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147 条记录 (耗时 0.014 秒)

    Process for the preparation of L-carnitine
    81.
    发明公开
    Process for the preparation of L-carnitine 失效
    制备L-卡尼汀的方法

    公开(公告)号：EP0210672A3

    公开(公告)日：1987-07-29

    申请号：EP86200864

    申请日：1986-05-20

    申请人： SCLAVO S.p.A.

    发明人： Casati, Paolo ,  Fuganti, Claudio

    IPC分类号： C07C85/04 ,  C07C101/12 ,  C07C99/04 ,  C07C101/30

    CPC分类号： C07C229/22

    摘要： A process is disclosed for the preparation of β-hydroxy-γ-trimethylamino-butyric acid (L-carnitine)
    wherein
    a) the compound diketene having formula:
    is reacted with chlorine, and the chlorination product thus obtained is submitted to amidation by the methylester of an optically-active aminoacid, having formula: wherein R = CH 2 A r or A r is a substitued or not- substituted aromatic group, to yield the compound 4-chloro-3-ketobutyrylamide of the methylester of the optically-active aminoacid:
    wherein R has the above reported meaning, b) the compound (IV) is reduced in the presence of a reducing agent to yield the compound
    wherein R has the above reported meaning, in the form of a mixture of (3R)-4-chloro-3-hydrox- ybutyrylamide of the methylester of an optically-active acid (VI), and (3S)-4-chloro-3-hydrox- ybutyrylamide of the methylester of an optically active aminoacid (VII), c) the compound (3R)-4-chloro-3-hydrox- ybutyrylamide of the methylester of an optically-active aminoacid (VI) is separated and recovered from the reduction reaction product, d) the compound (VI) is submitted to methanolysis by hydrogen chloride gas in methanol, e) the methylester of the optically-active aminoacid (III) is precipitated and recovered from the methanolysis reaction product, f) from the mother liquors the compound methylester of (3R)-4-chloro-3-hydroxybutyric acid having formula
    is recovered, g) the compound (VIII) thus obtained is treated with trimethylamine in ethanol, is hydrolyzed with hydro chloric acid and the compound L-carnitine (I) is separated and recovered.

    Process for the extraction and purification of alfa1-antitrypsin (alfa1-pI) from cohn IV-1 fraction
    85.
    发明公开
    Process for the extraction and purification of alfa1-antitrypsin (alfa1-pI) from cohn IV-1 fraction 失效
    Verfahren zur Extraktion und Reinigung von Alpha-1-Antitypypsin（alpha 1-pI）aus Cohnischer Fraktion IV-1

    公开(公告)号：EP0717049A1

    公开(公告)日：1996-06-19

    申请号：EP94119902.8

    申请日：1994-12-16

    申请人： SCLAVO S.p.A. ,  AIMA-DERIVATI S.p.A.

    发明人： Arrighi, Silvana ,  Bardotti, Angela ,  Bucci, Enzo

    IPC分类号： C07K14/81

    CPC分类号： C07K14/8121

    摘要： It is described a process for the extraction and following purification of alfa1-antitrypsin (alfa1-pI) from Cohn IV-1 Fraction, such process comprising the following steps:

    a) solubilization of the starting paste constituted by Cohn IV-1 Fraction and fractioned precipitation;
    b) hydrophobic interaction chromatography;
    c) viral inactivation; and
    d) final operations.

    摘要翻译： 描述了从Cohn IV-1馏分中提取和纯化α-1-抗胰蛋白酶（α-1-pI）的方法，该方法包括以下步骤：a）溶解由Cohn IV-1馏分构成的起始糊状物并分级 沉淀; b）疏水相互作用层析; c）病毒灭活; 和d）最后的操作。 FO