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公开(公告)号：EP0760798A1
公开(公告)日：1997-03-12
申请号：EP95920433.0
申请日：1995-05-16
申请人： PPG INDUSTRIES, INC.
CPC分类号： B65H54/2836 , B65H54/2893 , B65H57/003 , B65H57/28 , B65H2701/312 , B65H2701/3122 , B65H2701/38 , Y10S242/92
摘要： The present invention relates to methods and apparatus for winding a plurality of strands (20) into a multilayered package (54). The preferred method includes: a) supplying a plurality of strands (20); b) aligning each of the strands in generally adjacent and coplanar alignment (16); c) oscillating the strands about a pivot axis while maintaining the strands in alignment (22); d) reciprocating a reciprocating device generally parallel to a central axis of rotation of a rotatable packaging collector (54); and e) winding the strands about an arcuate surface (57) of the collector to form a multilayered package, such that within each layer of strands wound upon the surface of the rotatable packaging collector (54), each of the plurality of strands is adjacent to each other and essentially free of overlap. The preferred apparatus includes a strand supply device (12); an alignment device (18); a strand oscillating device (22) including a strand guide (24) adapted to oscillate about a pivot axis and having a first arm and a second arm spaced apart to receive and align the strands; a winding device including a rotatable packaging collector (54) having an arcuate surface (57) adapted to receive the strands to form a multilayered package; and a reciprocating device, such that within each layer of strands wound upon the surface of the rotatable packaging collector (54), each of the plurality of strands is adjacent to each other and essentially free of overlap.
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公开(公告)号：EP0710367A1
公开(公告)日：1996-05-08
申请号：EP94921297.0
申请日：1994-06-13
申请人： PPG INDUSTRIES, INC.
发明人： VAN GEMERT, Barry , KUMAR, Anil
IPC分类号： G02C7 , C07D311 , C07D405 , C07D407 , C07D409 , C08K5 , C08L25 , C08L33 , C08L67 , C08L75 , C08L101 , C09K9 , C09K11 , G02B1 , G02B5
CPC分类号： G02B5/23 , C07D311/92
摘要： Described are novel reversible photochromic 3H-naphtho-[2,1-b]pyran compounds, of graphic formula (IA), wherein R1 is hydrogen or alkyl, R2 is hydrogen or preferably a carboalkoxy group and R3 is hydrogen or preferably an alkyl group, provided that either R1 or R2 is hydrogen, and B and B' are the aryl groups phenyl or naphthyl, a heterocyclic aromatic group or together form a spiro adamantylene group. Also described are organic host materials that contain or that are coated with such compounds. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., spiro(oxazine) type compounds, are also described.
摘要翻译： 描述了式（IA）的新型可逆性光致变色3H-萘并[2,1-b]吡喃化合物，其中R 1为氢或烷基，R 2为氢或优选烷氧羰基，R 3为氢或优选烷基 条件是R1或R2是氢，B和B'是芳基苯基或萘基，杂环芳基或一起形成螺金刚烷基。 还描述了含有或被这种化合物涂覆的有机主体材料。 还描述了诸如眼科镜片或其他塑料透明片，其将新型萘并吡喃化合物或其组合与互补光致变色化合物例如螺（恶嗪）类化合物结合。
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公开(公告)号：EP0704067A1
公开(公告)日：1996-04-03
申请号：EP94920739.0
申请日：1994-06-13
申请人： PPG INDUSTRIES, INC.
发明人： KNOWLES, David, B.
CPC分类号： C07D405/04 , C07D407/04 , C08K5/0041 , C08K5/1545 , G02B5/23
摘要： Described are novel reversible photochromic naphthopyran compounds, examples of which are compounds substituted at the 3 position of the pyran ring with (i) an aryl substituent and (ii) a phenyl substituent having a 5- or 6-member heterocyclic ring fused at the number 3 and 4 carbon atoms of the phenyl substituent. Also described are organic host materials that contain or that are coated with such compounds. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., spiro(indoline) type compounds, are also described.
摘要翻译： 描述了新颖的可逆性光致变色萘并吡喃化合物，其实例是在吡喃环的3位被（i）芳基取代基取代的化合物和（ii）具有5或6元杂环的苯基取代基， 苯基取代基的3和4个碳原子。 还描述了含有或被这种化合物涂覆的有机主体材料。 还描述了诸如将新型萘并吡喃化合物或其组合与诸如螺（二氢吲哚）类化合物的互补光致变色化合物结合的眼科镜片或其他塑料透明片。
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4.发明公开METHOD AND APPARATUS FOR REDUCING CATENARY DURING WINDING OF A FIBER BUNDLE 失效方法和装置玻璃纤维的减少缠绕过程中下垂BUNCH
公开(公告)号：EP0741665A1
公开(公告)日：1996-11-13
申请号：EP95910071.0
申请日：1994-12-15
申请人： PPG INDUSTRIES, INC.
CPC分类号： B65H51/015 , B65H51/10 , B65H54/026 , B65H57/28 , B65H59/16 , B65H59/38 , B65H2555/23 , B65H2701/31
摘要： The present invention relates to a method and apparatus for reducing catenary during winding of a fiber bundle (12, 112) which includes a plurality of fiber strands into a wound package. The method includes: applying substantially equal tension to each of a plurality of fiber strands; gathering the strands to form a bundle; advancing the bundle at a predetermined speed and tension toward a winding device; measuring the tension of the bundle; adjusting the tension of the bundle by adjusting the speed at which the bundle is advanced, such that (1) the speed of advancement of the bundle is increased when the measured tension of the bundle exceeds a predetermined value and (2) the speed of advancement of the bundle is decreased when the measured tension of the bundle is less than a second predetermined value; and winding the bundle to form a wound package. The apparatus includes a frame (26, 126); a plurality of fiber strands supply packages (20, 120); a plurality of tensioning devices (30, 130) for applying substantially equal tension to each of the fiber strands; a gathering device for gathering the fiber strands into a fiber bundle (12, 112); a feed device for advancing the fiber bundle at a predetermined speed to a winding device; a tension sensing device for determining the tension in the bundle and providing a signal to a feed device controller which adjusts the speed of the feed device in response to the signal from the tension sensing device; and a winding device.
