摘要:
The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of formula (I) and especially their use as inhibitors of the plasmodium falciparum protease plasmepsin II or related aspartic proteases.
摘要:
The invention relates to compositions in the form of a powder or granules comprising L-ascorbic acid and/or a pharmaceutically acceptable salt thereof, and pectin in a quantity within the range of about 0.1 to about 10% by weight.
摘要:
Epigallocatechin gallate (EGCG) is obtained by subjecting a green tea extract to chromatography on a macroporous polar resin; eluting EGCG from the resin with a polar elution solvent; optionally concentrating the eluate; optionally regenerating the resin by desorbing the remaining catechins; and optionally concentrating the desorbed catechins.
摘要:
The invention relates to a photostable cosmetic or pharmaceutical light screening composition containing a dibenzoyl methane UV-A screening agent and a p-methoxycinnamate UV-B screening agent, one of said agents being incorporated into a polymer latex; and, optionally, other conventional UV-A and UV-B screening agents. Furthermore the invention relates to a method of photostabilizing dibenzoyl methane UV-A screening agents and p-methoxycinnamate UV-B screening agents when used together, by incorporating one of these agents into a polymer latex.
摘要:
The invention relates to a process for preparing a highly loaded adsorbent, which process comprises the steps of
a) extracting an oil from an oil crude product by means of supercritical fluid extraction thus, obtaining a loaded supercritical fluid (SCF); b) expanding the loaded SCF of step a) followed by heating to obtain a liquid phase and a in-loading reduced SCF phase; c) optionally decreasing the pressure and/ or raising the temperature of the SCF phase of step b) to conditions of adsorption; d) introducing the SCF of step b) or step c) into a fixed bed adsorber to obtain an adsorbent loaded with the purified oil and pure SCF; e) feeding the liquid phase of step b) as a reflux to the extraction device of step a) ; f) compressing and tempering the pure SCF of step d) to extraction conditions; g) recycling the pure SCF to the extraction device of step a).
The invention further comprises a process for purifying an oil from an oil crude product by desorbing the adsorbed oil. The invention further comprises 16 A process for purifying an oil, optionally combined with a process for preparing a highly loaded adsorbent, which process comprises the steps of:
A) extracting a fraction containing the oil together with high volatile components from a crude synthetic or natural oil mixture by means of supercritical fluid extraction (SFE) thus, obtaining a loaded supercritical fluid (SCF) and a raffinate containing the low volatile components of the crude product; B) expanding the loaded SCF of step A) followed by heating to obtain a liquid phase containing the oil and high volatile components and an unloaded gas phase (step B-1) or to obtain an in-loading reduced SCF and a liquid phase (step B-2); C) optionally decreasing the pressure and/ or raising the temperature of the in-loading reduced SCF phase of step B-2) to conditions of adsorption; D) optionally introducing the in-loading reduced SCF of step B-2) or of step C) into a fixed bed adsorber to obtain an unloaded gas phase and an adsorbent loaded with oil; E) collecting the unloaded gas phase of step B-1) or of step D) in a vessel and controlling the content of the gas components; F) optionally feeding pure gas into the vessel of step E) to guarantee the same gas composition over the whole process time; G) feeding part of the liquid phase of step B-1) or all of the liquid phase of step B-2) at the same temperature and pressure of the column as a reflux to the extraction device of step A); H) pressurizing the gas phase of step E) or of step F) followed by cooling to separation conditions; I) recycling the SCF of step H to the extraction device of step A); J) optionally feeding the liquid phase of step B-1) to a second extraction device; K) extracting a fraction of high volatile components from the extract of step B-1) by means of SFE thus obtaining a loaded SCF and the pure oil as raffinate; L) treating the reflux and the SCF as described in the steps B-1 - I); M) collecting the oil at the bottom of the column as a raffinate.
摘要:
The present invention is directed to genetic materials useful for the preparation of astaxanthin from beta-carotene, such as polypeptides having astaxanthin synthase activity, DNA fragments coding for astaxanthin synthase, recombinant organisms and the like. Those novel genetic materials may be originated from Phaffia rhodozyma. The present invention also provides a process for the production of astaxanthin.