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公开(公告)号：EP2832722A4
公开(公告)日：2015-08-12
申请号：EP13767453
申请日：2013-03-29
申请人： TAISHO PHARMA CO LTD
发明人： YOSHINAGA MITSUKANE , ISHIZAKA TOMOKO , WAKASUGI DAISUKE , SHIROKAWA SHIN-ICHI , HATTORI NOBUTAKA , KASHIWA SHUHEI , KUWADA TAKESHI , SHIMAZAKI YOUICHI
IPC分类号： C07D209/10 , A61K31/405 , A61K31/4184 , A61K31/438 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61P1/14 , A61P7/10 , A61P9/10 , A61P9/12 , A61P17/14 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D491/107 , C07D209/10 , C07D231/56 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D471/04 , C07D491/08
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82.发明授权NEUTRALIZING PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) VARIANTS AND USES THEREOF 有权中和前蛋白转化酶枯草杆菌蛋白酶Kexin TYPE 9-（PCSK9-）的变种及其应用
公开(公告)号：EP2296694B1
公开(公告)日：2015-08-05
申请号：EP09735447.6
申请日：2009-02-20
申请人： Amgen Inc.
IPC分类号： A61K38/48 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K45/06 , A61K31/47 , A61K31/505 , C12N9/64
CPC分类号： C12Y304/21061 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K38/00 , A61K38/482 , A61K45/06 , C12N9/6454 , A61K2300/00
摘要： Neutralizing PCSK9 variants that interact with low density lipoprotein receptor (LDLR) are described. Methods and compositions for treating disorders by administering a pharmaceutically effective amount of a neutralizing PCSK9 variant are described.
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公开(公告)号：EP2844241A4
公开(公告)日：2015-04-29
申请号：EP13823428
申请日：2013-06-28
发明人： DILL DAVID A
IPC分类号： A61K31/19 , A61K9/22 , A61K9/24 , A61K9/28 , A61K31/12 , A61K31/167 , A61K31/192 , A61K31/405 , A61K31/437 , A61K31/4985 , A61K31/60 , A61K45/06
CPC分类号： A61K31/167 , A61K9/209 , A61K9/2866 , A61K31/12 , A61K31/192 , A61K31/405 , A61K31/437 , A61K31/4985 , A61K31/60 , A61K31/616 , A61K38/4893 , A61K45/06 , C12Y304/24069 , A61K2300/00
摘要： Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in an extended-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients formulated for extended-release.
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84.发明公开
公开(公告)号：EP2781508A4
公开(公告)日：2015-04-29
申请号：EP12850344
申请日：2012-11-16
IPC分类号： C07D209/22 , A61K31/405 , A61K31/416 , A61K31/4162 , A61P11/06 , A61P37/00 , C07D231/56 , C07D403/06 , C07D471/04
CPC分类号： A61K31/405 , A61K31/416 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K45/06 , C07D209/14 , C07D209/22 , C07D231/56 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D471/04
摘要： The present application relates to nitrogen-containing fused ring compounds shown by general formula (I), a pharmaceutically acceptable salt thereof and a stereoisomer thereof as CRTH2 antagonist, wherein X 1 , X 2 , X 3 , X 4 , X 5 , W, X, Y, L 1 , L 2 , L 3 , A, B are as defined in the description; the present application further relates to a method for preparing the compounds, a pharmaceutical formulation and a pharmaceutical composition comprising the compounds, a use of the compounds for the manufacture of a medicament for the treatment and/or prevention of diseases related to activity of CRTH2.
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85.发明公开Compositions and methods for improving cognitive function 审中-公开Zusammensetzungen und Verfahren zur Verbesserung der kognitiven Funktion
公开(公告)号：EP2859889A1
公开(公告)日：2015-04-15
申请号：EP13382406.0
申请日：2013-10-14
申请人： ABBOTT LABORATORIES
发明人： Barranco Perez, Alejandro , Vazquez Hernandez, Enrique , Ramirez Gonzalez, Maria , Rueda Cabrera, Ricardo
IPC分类号： A61K31/14 , A61K31/191 , A61K31/405 , A61K31/685 , A61K33/06 , A61P25/26 , A61P25/28
CPC分类号： A61K31/191 , A01K1/031 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K9/0053 , A61K31/14 , A61K31/405 , A61K31/685 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： Compositions including a combination of a source of choline, a source of magnesium, and a source of L-tryptophan are provided for improving cognitive performance in a subject. The compositions may improve a cognitive impairment and/or brain dysfunction associated with age-related cognitive decline or cognitive decline resulting from a neurodegenerative disease. The compositions may also be effective in improving memory acquisition, memory retention, and recall.
