公开(公告)号：EP1159051A1

公开(公告)日：2001-12-05

申请号：EP99968200.8

申请日：1999-12-30

申请人： Cardiovention, Inc.

发明人： DUERI, Jean-Pierre ,  JOCHIM, Robert ,  LEYNOV, Alex

IPC分类号： B01D24/28

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1029 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366

摘要： An integrated blood pump (110), oxygenator, and heat exchanger is provided having a rotating hollow fiber bundle (115) assembly. A plurality of vanes arranged along a central shaft (124) of the device increase pressure near the center of the fiber bundle (115) to develop sufficient pressure head to pump the blood through the heat exchanger. In alternative embodiments, the heat exchanger comprises a pleated metal wall, a bundle of non-permeable hollow fibers (115), or a coiled tube (130) disposed between the rotating hollow fiber bundle (115), and an interior wall of the housing (113).

公开(公告)号：EP1093386A4

公开(公告)日：2004-06-30

申请号：EP99931903

申请日：1999-06-24

申请人： CARDIOVENTION INC

发明人： AFZAL THOMAS A

IPC分类号： A61M25/00 ,  A61M29/00

CPC分类号： A61M25/007 ,  A61M25/0032 ,  A61M2025/0004 ,  A61M2025/0036 ,  A61M2025/1052 ,  A61M2210/127

摘要： Apparatus and methods are provided for delivering oxygenated blood at a first flow rate to a first region of the body, and at a second lower flow rate to a second region of the body, using first balloons, second balloons (13, 15), a first lumen (23) that delivers blood to a first plurality of apertures (14) interposed between the first and second balloons.

公开(公告)号：EP1357957A2

公开(公告)日：2003-11-05

申请号：EP02709395.4

申请日：2002-02-08

申请人： Cardiovention, Inc.

发明人： STRINGER, Steven, K. ,  HULTQUIST, Kevin, L. ,  FARHANGNIA, Mehrdad ,  BRIAN, Ben, F., III ,  LINKER, Fred, I. ,  CULP, James, M. ,  DUERI, Jean-Pierre ,  AFZAL, Thomas, A.

IPC分类号： A61M1/14

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3666 ,  Y10S261/28

摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit (31) is provided in which a gas removal/blood filter (56), pump (55) and blood oxygenation element (70) are mounted within a common housing (40). The gas removal system includes a sensor (37) mounted on the housing to sense the presence of gas, and a valve (36) is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

摘要翻译： 提供用于泵送和充氧血液的装置和方法，其包括气体去除系统。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体的积聚时，阀可操作地耦合到传感器以从系统排出气体。

公开(公告)号：EP1163035A1

公开(公告)日：2001-12-19

申请号：EP99967767.7

申请日：1999-12-30

申请人： Cardiovention, Inc.

发明人： FARHANGNIA, Mehrdad ,  LEYNOV, Alex ,  LOEFFLER, Joseph ,  PIPLANI, Alec, A. ,  POTTS, Greg ,  SKIELLER, Christian

IPC分类号： B01D24/28

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366 ,  Y10S261/28

摘要： An integrated blood pump/oxygenator (80) having a rotating hollow fiber bundle assembly (81) that both oxygenates, and pumps blood is provided that includes a plurality of partitions (82) (84) (85) disposed within or about the fiber bundle assembly (81) to lengthen the flow path of blood (87) (88) passing through the fiber bundle (81). Alternatively, or in addition, blood flow paths (87) (88) may be lengthened, oxygenation improved by providing internal recirculation paths within the pump/oxygenator, which also advantageously may be used to reduce blood trauma caused by stagnation nearing moving parts, and heat build-up.

公开(公告)号：EP1163034A1

公开(公告)日：2001-12-19

申请号：EP99967749.5

申请日：1999-12-30

申请人： Cardiovention, Inc.

发明人： AFZAL, Thomas, A. ,  DUERI, Jean-Pierre ,  LEYNOV, Alex ,  MAKAREWICZ, Anthony ,  PIPLANI, Alec, A. ,  POTTS, Greg

IPC分类号： B01D24/28

CPC分类号： A61M1/267 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M2205/366

摘要： Improvements to integrated blood pump/oxygenator (120) having a rotating hollow fiber bundle (127) assembly that both oxygenates, and pumps blood, are provided. An inner member arranged along a central axis of the device accelerates blood entering the fiber bundle (127) to reduce micro-bubble generation, and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle (127) are reduced by the addition of a reinforcement structure, while the gas flow path is configured to reduce flooding, and loss of oxygenation efficiency due to occasional rupture of fiber elements.

摘要翻译： 提供了具有旋转中空纤维束（127）组件的集成式血泵/充氧器（120）的改进，所述组件既充氧又泵送血液。 沿着装置的中心轴布置的内部构件加速血液进入纤维束（127）以减少微气泡的产生和血液创伤。 施加在纤维束（127）的纤维元件上的剪切载荷通过添加增强结构而减小，而气体流动路径被配置为减少淹水，并且由于纤维元件偶尔破裂而导致氧化效率的损失。

公开(公告)号：EP1624912A2

公开(公告)日：2006-02-15

申请号：EP04751333.8

申请日：2004-05-05

申请人： Cardiovention, Inc.

