公开(公告)号：EP2782583A4

公开(公告)日：2016-04-13

申请号：EP12851204

申请日：2012-11-21

申请人： UNIV JOHNS HOPKINS

发明人： TALALAY PAUL ,  USHIDA YUSUKE

IPC分类号： A61K31/56 ,  A61K31/26 ,  A61K31/275 ,  A61P25/32

CPC分类号： A61K31/26 ,  A23L33/10 ,  A61K31/275

摘要： The present invention comprises methods and compositions for reducing ethanol toxicity due to accumulation of acetaldehyde in a cell. A method comprises administering to a cell a composition comprising a compound that increases the expression, the amount of, and/or the activity of at least one member of the aldehyde dehydrogenase superfamily.

摘要翻译： 本发明包括由于乙醛在细胞中蓄积而降低乙醇毒性的方法和组合物。 一种方法包括向细胞施用包含增加醛脱氢酶超家族的至少一种成员的表达，量和/或活性的化合物的组合物。

公开(公告)号：EP2968990A1

公开(公告)日：2016-01-20

申请号：EP14782877.6

申请日：2014-03-15

申请人： NUTRAMAX LABORATORIES, INC.

发明人： CORNBLATT, Brian ,  BZHELYANSKY, Anton ,  HENDERSON, Robert ,  HSU, Chia-Ping Charles

IPC分类号： A61P19/04 ,  A61K31/095 ,  A61K31/26

CPC分类号： A61K38/47 ,  A61K31/275 ,  A61K31/375 ,  A61K31/575 ,  A61K31/7004 ,  A61K31/7028 ,  A61K36/31 ,  A61K38/43 ,  A61K45/06 ,  C12Y302/01147 ,  A61K2300/00

摘要： The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and a phytosterol and/or phytostanol or ester thereof. The invention also relates to the combination of a sulforaphane or a derivative thereof and a phytosterol and/or phytostanol or ester thereof. The invention also relates to the combination of a broccoli extract or powder and a phytosterol and/or phytostanol or ester thereof. The invention provides compositions and methods relating to these combinations.

摘要翻译： 本发明涉及萝卜硫素前体，能够将萝卜硫素前体转化为萝卜硫素的酶，酶增效剂和植物甾醇和/或植物甾烷醇或其酯的组合。 本发明还涉及萝卜硫烷或其衍生物与植物甾醇和/或植物甾烷醇或其酯的组合。 本发明还涉及西兰花提取物或粉末与植物甾醇和/或植物甾烷醇或其酯的组合。 本发明提供了涉及这些组合的组合物和方法。

公开(公告)号：EP2842940A4

公开(公告)日：2015-11-18

申请号：EP13757087

申请日：2013-03-06

申请人： CONSEJO SUPERIOR INVESTIGACION ,  UNIV SEVILLA

发明人： KHIAR EL WAHABI NOUREDDINE ,  FERNÁNDEZ FERNÁNDEZ INMACULADA ,  RECIO JIMÉNEZ ROCÍO

IPC分类号： C07C331/20 ,  A61K31/26

CPC分类号： C07C331/20 ,  A61K31/26 ,  A61K31/795 ,  A61K45/06

摘要： The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.

公开(公告)号：EP2919775A1

公开(公告)日：2015-09-23

申请号：EP13792389.2

申请日：2013-11-19

申请人： Rosengren, Anders ,  Axelsson, Annika

发明人： Rosengren, Anders ,  Axelsson, Annika

IPC分类号： A61K31/26 ,  A61K36/31 ,  A61P3/10

CPC分类号： A61K31/26 ,  A61K36/31

摘要： The present invention provides sulforaphane, or a plant extract comprising sulforaphane, for treating or reducing insulin resistance of the liver. Especially, there is provided sulforaphane, or a plant extract comprising sulforaphane, for treating or reducing insulin resistance of the liver, wherein, in the subject to be treated, the insulin resistance index of the liver is higher than the insulin resistance of other metabolic tissue.

公开(公告)号：EP2773212A4

公开(公告)日：2015-07-01

申请号：EP12844756

申请日：2012-10-31

申请人： UNIV JOHNS HOPKINS

发明人： TALALAY PAUL ,  ZIMMERMAN ANDREW W ,  SMITH KIRBY D

IPC分类号： A61K31/26 ,  A61K31/145 ,  A61K31/167 ,  A61K31/18 ,  A61K31/19 ,  A61K31/343 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/517 ,  A61K31/70 ,  A61P25/00 ,  G01N33/50

CPC分类号： A61K31/17 ,  A61K31/145 ,  A61K31/165 ,  A61K31/167 ,  A61K31/18 ,  A61K31/19 ,  A61K31/192 ,  A61K31/26 ,  A61K31/343 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/517 ,  A61K31/70 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/5044 ,  G01N2500/10 ,  G01N2800/2814 ,  G01N2800/52

摘要： Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder. More particularly, said methods and compositions utilise hydroxyurea.

