摘要:
Disclosed are trans -1,2-cyclohexane bis[urea-urethane] compounds of the formulae
and
wherein R 1 and R' 1 each, independently of the other, is an alkylene group, an arylene group, an arylalkylene group, or an alkylarylene group, R 2 and R' 2 each, independently of the other, is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, R 3 and R' 3 each, independently of the other, is a hydrogen atom or an alkyl group, R 4 and R' 4 each, independently of the other, is a hydrogen atom, a fluorine atom, an alkyl group, or a phenyl group, n is an integer of 0, 1, 2, 3, or 4, and R 5 is an alkyl group, an aryl group, an arylalkyl group, an alkylaryl group, or a substituent other than an alkyl, aryl, arylalkyl, or alkylaryl group.
摘要:
The invention relates to novel compounds of formula (I), wherein R, R1, R2 and R3 have the meaning cited in patent claim 1. Said compounds are inhibitors of coagulation factor Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors.
摘要:
The invention provides compounds of formula I: useful in treating Alzheimer’s disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer’s disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
摘要:
The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises a core which is functionalized with three amino acid derived groups by means of an amide or urea linkage. It may be used to gelate or thicken numerous solvents.
摘要:
Disclosed are novel urea derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The urea derivative according to the present invention has the chemical structure, for example, represented by the following Formula (35):
摘要:
Die Erfindung betrifft Verbindungen der allgemeinen Formel 1 OCN-R 1 -NHCOX-R 2 -(Y) n in der X eine kovalente Bindung zu R 2 darstellt oder O, S oder NR 3 ist, Y ein Wasserstoffatom oder eine freie funktionelle Gruppe bedeutet und n für eine ganze Zahl von 1 bis 20 steht. Ferner betrifft die Erfindung ein Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Funktionalisierung oder Modifizierung von Verbindungen oder festen Oberflächen, die mindestens eine mit Isocyanat reaktive Gruppe aufweisen.
摘要:
There are disclosed novel neuropeptide Y ligands having general formula (I) wherein the symbols W, A, D, R?1, R2, R3, R4¿ are further defined in the description. Compounds of formula (I) are agonists and antagonists of neuropeptide Y, and are therefore useful as regulators of neuropeptide Y activity and in treating disorders related thereto.
摘要:
Process for preparing 1,3-disubstituted urea of the formula: wherein R 5 is the same as or different from R 6 , and each of R 5 and R 6 is independently linear or branched, alkyl of 1-20 carbon atoms, alkenyl group having 2 to 20 carbon atoms or alkynyl group having 2 to 20 carbon atoms, which may have phenoxy, alkoxy of 1-13 carbon atoms, monocycloalkyl of 3-8 carbon atoms, bicycloalkyl of 6-12 carbon atoms, aryl of 6-13 carbon atoms, furyl, pyridyl, or aralkyl of 7-20 carbon atoms, comprising reacting cyclic carbonic acid ester with an amine using alkali metal alkoxide or trialkylamine as base, in safety and high yield.