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    COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF
    75.
    发明公开
    COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF 审中-公开

    公开(公告)号：EP3119899A4

    公开(公告)日：2017-11-29

    申请号：EP15764217

    申请日：2015-03-20

    申请人： SYNTHETIC GENOMICS INC

    发明人： KAMBOURAKIS SPIROS ,  GRIFFIN BENJAMIN M ,  MARTIN KEVIN V

    IPC分类号： C12P7/58 ,  C12N9/04 ,  C12P7/42 ,  C12P7/44 ,  C12P17/04 ,  C12P17/06

    CPC分类号： C12P7/58 ,  C12P7/44 ,  C12P17/06

    摘要： The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention.

    PROCESS FOR THE PREPARATION OF 2,5-FURANDICARBOXYLIC ACID
    76.
    发明授权
    PROCESS FOR THE PREPARATION OF 2,5-FURANDICARBOXYLIC ACID 有权
    制备2,5-呋喃甲酸的方法

    公开(公告)号：EP3013969B1

    公开(公告)日：2017-08-09

    申请号：EP14737042.3

    申请日：2014-06-20

    申请人： Technische Universiteit Delft

    发明人： VAN SPRONSEN, Jacob ,  WITKAMP, Geert-Jan ,  DE GRAAFF, Bart

    IPC分类号： C12P17/04 ,  C07D307/68

    CPC分类号： C12P17/04 ,  C07D307/68

    摘要： The invention is directed to a process for the preparation of 2,5-furandicarboxylic acid (FDCA) by fermentation comprising fermenting a suitable starting compound to produce an aqueous solution of a salt of FDCA having a pH of at least 7, optionally removing solids from said solution, e.g. by filtration, subsequently freeze crystallizing the said salt of FDCA from said solution at said pH, isolating the said FDCA salt in the form of solid crystals, preparing an aqueous solution of said salt and crystallizing FDCA as the free acid from said solution at an acidic pH.

    摘要翻译： 本发明涉及通过发酵制备2,5-呋喃二甲酸（FDCA）的方法，其包括发酵合适的起始化合物以产生pH为至少7的FDCA盐的水溶液，任选地从 所述解决方案，例如， 通过过滤，随后在所述pH下从所述溶液冷冻结晶FDCA的所述盐，以固体晶体的形式分离所述FDCA盐，制备所述盐的水溶液，并将FDCA以游离酸的形式在所述溶液中以酸性 pH值。

    PROCÉDÉ DE TRANSFORMATION DE LÉVOGLUCOSÉNONE EN 4-HYDROXYMÉTHYLBUTYROLACTONE OU 4-HYDROXYMÉTHYLBUTÉNOLIDE
    77.
    发明公开
    PROCÉDÉ DE TRANSFORMATION DE LÉVOGLUCOSÉNONE EN 4-HYDROXYMÉTHYLBUTYROLACTONE OU 4-HYDROXYMÉTHYLBUTÉNOLIDE 审中-公开
    VERFAHREN ZUR UMWANDLUNG VON LEVOGLUCOSENON在4-羟基甲基丁内酯四羟基甲基硬脂酸

    公开(公告)号：EP3137617A1

    公开(公告)日：2017-03-08

    申请号：EP15720056.9

    申请日：2015-04-29

    申请人： Institut National de la Recherche Agronomique ,  Institut des Sciences et Industries du Vivant et de l'Environnement

    发明人： ALLAIS, Florent ,  FLOURAT, Amandine ,  PERU, Aurélien ,  TEIXEIRA, Andreia ,  BRUNISSEN, Fanny ,  SPINNLER, Henry Eric

    IPC分类号： C12P17/04

    CPC分类号： C12P17/04

    摘要： The invention relates to a method for transforming levoglucosenone into 4-hydroxymethyl butyrolactone or 4-hydroxymethyl butenolide, comprising a step involving the oxidation of the levoglucosenone, or dihydrolevoglucosenone obtained by hydrogenation of levoglucosenone, by bringing a solution of levoglucosenone or dihydrolevoglucosenone in a solvent into contact with a lipase in the presence of an oxidizing agent and an acyl donor compound. The oxidation step is followed by a step involving the hydrolysis of the reaction mixture obtained, and, if necessary, a step involving the hydrogenation of the compound obtained at the end of the hydrolysis step.

    摘要翻译： 本公开涉及将左旋葡萄糖酮转化为4-羟甲基丁内酯或4-羟甲基丁烯内酯的方法，其包括通过将左旋葡萄糖酮或二氢氯代葡萄糖酮在溶剂中的溶液引入到左旋葡萄糖酮的氢化中而获得的左旋葡萄糖酮或通过氢化左旋葡萄糖酮得到的二氢氯吡啶酮的步骤 在氧化剂和酰基供体化合物的存在下与脂肪酶接触。 氧化步骤之后是所获得的反应混合物的水解步骤，必要时涉及在水解步骤结束时获得的化合物氢化的步骤。