公开(公告)号：EP2758367A1

公开(公告)日：2014-07-30

申请号：EP12766588.3

申请日：2012-09-18

申请人： 2Lution GmbH

发明人： KALBE, Jochen ,  HANSEN, Olaf

IPC分类号： C07C265/12 ,  C07C331/28 ,  A61K31/26 ,  A61P35/00

CPC分类号： C07D233/64 ,  C07C265/12 ,  C07C309/15 ,  C07C331/28

摘要： The invention relates to novel isocyanate and isothiocyanate compounds, pharmaceutical compositions comprising same, and the use thereof for the treatment of cancer in humans and animals. Compared with previously known isocyanate and isothiocyanate compounds, the novel isocyanate and isothiocyanate compounds are characterized by greater therapeutic breadth, i.e. fewer side effects and high antitumor activity.

公开(公告)号：EP2528607A4

公开(公告)日：2014-07-16

申请号：EP11737764

申请日：2011-01-28

申请人： UNIV JOHNS HOPKINS

发明人： BISWAL SHYAM ,  THIMMULAPPA RAJESH KUMAR

IPC分类号： A61K31/573 ,  A61K31/00 ,  A61K31/26 ,  A61K45/06 ,  A61P11/00 ,  A61P11/06 ,  A61P19/02 ,  A61P37/00

CPC分类号： A61K31/00 ,  A61K31/26 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP2729154A1

公开(公告)日：2014-05-14

申请号：EP12730224.8

申请日：2012-07-03

申请人： Pauletto, Alberto

发明人： Pauletto, Alberto

IPC分类号： A61K33/06 ,  A61K31/26 ,  A61K33/26 ,  A61P17/02

CPC分类号： A61K33/06 ,  A61K31/26 ,  A61K31/717 ,  A61K33/26 ,  A61K2300/00

摘要： A hemostatic agent particularly for use in surgical procedures, comprising, in an aqueous solution, at least: - 5% to 30% by weight of an aluminum salt; - 1% to 30% by weight of an iron salt; - 0.1% to 8% by weight of methylcellulose.

公开(公告)号：EP2725907A1

公开(公告)日：2014-05-07

申请号：EP12804776.8

申请日：2012-06-28

申请人： THE WILLIAM M. YARBROUGH FOUNDATION

发明人： SILVER, Michael, E.

IPC分类号： A01N47/00 ,  A61K31/21 ,  A61K31/26

CPC分类号： A61K31/26 ,  A61K9/0014 ,  A61K31/198 ,  A61K45/06 ,  A61K2300/00

摘要： A method for treating eczema including the steps of applying an isothiocyanate functional surfactant to an area affected by eczema, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

公开(公告)号：EP2416792A4

公开(公告)日：2012-10-24

申请号：EP10762568

申请日：2010-04-12

申请人： QI HAIYAN

发明人： QI HAIYAN

IPC分类号： A61K35/74 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/105 ,  A61K31/122 ,  A61K31/155 ,  A61K31/26 ,  A61K31/352 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/436 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/573 ,  A61K33/06 ,  A61K36/45 ,  A61K36/87 ,  A61K38/22 ,  G01N33/53

CPC分类号： A61K31/436 ,  A61K8/49 ,  A61K31/01 ,  A61K31/015 ,  A61K31/05 ,  A61K31/105 ,  A61K31/122 ,  A61K31/145 ,  A61K31/155 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/4045 ,  A61K31/453 ,  A61K31/4709 ,  A61K31/567 ,  A61K31/573 ,  A61K31/7004 ,  A61K31/7056 ,  A61K33/04 ,  A61K38/063 ,  A61K45/06 ,  A61Q19/08 ,  C12Q1/025 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5044 ,  G01N33/5079 ,  G01N33/6875 ,  G01N33/6893 ,  G01N2333/39 ,  G01N2800/02 ,  Y02A90/26 ,  A61K2300/00

摘要： The present invention discloses mechanisms in the aging process and describes agents to be used for improving mitochondrial function, maintaining the cell cycle- arrested state in senescent and post mitotic cells, and thus preventing or treating age- related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.

摘要翻译： 本发明公开了老化过程中的机制，并描述了用于改善线粒体功能，维持衰老和有丝分裂细胞后的细胞周期阻滞状态的药剂，从而预防或治疗与加速的线粒体功能相关的年龄相关疾病或病症 损失，端粒功能障碍和/或生长停滞状态的恶化。 本发明还公开了许多化合物或组合物。 本发明进一步提供低剂量的雷帕霉素或其类似物作为模拟限制热量以防止与年龄有关的疾病或病症的用途。