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公开(公告)号：EP2388276A3
公开(公告)日：2013-11-27
申请号：EP11004890.7
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10 , C07K16/18
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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2.发明授权
公开(公告)号：EP1633785B1
公开(公告)日：2012-11-28
申请号：EP04809410.6
申请日：2004-05-21
申请人： Medarex, Inc.
CPC分类号： C07K16/1278 , A61K47/6835 , A61K51/1009 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
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3.发明公开ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF 有权抗增殖化合物，其结合物，方法，以及它们的用途
公开(公告)号：EP2461830A1
公开(公告)日：2012-06-13
申请号：EP10739817.4
申请日：2010-08-02
申请人： Medarex, Inc.
发明人： CHENG, Heng , CONG, Qiang , GANGWAR, Sanjeev , ZHANG, Qian
CPC分类号： C07K7/06 , A61K38/06 , A61K47/6811 , A61K47/6829 , C07C229/14 , C07C229/16 , C07K5/021 , C07K5/06139 , C07K5/10 , C07K16/18
摘要： Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
摘要翻译： 具有由式（II）表示的结构，其中n，R1，R2，R3，R4和R5中所定义的，可用于治疗肿瘤，可选地，当缀合至检查，以抗体的配体的抗增殖的化合物：
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公开(公告)号：EP1851250B1
公开(公告)日：2012-06-06
申请号：EP06735489.4
申请日：2006-02-17
申请人： Medarex, Inc.
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/21
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.
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5.发明公开
公开(公告)号：EP2129787A4
公开(公告)日：2012-05-02
申请号：EP08744470
申请日：2008-03-27
申请人： MEDAREX INC
CPC分类号： C12N5/0682 , C12N9/003 , C12N15/85 , C12N2840/10 , C12P21/02
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公开(公告)号：EP1572946B1
公开(公告)日：2012-03-14
申请号：EP03752058.2
申请日：2003-09-05
申请人： Amgen, Inc. , Medarex, Inc.
发明人： VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , HUANG, Haichun , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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7.发明公开Humanized antibodies to interferon alpha receptor-1 (IFNAR-1) 审中-公开HumanisierteAntikörpergegen干扰素-α-受体激动剂-1（IFNAR-1）
公开(公告)号：EP2404615A1
公开(公告)日：2012-01-11
申请号：EP10011473.5
申请日：2004-04-23
申请人： Medarex, Inc.
发明人： Cardarelli, Josephine M. , Chen, Tseng-hui, Timothy , King, David , Bebbinbton, Christopher R. , Pogue, Sarah Lee , Carr, Francis J. , Williams, Stephen
IPC分类号： A61K39/395 , C07K16/24 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.
摘要翻译： 公开了结合IFNAR-1的人源化单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人源化抗体和使用人源化抗体的治疗和诊断方法的药物组合物。
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公开(公告)号：EP2388277A2
公开(公告)日：2011-11-23
申请号：EP11004891.5
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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9.发明公开TRANSGENIC ANIMALS EXPRESSING CHIMERIC ANTIBODIES FOR USE IN PREPARING HUMAN ANTIBODIES 无效嵌合抗体表达转基因动物为人类抗体的制备
公开(公告)号：EP2003960A4
公开(公告)日：2009-10-21
申请号：EP07754714
申请日：2007-03-30
申请人： MEDAREX INC
发明人： TANAMACHI DAWN M , BRAMS PETER , BLACK AMELIA
IPC分类号： A01K67/00 , A01K67/027 , A61K39/00 , C12P21/08
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1282 , C07K16/24 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/8509
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公开(公告)号：EP2097534A2
公开(公告)日：2009-09-09
申请号：EP07871698.2
申请日：2007-12-13
申请人： MEDAREX, INC.
发明人： COCCIA, Marco A. , TERRETT, Jonathon A. , KING, David John , PAN, Chin , CARDARELLI, Josephine , YAMANAKA, Mark , HENNING, Karla Ann
IPC分类号： C12P21/08
CPC分类号： C07K16/2875 , A61K47/65 , A61K47/6809 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD70 with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human CD70. In certain embodiments, the antibodies are capable of being internalized into CD70-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD70, as well as methods for treating cancers, such as renal cancer and lymphomas, using an anti-CD7Q antibody of this disclosure.
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