-
公开(公告)号：EP2548950B1
公开(公告)日：2017-10-25
申请号：EP12177512.6
申请日：2010-06-04
发明人： Brown, Matthew , Dominguez, Elizabeth, Rondon , Learish, Randy , Nuwaysir, Emile , Rajesh, Deepika , Mack, Amanda
IPC分类号： C12N5/074 , C12N5/0783 , C12N15/85
CPC分类号： C12N5/0696 , C12N5/0637 , C12N15/85 , C12N2501/2302 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2502/1114 , C12N2506/11 , C12N2510/00 , C12N2800/108
摘要： Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34 + hematopoietic cells, such as human CD34 + blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement ofT cell receptors.
-
2.发明授权A COMPENDIUM OF READY-BUILT STEM CELL MODELS FOR INTERROGATION OF BIOLOGICAL RESPONSE 有权用于生物反应介入的备用干细胞模型回顾
公开(公告)号：EP2582793B1
公开(公告)日：2017-09-06
申请号：EP11796365.2
申请日：2011-06-15
CPC分类号： G01N33/5023 , G01N33/5014 , G01N33/5041 , G01N33/5073
-
3.发明公开METHODS AND COMPOSITIONS FOR CULTURING ENDODERM PROGENITOR CELLS IN SUSPENSION 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR KULTIVIERUNG VON ENDODERM-VORLÄUFERZELLENIN EINER SUSPENSION
公开(公告)号：EP2981605A1
公开(公告)日：2016-02-10
申请号：EP14724590.6
申请日：2014-04-03
CPC分类号： C12N5/0676 , C12N5/0607 , C12N5/0696 , C12N2500/02 , C12N2500/90 , C12N2500/92 , C12N2500/98 , C12N2501/10 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2501/33 , C12N2501/415 , C12N2501/999 , C12N2506/45
摘要： Provided herein are methods for the in vitro differentiation of induced pluripotent stem cells, which have been expanded and/or maintained under defined conditions, into endodermal precursor cells (EPCs) that are capable of producing mono-hormonal beta cells.
摘要翻译： 本文提供了将已经在限定条件下扩增和/或维持的诱导多能干细胞体外分化成能够产生单一激素β细胞的内胚层前体细胞（EPCs）的方法。
-
公开(公告)号：EP2470673B1
公开(公告)日：2014-07-30
申请号：EP10748206.9
申请日：2010-08-26
发明人： THOMSON, James , SEAY, Nick
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
-
公开(公告)号：EP2732029A1
公开(公告)日：2014-05-21
申请号：EP12736042.8
申请日：2012-07-11
IPC分类号： C12N5/073
CPC分类号： C12N5/0696 , C12N15/907 , C12N2501/15 , C12N2501/235 , C12N2501/415 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/1307
摘要： Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.
摘要翻译： 提供了产生工程诱导多能干（iPS）细胞的方法，包括将第一核酸导入体细胞以整合到其基因组中并重编程细胞以产生具有整合到其基因组中的核酸的工程化iPS细胞。 例如，在某些方面，通过引入表达一种或多种重编程因子的遗传元件并在足以产生重编程细胞的条件下培养细胞来重编程细胞。
-
公开(公告)号：EP2694644A2
公开(公告)日：2014-02-12
申请号：EP12764571.1
申请日：2012-03-30
CPC分类号： C12N5/0619 , A61K35/12 , A61K35/30 , C12N5/0622 , C12N2501/119 , C12N2501/155 , C12N2506/45
摘要： Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including priming stem cells for neural differentiation in a culture medium essentially free of growth factors such as FGF and TGFβ. As an advantage, the neural cells may be provided with improved consistency and purity.
-
公开(公告)号：EP2582792A2
公开(公告)日：2013-04-24
申请号：EP11796584.8
申请日：2011-06-20
发明人： MEYER, Nathan , SWANSON, Brad , FIENE, Steve
CPC分类号： C12N5/0657 , C12N2500/00 , C12N2501/999
摘要： Methods and composition for maintenance of cardiomyocytes are provided. For example, in certain aspects methods including culturing the cardiomyocytes in a medium essentially free of serum or containing dialyzed serum to maintain long-term purity. In further aspects, methods for modulation of cardiomyocytes may be provided.
摘要翻译： 提供了用于维持心肌细胞的方法和组合物。 例如，在某些方面，包括在基本不含血清或含有透析血清的培养基中培养心肌细胞以维持长期纯度。 在另外的方面，可以提供用于调节心肌细胞的方法。
-
公开(公告)号：EP2470673A1
公开(公告)日：2012-07-04
申请号：EP10748206.9
申请日：2010-08-26
发明人： THOMSON, James , SEAY, Nick
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： Methods for the determination of tissue-specific genetic variation are provided. For example, in certain aspects methods for using iPS cell-derived specific cell types for differential molecular analysis of tissue-specific genetic variation are described.
-
公开(公告)号：EP2490701B1
公开(公告)日：2017-08-02
申请号：EP10828771.5
申请日：2010-10-19
IPC分类号： C12N5/077
CPC分类号： C12N5/0657 , A61K48/00 , C07H21/04 , C07K14/475 , C07K14/50 , C12N5/0606 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/48 , C12N2501/70 , C12N2501/727 , C12N2506/02 , C12N2506/45 , C12N2509/00 , C12N2510/00
摘要： Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.
-
公开(公告)号：EP2291511B1
公开(公告)日：2017-06-21
申请号：EP09740008.9
申请日：2009-05-04
发明人： DAIGH, Christine , RAJESH, Deepika
IPC分类号： C12N5/0787
CPC分类号： C12N5/0642 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2502/1394 , C12N2506/02 , C12N2509/00
-
-
-
-
-
-
-
-
-
搜索结果
51 条记录 (耗时 0.03 秒)