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公开(公告)号：EP0713393A1
公开(公告)日：1996-05-29
申请号：EP94924120.0
申请日：1994-08-02
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The application discloses methods of making medicaments for treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of general formulae found above in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
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6.发明公开COMPOSITIONS AND METHODS FOR TREATING CANCER AND HYPERPROLIFERATIVE DISORDERS 失效筹备和方法用于治疗癌症和增殖性疾病治疗的
公开(公告)号：EP0702563A1
公开(公告)日：1996-03-27
申请号：EP94918667.0
申请日：1994-05-26
申请人： EntreMed, Inc.
发明人： NACY, Carol A. , HOLADAY, John W.
CPC分类号： B82Y5/00 , A61K9/127 , A61K39/0005 , A61K39/0011 , A61K2039/5258 , A61K2039/55555 , C07K16/22
摘要： The present invention encompasses methods for reducing or inhibiting growth factor in cancer cells and tissues. More particularly immunogenic growth factor-containing compositions are administered to a human or animal with a cancer or tumor. The immunogenic compositions elicit the production of antibodies specific for growth factor which reduce the level or circulating growth factor, thus reducing or eliminating the proliferation of cancer. The present invention encompasses growth factor-containing liposomes and vesicles having portions of growth factor externally presented on their surfaces. The present invention also includes antibodies specific for growth factor. Thus, according to the present invention, growth factor levels are reduced either by active immunization of an individual using immunogenic growth factor-containing compositions or by passive immunization via administering to the individual an antibody or a group of antibodies specific for growth factor.
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7.发明公开
公开(公告)号：EP0771333A1
公开(公告)日：1997-05-07
申请号：EP95925523.0
申请日：1995-07-06
申请人： PPG INDUSTRIES, INC.
发明人： WILT, Truman, F. , CARNEY, James, M. , THOMAS, Stephen, J. , CLAAR, James, A. , BIRKMEYER, William, J.
CPC分类号： C08G18/4288 , C08G18/423 , C08G18/792 , C09D175/06
摘要： An automotive refinish coating composition having a volatile organic content not exceeding 3.0 pounds per gallon contains a hydroxyl functional polyester and a polyisocyanate curing agent. The hydroxyl functional polyester is prepared from reactants containing: (A) from about 15 percent to about 50 percent of a polyol or mixture of polyols, each having a formula molecular weight from about 50 to about 2,000; (B) from about 15 percent to about 50 percent of a long chain monocarboxylic acid or mixture of such acids, each having from about 6 to 24 carbon atoms; and (C) from about 15 percent to about 30 percent of 1,4-cyclohexane dicarboxylic acid; the percentages based on the total weight of reactants used in preparing the polyester. The refinish coating composition is particularly suitable as a clear topcoat over a pigmented basecoat.
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公开(公告)号：EP0736000A1
公开(公告)日：1996-10-09
申请号：EP95903562.0
申请日：1994-11-15
CPC分类号： C07C213/02
摘要： A method of producing 4,6-diaminoresorcinol comprising: a) reducing a dinitroarylether of formula (I), wherein R is hydrogen, C1-C6 alkyl, cycloalkyl or CH=CH2, R' is hydrogen or CH2-R, each A is independently Cl, Br, or l, and n is 0, 1 or 2; to form a diaminoarylether; and b) cleaving the ether group(s) from the diaminoarylether under conditions such that 4,6-diaminoresorcinol is formed as a salt or other stabilized form thereof.
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公开(公告)号：EP0714305A1
公开(公告)日：1996-06-05
申请号：EP94924677.0
申请日：1994-08-26
申请人： VETREPHARM, INC.
IPC分类号： A61K35
CPC分类号： A61K35/74
摘要： The present invention relates to an immunostimulant composition and method of use that is effective for increasing reproductive performance in an animal or human. More particularly, the present invention is the use of a mycobacterial cell wall preparation for stimulating the immune system of an animal or human in such a way as to cause an increase in reproductive performance of the animal or human.
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公开(公告)号：EP0740708A1
公开(公告)日：1996-11-06
申请号：EP95904188.0
申请日：1994-11-28
申请人： Hendry, Lawrence B.
发明人： Hendry, Lawrence B.
CPC分类号： C12Q1/6811 , G06F19/16 , G06F19/706
摘要： It has been discovered that the degree of hormonal activity of candidate ligands correlates better with degree of fit into DNA than with the strength of receptor binding, and that the receptors in the steroid/thyroid hormone/vitamin A and D family alter the physiochemical properties of DNA and in concert with other transcription factors facilitate insertion of the ligand into DNA. As a result, the magnitude of the response is a function of the structure of the ligand as it related to insertion and fit into the DNA and the specificity of the response is a function of the stereochemistry of the receptor through binding to both the ligand and to the DNA. Based on these discoveries, a method is described herein for identifying drugs having increased activity as compared with the natural ligand for receptors such as the estrogenic receptors.
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