利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

189 条记录 (耗时 0.015 秒)

    IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION
    81.
    发明公开
    IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION 有权
    随着嵌入式脂质体植入基质组成，其使用AS POYLCAPROLACTONPARTIKEL代表组织再生

    公开(公告)号：EP2370112A4

    公开(公告)日：2013-04-10

    申请号：EP09828393

    申请日：2009-11-24

    申请人： SCHUBERT HOLDINGS LLC

    发明人： SCHUBERT SHAI YEHOSHUA

    IPC分类号： A61K51/12 ,  A61K38/00 ,  A61K38/39 ,  A61L27/52 ,  A61L27/54

    CPC分类号： A61L27/54 ,  A61K48/0016 ,  A61L27/18 ,  A61L27/222 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/426 ,  A61L2300/438 ,  A61L2300/45 ,  A61L2300/626 ,  A61L2400/06 ,  C08L67/04

    摘要： In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.

    摘要翻译： 在各种实施方案中，本发明描述了用于细胞在位置处的局部重编程，其中处理应用于材料和方法。 本发明可被用来代替丢失的细胞或恢复功能受损组织因疾病，损伤或遗传缺陷。 在各种实施方案中，治疗包括嵌入与脂质体的半固体水凝胶。 脂质体可以包含在效应分子或分子。 当吞噬细胞：如单核细胞渗入的水凝胶，他们遇到的脂质体和合并携带效应分子进入细胞的脂质体。 在一些实施方案中，效应分子可以是编码特定蛋白质的表达的遗传物质：如转录因子，其表达可以启动细胞的重编程。 在其它实施方案中，效应分子可以诱导血管生成。 在其它实施方案中，效应分子是肿瘤抗原。 基质可以包含旨在吸引特定细胞与基质的其它效应分子。 所述细胞可从基质作为基质降解或通过活性迁移从基质释放。 因此，细胞可以保留在基质和秘密分子：如蛋白质和激素通过基质材料向周围组织thatwill扩散。

    IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION
    84.
    发明公开
    IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION 有权
    植物人造脊椎动物麻醉药EIPEBETTETEN LIPOSOMEN，UND IHRE VERWENDUNG

    公开(公告)号：EP2370112A2

    公开(公告)日：2011-10-05

    申请号：EP09828393.0

    申请日：2009-11-24

    申请人： Schubert Holdings LLC

    发明人： SCHUBERT, Shai, Yehoshua

    IPC分类号： A61K51/12 ,  A61L27/54 ,  A61K38/00 ,  A61L27/52 ,  A61K38/39

    CPC分类号： A61L27/54 ,  A61K48/0016 ,  A61L27/18 ,  A61L27/222 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/426 ,  A61L2300/438 ,  A61L2300/45 ,  A61L2300/626 ,  A61L2400/06 ,  C08L67/04

    摘要： In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.

    摘要翻译： 在各种实施方案中，本发明描述了在施用治疗的位置中细胞局部重编程的材料和方法。 本发明可用于替代损失的细胞或恢复由于疾病，损伤或遗传缺陷而损伤的组织的功能。 在各种实施方案中，治疗包括含有脂质体的半固体水凝胶。 脂质体可以含有效应分子或分子。 当吞噬细胞如单核细胞渗入水凝胶时，它们遇到脂质体并将携带效应分子的脂质体并入细胞。 在一些实施方案中，效应分子可以是编码特异性蛋白质表达的遗传物质，例如转录因子，其表达可以启动细胞的重新编程。 在其它实施方案中，效应分子可诱导血管发生。 在其它实施方案中，效应分子是肿瘤抗原。 该基质可包含旨在吸引特定细胞至基质的其他效应分子。 当基质降解或通过从基质的活性迁移时，可以从基质中释放细胞。 细胞也可以保留在基质中，并且可以通过基质材料扩散到周围组织的秘密分子如蛋白质和激素。