摘要翻译： 提供包括胆碱来源，镁源和L-色氨酸来源的组合物，用于改善受试者的认知表现。 组合物可以改善与由神经变性疾病引起的与年龄有关的认知衰退或认知衰退相关的认知障碍和/或脑功能障碍。 组合物还可以有效地改善记忆获取，记忆保留和回忆。
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86.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开方法和药物组合物，预防或治疗慢性阻塞性肺疾病
公开(公告)号：EP2846793A1
公开(公告)日：2015-03-18
申请号：EP13721712.1
申请日：2013-05-07
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paris-Est Créteil Val de Marne , Assistance Publique - Hôpitaux de Paris , Agroparistech
IPC分类号： A61K31/352 , A61K31/403 , A61K31/405 , A61K31/415 , G01N33/50 , A61P11/00
CPC分类号： A61K31/415 , A61K31/352 , A61K31/403 , A61K31/4035 , A61K31/405 , G01N33/502 , G01N33/6884 , G01N2500/10 , G01N2800/122
摘要： The present invention relates to methods and compositions for the prevention or treatment of chronic obstructive pulmonary disease.
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公开(公告)号：EP2832722A1
公开(公告)日：2015-02-04
申请号：EP13767453.7
申请日：2013-03-29
发明人： YOSHINAGA, Mitsukane , ISHIZAKA, Tomoko , WAKASUGI, Daisuke , SHIROKAWA, Shin-ichi , HATTORI, Nobutaka , KASHIWA, Shuhei , KUWADA, Takeshi , SHIMAZAKI, Youichi
IPC分类号： C07D209/10 , A61K31/405 , A61K31/4184 , A61K31/438 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61P1/14 , A61P7/10 , A61P9/10 , A61P9/12 , A61P17/14 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D491/107 , C07D209/10 , C07D231/56 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D471/04 , C07D491/08
摘要： The present invention provides agents for treating or preventing diseases such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, alopecia. Specifically, the invention provides fused azole derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof that have an antagonistic action against the arginine-vasopressin 1b receptor:
摘要翻译： 本发明提供用于治疗或预防诸如心境障碍，焦虑症，精神分裂症，阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病，进食障碍，高血压，胃肠疾病，药物成瘾，癫痫，脑梗塞，脑缺血，脑水肿 ，头部损伤，炎症，免疫相关疾病，脱发。 具体而言，本发明提供通式（I）表示的稠合唑衍生物或其可药用盐，其对精氨酸 - 加压素1b受体具有拮抗作用：
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公开(公告)号：EP2717698A4
公开(公告)日：2015-01-07
申请号：EP12796984
申请日：2012-06-08
IPC分类号： A61K31/4402 , A61K31/135 , A61K31/4045 , A61K31/405 , A61K31/4415 , A61K31/495 , A61K31/56 , A61K36/84 , A61K45/06 , A61P25/00 , A61P25/20
CPC分类号： A61K31/4415 , A23L2/52 , A61K31/4045 , A61K31/405 , A61K31/4402 , A61K31/495 , A61K31/56 , A61K36/84 , A61K45/06 , A61K2300/00
摘要： The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans.
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公开(公告)号：EP2311452B9
公开(公告)日：2014-12-24
申请号：EP10006974.9
申请日：2000-01-07
申请人： Yu, Ruey J. , Van Scott, Eugene J.
发明人： Yu, Ruey J. , Van Scott, Eugene J.
IPC分类号： A61K31/401 , A61K31/198 , A61K31/7008 , A61K31/405 , A61K9/06 , A61P17/04 , A61P17/10 , A61P31/10 , A61K8/73 , A61Q19/00 , A61K8/60 , A61K8/44 , A61K8/49 , A61Q3/00 , A61Q5/02 , A61Q19/02 , A61Q19/08 , A61K9/00 , A61K45/06 , A61K31/4045 , A61Q5/00
CPC分类号： A61Q19/08 , A61K8/44 , A61K8/447 , A61K8/4913 , A61K8/60 , A61K9/0014 , A61K9/06 , A61K31/198 , A61K31/401 , A61K31/4045 , A61K31/405 , A61K31/7008 , A61K45/06 , A61Q3/00 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61Q19/02 , Y10S514/844 , Y10S514/847 , A61K2300/00
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90.发明授权COMPOUNDS FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES, IMMUNO-ALLERGICAL DISEASES AND ORGAN OR TISSUE TRANSPLANTATION REJECTION 有权自身免疫性疾病和器官或免疫过敏性疾病的化合物治疗GEWEBETRANSPLANTATABSTOSSUNG
公开(公告)号：EP1546088B1
公开(公告)日：2014-12-17
申请号：EP03758581.7
申请日：2003-10-01
申请人： Novaremed Ltd.
发明人： KAPLAN, Eliahu
IPC分类号： C07C233/11 , C07D233/64 , C07D209/16 , C07C233/22 , C07D209/14 , C07C215/52 , C07D209/18 , C07C235/34 , A61K31/417 , A61K31/4045 , A61K31/405 , A61K31/137 , A61K31/165 , A61K31/765 , A61P37/06
CPC分类号： C07D233/64 , C07C233/11 , C07C233/22 , C07C235/34 , C07D209/14 , C07D209/16 , C07D209/18 , C08G65/3332 , C08G65/33396
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