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    METHODS FOR IMPROVING ANALYTE DETECTION USING PHOTOCHEMICAL REACTIONS
    81.
    发明公开
    METHODS FOR IMPROVING ANALYTE DETECTION USING PHOTOCHEMICAL REACTIONS 审中-公开
    VERFAHRENFÜRVERBESSERTEN ANALYTNACHWEIS MITTELS PHOTOCHEMISCHER REAKTIONEN

    公开(公告)号：EP3066471A4

    公开(公告)日：2017-05-10

    申请号：EP14859021

    申请日：2014-11-02

    申请人： ALLIED INNOVATIVE SYSTEMS LLC

    发明人： BYSTRYAK SIMON ,  SANTOCKYTE RASA

    IPC分类号： G01N33/533 ,  G01N21/75 ,  G01N33/535 ,  G01N33/544

    CPC分类号： G01N33/533 ,  C12Q1/28 ,  C12Q1/682 ,  C12Q1/703 ,  C12Q2600/158 ,  G01N33/5306 ,  G01N33/542 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/56994

    摘要： An improved assay for detecting an analyte in a fluid sample includes a step of conducting a photochemical reaction, in which a substrate conversion catalyzed by a photosensitizer into a product of the photochemical reaction is temporary inhibited when the reaction mixture is irradiated with a light at a wavelength within a light absorption spectrum of the photosensitizer. The photosensitizer (or an enzyme to catalyze producing thereof) is attached to an entity having an affinity to the analyte, such entity is bound to the analyte prior to irradiation. To achieve temporary inhibition, certain additives are used such as ascorbic acid or its derivatives. The assay may increase the sensitivity of ELISA 20- to 100-fold.

    摘要翻译： 用于检测流体样品中的分析物的改进的测定法包括进行光化学反应的步骤，其中当用光照射反应混合物时，由光敏剂催化的底物转化成光化学反应的产物被暂时抑制 波长在光敏剂的光吸收光谱内。 光敏剂（或催化其产生的酶）附着到对分析物具有亲和力的实体上，这种实体在照射之前与分析物结合。 为了达到暂时抑制，使用某些添加剂如抗坏血酸或其衍生物。 该测定可以将ELISA的灵敏度提高20到100倍。

    AFLATOXIN NANOBODY IMMUNOABSORBENT AND IMMUNOAFFINITY COLUMN AND PREPARATION METHOD AND USE THEREOF
    82.
    发明公开
    AFLATOXIN NANOBODY IMMUNOABSORBENT AND IMMUNOAFFINITY COLUMN AND PREPARATION METHOD AND USE THEREOF 审中-公开
    黄曲霉毒素NANO体免疫吸附和免疫亲和柱及生产方法和用途

    公开(公告)号：EP3124973A1

    公开(公告)日：2017-02-01

    申请号：EP14887513.1

    申请日：2014-08-27

    申请人： Oilcrops Research Institute of Chinese Academy of Agriculture Sciences

    发明人： LI, Peiwu ,  ZHANG, Qi ,  WANG, Yanru ,  ZHANG, Zhaowei ,  DING, Xiaoxia

    IPC分类号： G01N33/569 ,  G01N33/544 ,  G01N33/531

    CPC分类号： C07K16/14 ,  C07K1/22 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/56961 ,  G01N2333/38

    摘要： An aflatoxin nanobody immunoabsorbent and immunoaffinity column and preparation method and use thereof. The immunoabsorbent comprises a solid phase carrier and aflatoxin B1 nanobody 2014AFB-G15 coupled with the solid phase carrier. The 50% inhibiting concentration IC 50 of aflatoxin B1 nanobody 2014AFB-G15 to aflatoxin B1 is 0.66 ng/mL, and the cross-reactivity of aflatoxin B1 nanobody 2014AFB-G15 to aflatoxins B2, G1, G2, and M1 are respectively 22.6%, 10.95%, 32.1% and 26%. The amino acid sequence of aflatoxin B1 nanobody 2014AFB-G15 is as depicted by SEQ ID NO: 7, and the coding gene sequence thereof is as depicted by SEQ ID NO: 8. The aflatoxin nanobody immunoaffinity column can be used for purification and concentration of sample extract prior to computer testing, and the immunoaffinity column can be reused repeatedly.

