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1.发明公开INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 有权RAF激酶的抑制使用芳基 - 和杂芳基的杂环脲类
公开(公告)号：EP1056725A4
公开(公告)日：2001-02-07
申请号：EP98963810
申请日：1998-12-22
申请人： BAYER AG
发明人： DUMAS JACQUES , KHIRE UDAY , LOWINGER TIMOTHY BRUNO , PAULSEN HOLGER , RIEDL BERND , SCOTT WILLIAM J , SMITH ROGER A , WOOD JILL E , HATOUM-MOKDAD HOLIA , JOHNSON JEFFREY , REDMAN ANIKO , SIBLEY ROBERT
IPC分类号： C07D231/38 , A61K31/341 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/506 , A61P35/00 , A61P43/00 , C07D231/40 , C07D307/66 , C07D333/36 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/12
CPC分类号： C07D401/12 , C07D231/40 , C07D333/36 , C07D401/14 , C07D405/04
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2.发明公开
公开(公告)号：EP1042305A4
公开(公告)日：2003-05-14
申请号：EP98964221
申请日：1998-12-22
申请人： BAYER AG
发明人： MILLER SCOTT , OSTERHOUT MARTIN , DUMAS JACQUES , KHIRE UDAY , LOWINGER TIMOTHY BRUNO , RIEDL BERND , SCOTT WILLIAM J , SMITH ROGER A , WOOD JILL E , GUNN DAVID , HATOUM-MOKDAD HOLIA , RODRIGUEZ MARELI , SIBLEY ROBERT , WANG MING , TURNER TIFFANY , BRENNAN CATHERINE
IPC分类号： C07D295/18 , A61K31/17 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/4166 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/535 , A61K31/5375 , A61P29/00 , A61P43/00 , C07C205/11 , C07C205/22 , C07C205/37 , C07C205/38 , C07C205/57 , C07C205/58 , C07C275/30 , C07C275/32 , C07C275/34 , C07C275/36 , C07C275/40 , C07C275/42 , C07C309/88 , C07C311/48 , C07C317/42 , C07C323/44 , C07C335/18 , C07D207/26 , C07D207/27 , C07D207/40 , C07D207/404 , C07D209/76 , C07D209/86 , C07D209/88 , C07D213/36 , C07D213/40 , C07D213/53 , C07D213/68 , C07D213/70 , C07D231/08 , C07D233/22 , C07D233/34 , C07D233/70 , C07D263/58 , C07D273/00 , C07D275/00 , C07D277/68 , C07D295/185 , C07D307/20 , C07D333/20 , C07D409/12
CPC分类号： C07D207/27 , A61K31/17 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4436 , A61K31/4439 , A61K31/535 , A61K31/5375 , C07C205/11 , C07C205/22 , C07C205/37 , C07C205/38 , C07C205/57 , C07C205/58 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07C275/42 , C07C309/88 , C07C311/48 , C07C317/42 , C07D207/26 , C07D207/404 , C07D209/76 , C07D209/86 , C07D209/88 , C07D213/40 , C07D213/53 , C07D213/68 , C07D213/70 , C07D231/08 , C07D233/22 , C07D233/70 , C07D263/58 , C07D277/68 , C07D295/185 , C07D307/20 , C07D333/20 , C07D409/12
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
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3.发明公开INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 有权INHIBITING p38激酶活性THROUGH芳基 - 和杂芳基脲类的使用
公开(公告)号：EP1043995A4
公开(公告)日：2003-05-07
申请号：EP98964708
申请日：1998-12-22
申请人： BAYER AG
发明人： DUMAS JACQUES , KHIRE UDAY , LOWINGER TIMOTHY BRUNO , RIEDL BERND , SCOTT WILLIAM J , SMITH ROGER A , WOOD JILL E , HATOUM-MOKDAD HOLIA , JOHNSON JEFFREY , REDMAN ANIKO , SIBLEY ROBERT
IPC分类号： C07D333/36 , A61K31/00 , A61K31/381 , A61K31/415 , A61K31/4427 , A61K31/443 , A61K31/4436 , A61P1/04 , A61P9/02 , A61P11/06 , A61P19/02 , A61P19/10 , A61P29/00 , A61P43/00 , C07D231/40 , C07D333/40 , C07D401/12 , C07D405/04 , C07D405/14 , A61K31/38 , A61K31/44
CPC分类号： A61K31/415 , A61K31/00
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
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公开(公告)号：EP1047418A4
公开(公告)日：2001-02-07
申请号：EP98965981
申请日：1998-12-22
申请人： BAYER AG
发明人： DUMAS JACQUES , KHIRE UDAY , LOWINGER TIMOTHY BRUNO , PAULSEN HOLGER , RIEDL BERND , SCOTT WILLIAM J , SMITH ROGER A , WOOD JILL E , HATOUM-MOKDAD HOLIA , JOHNSON JEFFREY , LEE WENDY , REDMAN ANIKO , SIBLEY ROBERT , RENICK JOEL
IPC分类号： A61K31/17 , A61K31/34 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/428 , A61K31/4427 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P43/00 , C07C275/26 , C07C275/28 , C07D231/40 , C07D257/06 , C07D261/14 , C07D271/10 , C07D271/113 , C07D277/28 , C07D285/12 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D521/00 , A61K31/44 , A61K31/47 , C07D215/20
CPC分类号： C07D271/113 , C07D231/12 , C07D231/40 , C07D233/56 , C07D249/08 , C07D257/06 , C07D261/14 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
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