公开(公告)号：EP3183002B1

公开(公告)日：2021-03-03

申请号：EP15834606.4

申请日：2015-08-21

发明人： ZURAWSKI, Daniel V.

IPC分类号： A61K39/395 ,  G01N33/554 ,  C12N1/20 ,  C12N15/00 ,  C07K16/12 ,  G01N33/569 ,  A61K39/00

公开(公告)号：EP2739300B1

公开(公告)日：2019-06-19

申请号：EP12807743.5

申请日：2012-07-05

申请人： Duke University ,  Children's Medical Center Corporation ,  The Government of The US, as Represented by The Secretary of the Army, on behalf of Walter Reed Army Institute of Research

发明人： KIM, Jerome ,  HARRISON, Stephen ,  HAYNES, Barton, F. ,  TOMARAS, Georgia, D. ,  MICHAEL, Nelson

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K39/245 ,  A61K48/00 ,  A61P37/00 ,  A61P31/00 ,  A61K39/21 ,  C07K14/005

公开(公告)号：EP3183002A2

公开(公告)日：2017-06-28

申请号：EP15834606.4

申请日：2015-08-21

申请人： Walter Reed Army Institute of Research ,  Zurawski, Daniel V.

发明人： ZURAWSKI, Daniel V.

IPC分类号： A61K39/395 ,  G01N33/554 ,  C12N1/20 ,  C12N15/00

CPC分类号： C07K16/1203 ,  A61K2039/505 ,  C07K16/1217 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/70 ,  C12N1/20 ,  G01N33/56911 ,  G01N2333/212

摘要： Described are a therapeutic monoclonal antibody specific for the Type Six Secretion System (T6SS) needle protein of Acinetobacter baumannii (A. baumannii) and methods of use. Specifically, the antibody specifically binds to hemolysin co-regulated protein (Hep). Further disclosed are methods of using an anti-Hep antibody for detecting A. baumannii in a sample as well as a mutant A. baumannii strain comprising a deletion or mutation in its genome such that said deletion or mutation interrupts the proper translation of its hep protein.

摘要翻译： 在本申请中描述了对鲍氏不动杆菌的T6SS针状蛋白特异的治疗性单克隆抗体和使用方法。

公开(公告)号：EP1569674B1

公开(公告)日：2014-12-24

申请号：EP03768878.5

申请日：2003-11-12

申请人： Walter Reed Army Institute of Research

发明人： LANAR, David, E. ,  HILLIER, Collette, J. ,  LYON, Jeffrey, A. ,  ANGOV, Evelina ,  KUMAR, Sanjai ,  ROGERS, William c/o Dept. of State ,  BARBOSA, Arnoldo

IPC分类号： C12N15/67 ,  C12N15/10 ,  C12N15/30 ,  C12N1/21 ,  G06F17/30 ,  G06F19/00 ,  A61K39/015 ,  A61P33/06

CPC分类号： A61K39/015 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K14/445 ,  C07K16/205 ,  C12N15/67 ,  C12P21/02 ,  G01N33/56905 ,  G01N2333/445 ,  Y02A50/412 ,  Y02A90/26

摘要： In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) LSA-NRC polypeptide. The method of the present invention produces a highly purified polypeptide which is useful as a vaccine and as a diagnostic reagent.

公开(公告)号：EP2505212A3

公开(公告)日：2013-01-23

申请号：EP12158677.0

申请日：2007-08-29

申请人： The United States of America as Represented By the Secretary of the Army, Walter Reed Army Institute of Research ,  Kincaid, Randall L.

发明人： Kincaid, Randall L. ,  Angov, Evelina ,  Lyon, Jeffrey A.

IPC分类号： A61K48/00

CPC分类号： C07K14/445

摘要： The present invention is directed to recombinant DNA technology and immunology, particularly antigens and related vaccines for prevention of malarial infection. The present invention includes novel recombinant malarial proteins, and fragments of the same, that have unique structural and/or chemical properties that allow them to be expressed in greater quantity in heterologous systems. These recombinant proteins and fragments have immunogenic properties superior to malarial proteins expressed using different expression systems and coding sequences, but having the same primary amino acid sequence.

公开(公告)号：EP1604685B1

公开(公告)日：2012-02-22

申请号：EP05014317.1

申请日：1998-08-25

申请人： CJ Cheiljedang Corporation ,  Walter Reed Army Institute of Research

发明人： Kim, Hyun, Su ,  Yoo, Wang, Don ,  Kim, Soo, Ok ,  Lee, Sung, hee ,  Moon, Sang, Bum ,  Hong, Sun, Pyo ,  Shin, Yong, Cheol ,  Chung, Yong, Ju ,  Eckels, Kenneth, H. Walter Reed Army ,  Innis, Bruce Walter Reed Army ,  Putnak, Joseph, R. Walter Reed Army ,  Binn, Leonard, N. Walter Reed Army ,  Dubois, Doria, R. Walter Reed Army ,  Srivastava, Ashok, I. Walter Reed Army

IPC分类号： A61K39/12 ,  C07K14/18

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24151 ,  Y02A50/39

摘要： A vaccine comprises Japanese encephalitis virus and aluminium hydroxide as adjuvant.

