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    APPARATUS FOR DIGITAL IMAGING IN THE HEAD REGION OF A PATIENT
    81.
    发明公开
    APPARATUS FOR DIGITAL IMAGING IN THE HEAD REGION OF A PATIENT 审中-公开

    公开(公告)号：EP3603524A1

    公开(公告)日：2020-02-05

    申请号：EP19179134.2

    申请日：2019-06-07

    申请人： De Gotzen S.r.l.

    发明人： GIANI. Claudio ,  ROTONDO, Giuseppe ,  NETTIS, Costantino ,  VENTURINO, Gianfranco ,  RINALDI, Gerardo

    IPC分类号： A61B6/14 ,  A61B6/00

    摘要： An apparatus for Digital Imaging in the Head Region of a Patient is disclosed comprising:
    - a source (9) for generating X-ray radiation;
    - a sensor (11) for detecting X-ray radiation, which is generated by the source (9) and passes through a patient (14);
    - a rotary arm (6) for arranging the source (9) and the sensor (11) thereon in such a way as to be opposed to each other, wherein the rotary arm (6) is provided with adjustment means (10, 12) for varying the distance between the source (9) and the sensor (11);
    - a supporting structure (2, 3, 4, 5) for supporting the rotary arm (6), wherein motor driven translation and rotation means (7) are interposed between the rotary arm (6) and the supporting structure (2, 3, 4, 5),
    wherein
    - the apparatus comprises a control unit (16), that controls the source (9), the sensor (11), the adjustment means (10, 12), and the translation and rotation means (7) and that is arranged for operating the apparatus in various operation modes comprising different distances between source (9) and sensor (11), and wherein
    - the apparatus is provided with collision detection means (93, 94) connected with the control unit (16) and arranged for detecting a possible collision of the source (9) and/or sensor (11) with the patient (14) during the motion of the source (9) and/or sensor (11).

    APPARATUS FOR DIGITAL IMAGING IN THE HEAD REGION OF A PATIENT
    82.
    发明公开
    APPARATUS FOR DIGITAL IMAGING IN THE HEAD REGION OF A PATIENT 审中-公开

    公开(公告)号：EP3603523A1

    公开(公告)日：2020-02-05

    申请号：EP19179132.6

    申请日：2019-06-07

    申请人： De Gotzen S.r.l.

    发明人： GIANI, Claudio ,  ROTONDO, Giuseppe ,  NETTIS, Costantino ,  VENTURINO, Gianfranco ,  RINALDI, Gerardo

    IPC分类号： A61B6/14 ,  A61B6/00

    摘要： An apparatus for Digital Imaging in the Head Region of a Patient is disclosed comprising:
    - a source (9) for generating X-ray radiation;
    - a sensor (11) for detecting X-ray radiation, which is generated by the source (9) and passes through a patient (14);
    - a rotary arm (6) for arranging the source (9) and the sensor (11) thereon in such a way as to be opposed to each other, wherein the rotary arm (6) is provided with adjustment means (10, 12) for varying the distance between the source (9) and the sensor (11);
    - a supporting structure (2, 3, 4, 5) for supporting the rotary arm (6), wherein motor driven translation and rotation means (7) are interposed between the rotary arm (6) and the supporting structure (2, 3, 4, 5),

    wherein
    - the apparatus comprises a single sensor (11) for both panoramic imaging and computed tomography, and that
    - the apparatus comprises a control unit (16), that controls the source (9), the sensor (11), the adjustment means (10, 12), and the translation and rotation means (7) and that is arranged for operating the apparatus in a basic operation mode for bigger patients and in an alternative operation mode for smaller patients, in which the distance between the source (9) and the sensor (11) is reduced as compared to the distance used for the basic operation mode.

    FIBER OPTIC LIGHT SOURCE
    85.
    发明公开
    FIBER OPTIC LIGHT SOURCE 审中-公开
    光纤光源

    公开(公告)号：EP3279556A1

    公开(公告)日：2018-02-07

    申请号：EP17184972.2

    申请日：2017-08-04

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： Neuberger, Wolfgang ,  Solomatin, Alexey

    IPC分类号： F21V8/00 ,  G02B6/42 ,  H04B10/114

    CPC分类号： F21K9/64 ,  G02B6/0003 ,  G02B6/0006 ,  G02B6/0008 ,  G02B6/001 ,  G02B6/02076 ,  G02B6/0208 ,  G02B6/421 ,  G02B6/4214 ,  G02B27/0994 ,  H01S3/067 ,  H04B10/114 ,  H04B10/116

    摘要： A fiber optic light source in which input light with short and narrow band wavelength is converted/transformed into multi-band visible white light with high intensity output power is provided. The new light source comprises at least one homogenizing light guide element, and at least one photoluminescence element. It may also comprise at least one input element and an optical fiber. All or some of the elements may be integrated into an optical waveguide. In some embodiments the at least one input element increases light transfer efficiency from a ray source to the at least one homogenizing light guide element component of the fiber optic light source. The at least one photoluminescence element can be a point or an extended form like a line or surface. The fiber optic light source output beam may also contain the input ray wavelength, which in turn can be from a fiber optic laser. In operation an input ray travels through at least one homogenizing light guide element and irradiates at least one photoluminescence element present in preselected positions of the device to cause large area or spacious illumination at a desired target. This source can be an information source to communicate information through light modulation not noticeable to the naked human eye. Information is sent from the optical light source to information receivers, technical devices like smart phones, TV-Displays, or other devices, which could replace the common use of LAN or WLAN networks. Here a known luminescent detector can be used to efficiently collect the information in its optical form and to lead it to a suitable photo detector. This enables free-space optical light information transfer especially in areas where traditional infrastructure using transmitting fibers is difficult to establish.

