. Preferably, the intensity is also measured at a fourth location, or alternatively, a second light source is disposed at a third location to permit comparative intensity data to be collected. These data are useful in partially identifying the types of microorganisms present in the sample. In preferred embodiments, light emitting diodes are used as the light sources and multiplexed to a plurality of samples. These signals are either detected using photodetectors and demultiplexed, or are collected using fiber-optic light guides and fed to a photomultiplier tube which generates an intensity signal. In either embodiment, the intensity signal is preferably amplified, digitized and stored in a computer.

    Optical analytical instrument and method
    72.
    发明公开
    Optical analytical instrument and method 失效
    Optisches分析仪

    公开(公告)号：EP0480753A2

    公开(公告)日：1992-04-15

    申请号：EP91309385.2

    申请日：1991-10-11

    Applicant: TYTRONICS, INC.

    Inventor： Sayegh, Emile ,  Mooney, Eric F.

    IPC: G01N21/31 ,  G01N21/53 ,  G01N21/85 ,  G01N21/25 ,  G01N21/27 ,  G01J3/42

    CPC classification number: G01N21/85 ,  G01N21/274 ,  G01N21/314 ,  G01N21/532 ,  G01N2201/0826 ,  G01N2201/0833

    Abstract: Optical analytical instruments to determine a physical parameter of a fluid, and methods of operation of such instruments, are shown. These employ a source of suitable optical radiation, a detector means, means defining a zone for the fluid, means defining an optical path from the radiation source through the fluid zone to the detector means, and reading and control circuitry. At least two readings of optical energy that has been influenced by the fluid are taken without there having occurred substantial change to the fluid. During one of the readings a filter of known absorbance is included in the optical path so that the respective reading represents a calibration reading. A calibration-value-determining means is constructed first to compare, effectively, the two readings to remove the effect of the fluid from the value of the calibration reading, second, to compare, effectively the residual value of the calibration reading to a known value based on the known absorbance of the filter, and, third, on the basis of the second comparison, to make a calibration adjustment based on values derived while the fluid sample remained unchanged in the fluid zone. Novel software implementations of the determinations are shown. Specific examples of instruments and methods implementing these features shown are a dual lamp, no-moving part in-line spectrophotometer, a no-moving part reflection colorimeter capable of on-line or off-line operation, a scatter or fluorescence detecting implementation and a turbidimeter.

    Abstract translation: 显示了用于确定流体的物理参数的光学分析仪器以及这些仪器的操作方法。 这些采用合适的光辐射源，检测器装置，限定流体区域的装置，限定从辐射源通过流体区到检测器装置的光路，以及读和控制电路。 已经受到流体影响的光能的至少两次读数没有发生实际的流体变化。 在读数之一期间，光路中包含已知吸光度的滤光器，使得各自的读数表示校准读数。 首先构建校准值确定装置，以有效地比较两个读数，以从校准读数的值中除去流体的影响，其次，将校准读数的残差值有效地与已知值进行比较 基于过滤器的已知吸光度，以及第三，基于第二比较，基于流体样本在流体区域中保持不变而导出的值进行校准调整。 显示了确定的新型软件实现。 实现这些特征的仪器和方法的具体实例是双灯，不运动部分在线分光光度计，能够在线或离线操作的无移动部分反射比色计，散射或荧光检测实现和 浊度仪。

    FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME
    77.
    发明公开
    FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME 有权
    流式细胞模块和液体样品分析仪及包含该方法的方法

    公开(公告)号：EP3169988A2

    公开(公告)日：2017-05-24

    申请号：EP15778417.4

    申请日：2015-09-15

    Applicant: PerkinElmer Health Sciences, Inc.

    Inventor： DICESARE, Joseph L. ,  JIN, Feng ,  NEAL, Timothy P. ,  AIKENS, David

    IPC: G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01J3/44

    CPC classification number: G01J3/0202 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/0389 ,  G01N2021/6417 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0642 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/262

    Abstract: A flow cell for a fluorescence spectrometer includes a flow channel to receive a flow of a liquid sample, an excitation light entrance window to receive excitation light from a light source, and an emission light exit window to transmit fluorescent emission light from the liquid sample in the flow channel from the flow cell. The excitation light entrance window and/or emission light exit window includes a waveguide including: a waveguide core formed of a core material; and a cladding medium surrounding a portion of the waveguide core, wherein the cladding medium has a refractive index less than the refractive index of the core material. The waveguide defines a portion of the flow channel.

    Abstract translation: 本发明提供一种荧光光谱仪用流动池，其具有接受液体试样的流动的流路，接收来自光源的激励光的激励光入射窗以及使来自液体试样的荧光放射光透过的射出光出射窗， 来自流动池的流动通道。 激发光入射窗和/或发射光出射窗包括波导，波导包括：由芯材形成的波导芯; 以及围绕波导芯的一部分的包层介质，其中包层介质的折射率小于芯材的折射率。 波导限定流动通道的一部分。

Patent Agency Ranking