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1.发明授权INTERLEUKIN-4 PROTEIN HAVING BCGF AND TCGF ACTIVITY ON HUMAN CELLS (HUMAN INTERLEUKIN-4) 失效白细胞介素-4蛋白MIT BCGF AND TCGF活性AGAINST人细胞（人白细胞介素4）
公开(公告)号：EP0249613B1
公开(公告)日：1996-07-03
申请号：EP86907184.5
申请日：1986-11-19
发明人： LEE, Frank , YOKOTA, Takashi , ARAI, Ken-ichi , MOSMANN, Timothy , RENNICK, Donna , SMITH, Craig
CPC分类号： C07K16/247 , A61K38/00 , C07K14/5406 , C07K2319/02 , C12N15/66 , C12N15/70 , C12N15/86 , C12N2710/16243
摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
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2.发明公开Antibodies to mammalian interleukin-4 and peptides useful as antigens in their production 失效抗体对哺乳动物白细胞介素-4和用作抗原用于生产它们的肽。
公开(公告)号：EP0675136A3
公开(公告)日：1996-03-13
申请号：EP95108150.4
申请日：1986-11-19
发明人： Lee, Frank , Yokota, Takashi , Arai, Ken-ichi , Mosmann, Timothy , Rennick, Donna , Smith, Craig
IPC分类号： C07K16/24 , C07K14/54 , A61K39/395 , G01N33/68
CPC分类号： C07K16/247 , A61K38/00 , C07K14/5406 , C07K2319/02 , C12N15/66 , C12N15/70 , C12N15/86 , C12N2710/16243
摘要： Antibodies to mammalian Interleukin-4 and muteins are provided, especially to native human IL-4s, as well as peptides useful as antigens in their production. Nucleic acids are disclosed which are capable of coding for the mammalian IL-4s and their muteins.
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3.发明公开Antibodies to mammalian interleukin-4 and peptides useful as antigens in their production 失效Antikörpergegen Saugetier-Interleukin-4和肽verwendbar als Antigenenfürderen Herstellung。
公开(公告)号：EP0675136A2
公开(公告)日：1995-10-04
申请号：EP95108150.4
申请日：1986-11-19
发明人： Lee, Frank , Yokota, Takashi , Arai, Ken-ichi , Mosmann, Timothy , Rennick, Donna , Smith, Craig
IPC分类号： C07K16/24 , C07K14/54 , A61K39/395 , G01N33/68
CPC分类号： C07K16/247 , A61K38/00 , C07K14/5406 , C07K2319/02 , C12N15/66 , C12N15/70 , C12N15/86 , C12N2710/16243
摘要： Antibodies to mammalian Interleukin-4 and muteins are provided, especially to native human IL-4s, as well as peptides useful as antigens in their production. Nucleic acids are disclosed which are capable of coding for the mammalian IL-4s and their muteins.
摘要翻译： 提供哺乳动物白细胞介素-4和突变蛋白的抗体，特别是天然人IL-4，以及在其生产中可用作抗原的肽。 公开了能够编码哺乳动物IL-4及其突变蛋白的核酸。
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公开(公告)号：EP0329363B1
公开(公告)日：1993-03-31
申请号：EP89301341.7
申请日：1989-02-13
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5.发明公开MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-4 AND HYBRIDOMAS PRODUCING THE SAME 失效反对人白细胞介素4单克隆抗体和你GENERATING HYBRID预兆。
公开(公告)号：EP0375743A1
公开(公告)日：1990-07-04
申请号：EP88910302.0
申请日：1988-10-21
CPC分类号： C12N15/66 , A61K38/00 , C07K14/5406 , C07K16/247 , C07K2319/02 , C12N15/70
摘要： Les anticorps monoclonaux de la présente invention sont spécifiques contre l'interleukine-4 humaine. Des kits et des procédés sont également décrits pour détecter, mesurer et immunopurifier l'interleukine-4 humaine, et pour bloquer l'activité biologique de l'interleukine-4 humaine.