    摘要翻译： 黄曲霉毒素纳米体免疫吸附和免疫亲和柱和制备方法及其用途。 在免疫吸附包括固相载体和黄曲霉毒素B1的纳米体2014AFB-G15加上固相载体。 50％抑制浓度的黄曲霉毒素B1的纳米体2014AFB-G15的IC 50至黄曲霉毒素B1为0.66毫微克/毫升，和黄曲霉毒素B1的纳米体2014AFB-G15的交叉反应黄曲霉毒素B2，G1，G2和M1分别为22.6％ 10.95％，32.1％和26％。 黄曲霉毒素B1的纳米体2014AFB-G15的氨基酸序列如所描绘的SEQ ID NO：7，以及它们的如SEQ ID NO所示的编码基因序列：8.黄曲霉毒素纳米体免疫亲和柱可用于纯化和浓度 前计算机测试样品提取物和免疫亲和柱可反复再使用。

    Magnetic recognition system
    85.
    发明公开
    Magnetic recognition system 审中-公开
    磁铁Erkennungssystem

    公开(公告)号：EP2428799A1

    公开(公告)日：2012-03-14

    申请号：EP11182249.0

    申请日：2007-11-02

    申请人： ITI Scotland Limited

    发明人： Dehal, Prabhjyot ,  Pritchard, David ,  Geekie, Claire

    IPC分类号： G01N33/543 ,  G01N33/58 ,  G01N33/544

    CPC分类号： G01N33/5434 ,  G01N2446/80

    摘要： Provided is a label for an analyte, which label is attached to a magnetic or magnetisable substance, the label comprising:
    (a) a recognition moiety for attaching the label to the analyte; and
    (b) a moiety for binding or encapsulating the magnetic or magnetisable substance;

    wherein the moiety for binding or encapsulating the magnetic or magnetisable substance comprises a metal-binding protein, polypeptide, or peptide.

    摘要翻译： 提供了用于分析物的标签，其标签附着于磁性或可磁化物质，标签包括：（a）用于将标签附着到分析物的识别部分; 和（b）用于结合或包封磁性或可磁化物质的部分; 其中用于结合或包封磁性或可磁化物质的部分包含金属结合蛋白，多肽或肽。

    MAGNETIC RECOGNITION SYSTEM
    88.
    发明公开
    MAGNETIC RECOGNITION SYSTEM 有权
    磁性检测系统

    公开(公告)号：EP2089714A1

    公开(公告)日：2009-08-19

    申请号：EP07824427.4

    申请日：2007-11-02

    申请人： ITI Scotland Limited

    发明人： DEHAL, Prabhjyot ,  PRITCHARD, David ,  GEEKIE, Claire

    IPC分类号： G01N33/544 ,  G01N33/58

    CPC分类号： G01N33/5434 ,  G01N2446/80

    摘要： Provided is a label for an analyte, which label is attached to a magnetic or magnetisable substance, the label comprising: (a) a recognition moiety for attaching the label to the analyte; and (b) a moiety for binding or encapsulating the magnetic or magnetisable substance; wherein the moiety for binding or encapsulating the magnetic or magnetisable substance comprises a metal-binding protein, polypeptide, or peptide.

    LUNG CANCER BIOMARKERS
    90.
    发明公开
    LUNG CANCER BIOMARKERS 审中-公开
    肺癌生物标记

    公开(公告)号：EP1735620A4

    公开(公告)日：2008-04-09

    申请号：EP05731474

    申请日：2005-03-30

    申请人： EASTERN VIRGINIA MED SCHOOL

    发明人： SEMMES OLIVER JOHN ,  CAZARES LISA H ,  ROM WILLIAM

    IPC分类号： G01N33/544 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68

    CPC分类号： G01N33/6851 ,  G01N33/57423 ,  G01N2800/52

    摘要： Disclosed are protein biomarkers and their use in diagnosing lung cancer or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of lung cancer that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of lung cancer. In certain aspects of the invention, the methods include use of a decision tree analysis. Various computer readable media and their use according to the invention are also disclosed.