公开(公告)号：EP2139514A1

公开(公告)日：2010-01-06

申请号：EP07754057.3

申请日：2007-03-27

申请人： The United States of America, as represented by the Secretary of the Army, Walter Reed Army Institute of Research

发明人： OAKS, Edwin V. ,  TURBYFILL, Kevin R. ,  KAMINSKI, Robert W.

IPC分类号： A61K39/02 ,  A61P31/04 ,  A61K39/112 ,  A61K39/108

CPC分类号： A61K39/0283 ,  A61K39/39 ,  A61K47/646 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55572 ,  A61K2039/64 ,  Y02A50/474 ,  Y02A50/476 ,  Y02A50/482

摘要： An artificial invasin complex is prepared from purified or recombinantly prepared invasins and gram negative bacteria lipopolysaccharides. Typically, IpaB is mixed with IpaC to form a IpaB:IpaC complex. This invasin protein complex is then mixed with the lipopolysaccharide to form an artificial invasin complex. Additional bioactive molecules can be incorporated into the complex during manufacture. This artificial invasin complex is similar in function to native Invaplex 24 or Invaplex 50. The artificial invasin complex has superior immunogenicity properties relative to the native complex and can be taylor made. Its method of preparation lends itself to scale up. The artificial invasin complex can facilitate transport of biomolecules, therapeutics and antibiotics across cell membranes in a manner similar to native Shigella Invaplex.

摘要翻译： 从纯化或重组制备的侵染素和革兰氏阴性细菌脂多糖制备人造侵染素复合物。 通常，IpaB与IpaC混合形成IpaB：IpaC复合体。 然后将这种侵入蛋白复合物与脂多糖混合形成人造侵袭素复合物。 额外的生物活性分子可以在制造期间结合到复合物中。 这种人造侵染素复合物在功能上与天然Invaplex 24或Invaplex 50类似。人造侵染素复合物相对于天然复合物具有优异的免疫原性，并且可以是泰勒制造的。 其制备方法有助于扩大规模。 人造侵染素复合物可以促进生物分子，治疗剂和抗生素以类似于天然志贺氏菌Invaplex的方式跨细胞膜转运。

公开(公告)号：EP1802336A1

公开(公告)日：2007-07-04

申请号：EP05808091.2

申请日：2005-10-13

申请人： Crucell Holland B.V. ,  GlaxoSmithKline Biologicals SA ,  The Government of the United States, as represen- ted by the Secretary of the Army, on behalf of the Walter Reed Army Institute of Research

发明人： PAU, Maria Grazia ,  GOUDSMIT, Jaap ,  COHEN, Joseph D., GlaxoSmithKline ,  DUBOIS, Patrice M., GlaxoSmithKline ,  STEWART, V. Ann ,  HEPPNER, Donald

IPC分类号： A61K39/015

CPC分类号： A61K39/015 ,  A61K2039/5256 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/6075 ,  Y02A50/412

摘要： Described are vaccine regimens in which specific prime/boost regimens are applied using low-neutralized recombinant adenoviral vectors harboring nucleic acids encoding antigens from Plasmodium falciparum and purified recombinant protein vaccines such as RTS,S, in the context of appropriate adjuvants.

公开(公告)号：EP1143986B1

公开(公告)日：2006-08-02

申请号：EP99960165.1

申请日：1999-10-26

申请人： Walter Reed Army Institute of Research

发明人： OKUNJI, Christopher, O. ,  IWU, Maurice, M. ,  JACKSON, Joan, E. ,  TALLY, John, D., Jr. ,  BACCHI, Cyrus ,  AYAFOR, Johnson, F.

IPC分类号： A61K36/00 ,  A61K36/28 ,  A61K36/906 ,  C07C47/225 ,  C07D311/32 ,  A61P31/10 ,  A61P33/02 ,  C07D303/40

CPC分类号： C07D311/32 ,  A61K36/28 ,  A61K36/88 ,  A61K36/906 ,  C07C47/225 ,  C07D303/40 ,  Y02A50/409 ,  Y02A50/411

摘要： Provided are biologically active extracts from Aframomum aulocacarpus, Aframomun danellii, Dracaena arborea, Eupatorium odoratum, Glossocalyx brevipes and Napoleonaea imperialis which are suitable for use in treating fungal and protozoa diseases.

公开(公告)号：EP1604685A3

公开(公告)日：2006-07-05

申请号：EP05014317.1

申请日：1998-08-25

申请人： Cheil Jedang Corporation ,  Walter Reed Army Institute of Research

发明人： Kim, Hyun, Su ,  Yoo, Wang, Don ,  Kim, Soo, Ok ,  Lee, Sung, hee ,  Moon, Sang, Bum ,  Hong, Sun, Pyo ,  Shin, Yong, Cheol ,  Chung, Yong, Ju ,  Eckels, Kenneth, H. Walter Reed Army ,  Innis, Bruce Walter Reed Army ,  Putnak, Joseph, R. Walter Reed Army ,  Binn, Leonard, N. Walter Reed Army ,  Dubois, Doria, R. Walter Reed Army ,  Srivastava, Ashok, I. Walter Reed Army

IPC分类号： A61K39/12 ,  C07K14/18

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24151 ,  Y02A50/39

摘要： A vaccine comprises Japanese encephalitis virus and aluminium hydroxide as adjuvant.

摘要翻译： 疫苗包括日本脑炎病毒和氢氧化铝作为佐剂。