    摘要翻译： 提供一种光纤光源，其中具有短波和窄波段波长的输入光被转换/变换成具有高强度输出功率的多波段可见白光。 新的光源包括至少一个均化光导元件和至少一个光致发光元件。 它也可以包括至少一个输入元件和光纤。 所有或一些元件可以被集成到光波导中。 在一些实施例中，所述至少一个输入元件增加从光源到光纤光源的至少一个均化光导元件部件的光传输效率。 该至少一个光致发光元件可以是像线或表面那样的点或扩展形式。 光纤光源输出光束也可以包含输入光线的波长，其又可以来自光纤激光器。 在操作中，输入射线穿过至少一个均化光导元件并且照射存在于装置的预选位置中的至少一个光致发光元件，以在期望的目标处引起大面积或宽敞的照明。 这个信息源可以作为一个信息来源，通过光线调制来传递信息，这对于肉眼来说并不明显。 信息从光源发送到信息接收器，技术设备如智能手机，电视显示器或其他设备，这些设备可以取代LAN或WL​​AN网络的常见用途。 这里可以使用已知的发光检测器来有效地收集其光学形式的信息并将其引导至合适的光电检测器。 这使得自由空间光信息传输成为可能，特别是在使用传输光纤的传统基础设施难以建立的地区。

    Method, network of reference stations and mobile navigation device for determining at least one real valued parameter of a receiver, in particular an absolute or relative position of the receiver, by means of a satellite navigation system
    86.
    发明授权
    Method, network of reference stations and mobile navigation device for determining at least one real valued parameter of a receiver, in particular an absolute or relative position of the receiver, by means of a satellite navigation system 有权
    方法，参考站和移动导航设备的网络，用于通过卫星导航系统确定接收机的至少一个实值参数，特别是接收机的绝对或相对位置

    公开(公告)号：EP2759849B1

    公开(公告)日：2018-01-17

    申请号：EP13152931.5

    申请日：2013-01-28

    申请人： Technische Universität München

    发明人： Brack, Andreas ,  Henkel, Patrick

    IPC分类号： G01S19/44

    CPC分类号： G01S19/44

    摘要： A method for determining at least one real-valued parameter, in particular an absolute or relative position of a receiver is proposed. The method uses a satellite navigation system comprising a plurality of satellites, which emit navigation signals on carrier signals. The method comprises the steps: - phase measurements on the carriers of the navigation signals are performed (12), - a real-valued float solution for at least one real-valued parameter and for phase ambiguities of the phase measurements and a corresponding covariance matrix are determined, - a sequential resolution of the phase ambiguities is performed, wherein a particular ambiguity to be resolved is mapped on a fixed ambiguity in dependency of the previously fixed ambiguities, wherein the mapping of a particular ambiguity to be resolved to the fixed ambiguity is performed by setting the fixed ambiguity equal to a weighted sum of integer candidates for the particular ambiguity, and - the float solution of the at least one real-valued parameter is adjusted to the fixed ambiguities

    CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY
    90.
    发明公开
    CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY 审中-公开
    卟啉类光敏剂与甘油基聚合物共轭用于光动力疗法

    公开(公告)号：EP3210626A1

    公开(公告)日：2017-08-30

    申请号：EP17158001.2

    申请日：2017-02-24

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： STAEGEMANN, Michael ,  HAAG, Rainer ,  WIEHE, Arno ,  GRÄFE, Susanna ,  GITTER, Burkhard ,  ALBRECHT, Volker

    IPC分类号： A61K41/00 ,  C07D403/14 ,  A61P35/00

    CPC分类号： C07D487/22 ,  A61K41/0071 ,  A61K47/60 ,  C07D403/14 ,  C08G65/48

    摘要： Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. In addition, conjugates are provided in which these photosensitizers are attached to water-soluble polymers via cleavable linkers that can be cleaved in the body under specific conditions. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

    摘要翻译： 可用作诊断和治疗应用的光敏剂的生物活性化合物，特别是用于癌症的PDT，感染和其他过度增殖性疾病，非肿瘤性适应症如关节炎，炎性疾病，病毒或细菌感染的荧光诊断和PDT治疗， 提供皮肤病，眼科或泌尿系统疾病以及提供获得药物质量的方法。 此外，提供了这样的缀合物，其中这些光敏剂经由可在特定条件下在体内裂解的可切割连接物连接至水溶性聚合物。 另一个实施方案包括将所需的四吡咯光敏剂配制成药物制剂以注射到体内，避免不希望的效应，例如四吡咯系统的溶解度问题或延迟的药代动力学。