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公开(公告)号：EP0355093A1
公开(公告)日：1990-02-28
申请号：EP88902307.0
申请日：1988-02-18
发明人： OTSUKA, Takeshi
CPC分类号： C07K14/5403 , A61K38/00
摘要： De nouvelles protéines interleucine-3 humaines contiennent une substitution non traditionnelle d'acides aminés (Ser --> Pro en position 7) par rapport à des séquences antérieurement décrites d'IL-3 humaine. Des procédés de synthèse de protéines mutantes à conformation et antigénicité neutres sont également décrits. Cette protéine IL-3 humaine favorise la croissance et le développement d'un vaste spectre de lignées hématopoïétiques et peut être utile pour traiter des états caractérisés par une régénération réduite de cellules sanguines et/ou des populations cellulaires, tels que l'hypoplasie de la moelle, des infections chroniques et des thérapies utilisant des transplants de moelle osseuse. La séquence de l'IL-3 décrite est illustrée dans la Figure (I).
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7.发明公开Monoclonal antibodies to immunogenic human interleukin-3 peptide 失效MonoklonaleAntikörpergegen immunogen menschliche Interleukin-3-Peptide。
公开(公告)号：EP0351944A1
公开(公告)日：1990-01-24
申请号：EP89305174.8
申请日：1989-05-23
CPC分类号： C07K14/5403 , C07K16/244
摘要： An immunogenic human interleukin-3 (IL-3) peptide is provided from which monoclonal peptide antibodies can be produced. The peptide of the invention corresponds to an interior subsequence of the IL-3 protein. The invention also includes conjugates of the immunogenic peptide and carriers, and monoclonal antibodies specific for the immunogenic peptide.
摘要翻译： 提供免疫原性人白细胞介素-3（IL-3）肽，从其可以产生单克隆肽抗体。 本发明的肽对应于IL-3蛋白的内部亚序列。 本发明还包括免疫原性肽和载体的缀合物，以及针对免疫原性肽特异性的单克隆抗体。
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公开(公告)号：EP0329363A1
公开(公告)日：1989-08-23
申请号：EP89301341.7
申请日：1989-02-13
摘要： A polypeptide designated H400 and its encoding nucleic acid are provided as markers specific for activated human T cells. Activated T cells are detected immunochemically by monoclonal antibodies specific for H400 or for its immunogenic peptide fragments. Activated T cells are also detected by nucleic acid probes directed to messenger RNA encoding the H400 protein.
摘要翻译： 提供称为H400的多肽及其编码核酸作为对活化的人T细胞特异的标志物。 通过对H400特异性的单克隆抗体或其免疫原性肽片段免疫化学检测活化的T细胞。 活化的T细胞也通过针对编码H400蛋白的信使RNA的核酸探针来检测。
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9.发明公开
公开(公告)号：EP0299782A3
公开(公告)日：1989-08-09
申请号：EP88306486.7
申请日：1988-07-15
CPC分类号： C07K14/535 , A61K38/00
摘要： Human granulocyte-macrophage colony stimulating factor (GM-CSF) polypeptides are provided, as well as methods for synthesizing conformationally and antigenically neutral muteins. The disclosed GM-CSFs promote growth and development of various hematopoietic lineages, and may be useful in treating conditions involving depressed blood cell populations and/or depressed blood cell regeneration, such as myeloid hypoplasia, chronic infections, and hematopoiesis after bone marrow transplantation. The invention also includes a novel mammalian expression vector.
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10.发明公开Monoclonal antibodies against human interleukin-4 and hybridomas producing the same 失效人类白细胞介素-4的单克隆抗体及其生产的杂交瘤
公开(公告)号：EP0314402A3
公开(公告)日：1989-06-07
申请号：EP88309926.9
申请日：1988-10-21
CPC分类号： C12N15/66 , A61K38/00 , C07K14/5406 , C07K16/247 , C07K2319/02 , C12N15/70
摘要： Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.
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