发明人： BRIAN, Ben, F., III ,  BUCKLEY, John, Thomas ,  DUERI, Jean-Pierre ,  FARHANGIA, Mehrdad ,  STRINGER, Steven, K.

IPC分类号： A61M1/14 ,  A61M37/00

CPC分类号： A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/084 ,  B01D19/0031 ,  Y10S128/03 ,  Y10S261/28

摘要： Apparatus (100) for oxygenating and pumping blood includes a housing defining a blood flow path including, in series, a gas collection plenum (72), a pump space (55) and a blood oxygenation element (70). A pump disposed in the pump space is configured to draw blood from the gas collection plenum and propel blood from the pump space through a heat exchanger (102) and the blood oxygenation element. The heat exchanger includes a heat exchange plate and a coolant space (103).

公开(公告)号：EP1603608A2

公开(公告)日：2005-12-14

申请号：EP04757624.4

申请日：2004-03-17

申请人： Cardiovention, Inc.

发明人： LITZIE, A. Kenneth ,  STRINGER, Steven, K. ,  FARHANGNIA, Mehrdad ,  TYEBJEE, Muslim ,  AFZAL, Thomas, A. ,  BRIAN, Ben, F., III

IPC分类号： A61M1/14

CPC分类号： A61M1/3629 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1029 ,  A61M1/1086 ,  A61M2027/004 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3334 ,  Y10S128/03

摘要： Apparatus (10) for processing blood in an extracorporeal circuit (110) with automatic flow control is provided in which error conditions are sensed and system operation is modulated responsive to the error conditions. The apparatus includes an extracorporeal blood processing system (31), at least one sensor (25-27) to sense the presence of gas or to monitor venous pressure, and a controller (33) operably coupled to the blood processing system to selectively reduce pump speed or reconfigure flow paths the blood processing system responsive to the sensor output.

公开(公告)号：EP1357959A1

公开(公告)日：2003-11-05

申请号：EP02704396.7

申请日：2002-02-08

申请人： Cardiovention, Inc.

发明人： STRINGER, Steven, K. ,  HULTQUIST, Kevin, L. ,  FARHANGNIA, Mehrdad ,  LINKER, Fred, I. ,  BRIAN, Ben, F., III

IPC分类号： A61M1/34 ,  A61M35/00 ,  B01D53/22 ,  B01D50/00

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3666 ,  Y10S128/03 ,  Y10S261/28 ,  Y10S417/902

摘要： Apparatus and methods for removing gas from a blood handling system. A filter apparatus (40) for monitoring and removing gas is provided comprising of a gas removal/blood filter (46), a sensor (45) to sense the presence of gas, and a valve (36) operably coupled to the sensor to evacuate gas from the apparatus when the sensor detects an accumulation of gas. When used with a previously known blood handling system, the present filter apparatus facilitates priming and the addition of additional blood handling elements during operation of the blood handling system.

摘要翻译： 从血液处理系统中除去气体的装置和方法。 提供了一种用于监测和去除气体的过滤装置，其包括气体去除/血液过滤器，用于感测气体的存在的传感器，以及当传感器检测到气体积聚时可操作地耦合到传感器以将气体从设备排出的气门 。 当与先前已知的血液处理系统一起使用时，本过滤装置有利于在血液处理系统的操作期间起动和添加额外的血液处理元件。

公开(公告)号：EP1105062A1

公开(公告)日：2001-06-13

申请号：EP99942192.8

申请日：1999-08-13

申请人： Cardiovention, Inc.

发明人： AFZAL, Thomas, A.

IPC分类号： A61B19/00 ,  A61M25/16 ,  A61M25/18 ,  A61M29/00 ,  A61M39/00

CPC分类号： A61B17/12109 ,  A61B17/12022 ,  A61B17/12136 ,  A61B2017/22067 ,  A61M25/04 ,  A61M25/1011

摘要： Apparatus, and methods are provided for delivering oxygenated blood to a patient undergoing cardiac surgery using a perfusion catheter (65) having a distal end carrying first (71), second (72) sealing members. When the perfusion catheter is inserted through an arteriotomy site, the first, and second sealing members are disposed to engage opposite sides of a vessel (A) to apply pressure against the opposite surfaces of the thickness to seal blood perfused into the vessel from leaking through the arteriotomy site. Apparatus for placing the perfusion catheter, and methods of using the apparatus are also provided.

公开(公告)号：EP1093386A1

公开(公告)日：2001-04-25

申请号：EP99931903.1

申请日：1999-06-24

申请人： Cardiovention, Inc.

发明人： AFZAL, Thomas, A.

IPC分类号： A61M29/00

CPC分类号： A61M25/007 ,  A61M25/0032 ,  A61M2025/0004 ,  A61M2025/0036 ,  A61M2025/1052 ,  A61M2210/127

摘要： Apparatus and methods are provided for delivering oxygenated blood at a first flow rate to a first region of the body, and at a second lower flow rate to a second region of the body, using first balloons, second balloons (13, 15), a first lumen (23) that delivers blood to a first plurality of apertures (14) interposed between the first and second balloons.