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136 条记录 (耗时 0.048 秒)

    HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR IMPROVING PAPER STRENGTH
    82.
    发明公开
    HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR IMPROVING PAPER STRENGTH 审中-公开
    HYDRO READ，编码核酸体和法提高纸的强度

    公开(公告)号：EP1869173A2

    公开(公告)日：2007-12-26

    申请号：EP06748332.1

    申请日：2006-03-08

    申请人： Verenium Corporation

    发明人： KEROVUO, Janne, S. ,  MCCANN, Ryan ,  WEINER, David ,  SOLBAK, Arne, I., Jr.

    IPC分类号： C12N9/42

    CPC分类号： C12P7/6454 ,  C11C1/045 ,  C11C3/08 ,  C11C3/10 ,  C12N9/16 ,  C12N9/20 ,  C12P7/62 ,  C12P7/6418 ,  C12P7/6427 ,  Y10T442/20

    摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). In another aspect, the invention provides methods for hydrolyzing steryl esters and triglycerides (e.g., in a paper pulp), into sterols, glycerol and free fatty acids, using enzyme(s) of the invention. The invention provides enzymes and methods for decreasing the amount of lipophilic extracts ('pitch') in a pulp- comprising composition. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals.

    TRANSFERASES AND OXIDOREDUCTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    84.
    发明授权
    TRANSFERASES AND OXIDOREDUCTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
    转移酶，和氧化还原酶，用于生产和使用的核酸编码AND METHOD

    公开(公告)号：EP2238242B1

    公开(公告)日：2014-11-26

    申请号：EP08869698.4

    申请日：2008-12-31

    申请人： Verenium Corporation

    发明人： WEINER, David ,  LUGINBUHL, Peter ,  BUENO, Analia ,  CUENCA, Joslin ,  MARASCO, Erin

    IPC分类号： C12N9/10 ,  C12N9/02 ,  C12Q1/48 ,  C12Q1/26 ,  C07K14/38 ,  C07K16/40 ,  C07K9/00 ,  A61K38/44 ,  A61K38/45

    CPC分类号： C12N9/1096 ,  A21D8/042 ,  A61K38/00 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0014 ,  C12N9/10 ,  C12N15/1137 ,  C12N15/63 ,  C12N15/86 ,  C12P7/10 ,  C12Q1/6876 ,  C12Y206/01021 ,  D06L4/40 ,  D06M16/003 ,  G01N33/573 ,  Y02E50/16 ,  Y02P20/52 ,  Y02T50/678

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine + 2-oxoglutarate pyruvate + D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid + H 2 O + acceptor a 2-oxo acid + NH 3 + reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明涉及基因的反弹到酶，多核苷酸更具体编码酶，使用搜索多核苷酸和多肽的，并具有转移酶活性，例如转氨酶活性，例如d-氨基酸酸转移酶活性，和/或氧化还原酶活性，例如酶 脱氢酶活性，例如，Damino酸脱氢酶活性，和/或催化化学基团的转移，催化转氨基，催化反应：D-丙氨酸+ 2-酮戊二酸丙酮酸<=> + D-谷氨酸，和/或催化 到氧化还原反应，催化除去氢原子的，和/或催化下列反应：D-氨基酸+ H 2 O +受体<=> 2-含氧酸+ NH 3 +还原的受体。 因此，本发明提供的酶，组合物，方法用于制备药物组合物，医药中间体，抗生素，甜味剂，肽酶，肽类激素，燃料，燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆，和洗涤剂包括以本发明在雅舞蹈的多肽或多核苷酸。

    Phytases, nucleic acids encoding them and methods for making and using them
    85.
    发明公开
    Phytases, nucleic acids encoding them and methods for making and using them 有权
    肌醇六磷酸酶，核酸编码这些，以及它们的制备和使用过程

    公开(公告)号：EP2698374A1

    公开(公告)日：2014-02-19

    申请号：EP13175992.0

    申请日：2010-05-20

    申请人： Verenium Corporation

    发明人： Weiner, David ,  Solbak, Arne ,  McCann, Ryan

    IPC分类号： C07H21/04

    CPC分类号： C12N9/16 ,  Y02E50/17 ,  Y10T428/2982

    摘要： This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The invention further provides phytases which have increased gastric lability. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like. In one aspect, phytases of the invention are stabile against thermal denaturation during pelleting; and this decreases the cost of the phytase product while maintaining in vivo efficacy and detection of activity in feed.

    摘要翻译： 本发明涉及肌醇六磷酸酶，编码它们的多核苷酸，使用该多核苷酸和本发明的多肽，以及寻求多核苷酸和多肽的生产和分离的。 特别地，本发明提供具有多肽植酸酶活性高的温度条件下，和肌醇六磷酸酶没有暴露于高温后保持活性。 本发明提供这些都增加了胃的不稳定性进一步植酸酶。 本发明的肌醇六磷酸酶可以在食品中使用，以提高富植酸盐成分的供给值。 本发明的肌醇六磷酸酶可被配制为食品或饲料或补充剂要么到，E. G.，有助于植酸盐的消化。 本发明的食品或饲料可以是丸剂，液体，粉末等的形式。 在一个方面，本发明的肌醇六磷酸酶是反对造粒过程中的热变性稳定; 这降低了肌醇六磷酸酶的产物，而在体内效力和在进料活性的检测维护成本。