公开(公告)号：EP2467474A1

公开(公告)日：2012-06-27

申请号：EP10744699.9

申请日：2010-08-18

申请人： Danisco A/S ,  Danisco US Inc.

发明人： DEGN, Peter, Edvard ,  BOTT, Richard ,  VROEMEN, Casper, Willem ,  SCHEFFERS, Martijn, Silvan ,  AEHLE, Wolfgang

IPC分类号： C12N9/34 ,  C13K1/06

CPC分类号： C12N9/2408 ,  A23L29/35 ,  C12C5/004 ,  C12C7/04 ,  C12N9/2428 ,  C12P19/02 ,  C12P19/20 ,  C12Y302/01003 ,  C13K1/06 ,  Y02P20/52

摘要： The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.

公开(公告)号：EP2238244A1

公开(公告)日：2010-10-13

申请号：EP08866773.8

申请日：2008-12-30

申请人： Danisco A/S ,  Danisco US, Inc., Genencor Division

发明人： KRAGH, Karsten, Matthias ,  KELLET-SMITH, Anja Hemmingsen ,  SHAW, Andrew ,  CHIN, Regina

IPC分类号： C12N9/28 ,  A21D8/04 ,  A23L1/09

CPC分类号： C12N9/2417 ,  A21D8/042 ,  A23L29/35 ,  Y02E50/16 ,  Y02E50/17

摘要： Pseudomonas saccharophila G4-forming amylase (PS4) variants, and nucleic acids encoding these, and their uses in producing food products and in an enzyme-catalyzed high temperature liquefaction step to produce ethanol from starch, e.g., cornstarch are provided.

公开(公告)号：EP1641925A1

公开(公告)日：2006-04-05

申请号：EP04744138.1

申请日：2004-07-07

申请人： Danisco A/S, Danisco Intellectual Capital

发明人： KRAGH, Karsten, Matthias ,  SORENSEN, Bo, Spange

IPC分类号： C12N9/28 ,  A23L1/03 ,  A21D8/04

CPC分类号： C12N9/2417 ,  A21D8/042 ,  A23L29/06 ,  A23L29/35 ,  A23L33/17 ,  A23V2002/00 ,  A23V2300/21

摘要： We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.

公开(公告)号：EP0833922A1

公开(公告)日：1998-04-08

申请号：EP96921151.0

申请日：1996-06-24

申请人： DANISCO INGREDIENTS A/S (DANISCO A/S)

发明人： DE GRAAFF, Leendert, Hendrik ,  VAN DEN BROECK, Henri[tte, Catharina ,  VISSER, Jacob

IPC分类号： C12N15 ,  C07K14 ,  C12N1 ,  C12N9 ,  C12Q1

CPC分类号： C12N15/635 ,  C07K14/38 ,  C07K14/4705 ,  C12N9/0006 ,  C12N9/2434 ,  C12N9/248 ,  C12N9/88 ,  C12N15/1027 ,  C12N15/63 ,  C12N15/65 ,  C12N15/80 ,  C12Q1/02 ,  C12Y302/01003 ,  C12Y302/01008 ,  C12Y302/01015 ,  C12Y302/01037 ,  C12Y302/01055 ,  C12Y302/01099

摘要： The subject invention lies in the field of microorganism mutation and selection of the mutants. In particular, the invention is directed at obtaining metabolic mutants in a simple, direct and specific manner. In a preferred embodiment it is also possible to obtain desired mutants not comprising recombinant DNA, thereby facilitating incorporation thereof in products for human consumption or application, due to shorter legislative procedures. The method according to the invention involves random mutation and specific selection of the desired metabolic mutant. A nucleic acid cassette comprising a nucleic acid sequence encoding a bidirectional marker, said nucleic acid cassette further comprising a basic transcriptional unit operatively linked to the nucleic acid sequence encoding the bidirectional marker and said nucleic acid cassette further comprising an inducible enhancer or activator sequence linked to the basic transcription unit in such a manner that upon induction of the enhancer or activator sequence the bidirectional marker encoding nucleic acid sequence is expressed, said inducible enhancer or activator sequence being derived from a gene associated with activity of part of metabolism, said inducible enhancer or activator sequence being derived from a gene associated with metabolism is claimed as is application thereof in a selection method for mutants. In addition a regulator gene x1nR encoding an activating regulator of an inducible enhancer or activator sequence and application of said gene and/or its expression product in overexpression of homologous or heterologous protein or peptide is described. Knockout mutants wherein said gene is absent or inactivated and mutants with increased or decreased DNA binding capacity are also claimed.

公开(公告)号：EP1641925B1

公开(公告)日：2008-09-17

申请号：EP04744138.1

申请日：2004-07-07

申请人： Danisco A/S, Danisco Intellectual Capital

发明人： KRAGH, Karsten, Matthias ,  SORENSEN, Bo, Spange

IPC分类号： C12N9/28 ,  A23L1/03 ,  A21D8/04

CPC分类号： C12N9/2417 ,  A21D8/042 ,  A23L29/06 ,  A23L29/35 ,  A23L33/17 ,  A23V2002/00 ,  A23V2300/21

摘要： We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.

公开(公告)号：EP1711064A1

公开(公告)日：2006-10-18

申请号：EP05707851.1

申请日：2005-01-26

申请人： Danisco A/S, Danisco Intellectual Capital

发明人： WILLIAMS, Graham ,  DELVES-BROUGHTON, Joss ,  FARAGHER, John ,  SALMELA, Diane ,  HARDY, Jay ,  HAUGAN, Kersti ,  THOMAS, Linda ,  WISLER, Peter 3-01, Mont Kiara Damai, 3 Jalan

IPC分类号： A21D15/08 ,  A23L3/3463

CPC分类号： A23L3/34635 ,  A21D15/08

摘要： The present invention relates to a non yeast-leavened fine bakery product with increased shelf life and to a process for increasing the shelf life of intermediate and high moisture fine bakery products. The fine bakery product comprises an intermediate or high moisture baked product having a water activity aw >0.8. Its surface has deposited thereon an effective amount of natamycin, which is sufficient to keep the product mould free when packaged for a storage time of 2 weeks or more at ambient temperature. In the process the outer surface of a baked product is sprayed with natamycin to deposit an effective amount of natamycin thereon, whereafter the sprayed product is packaged in a protective envelope.

公开(公告)号：EP4395805A1

公开(公告)日：2024-07-10

申请号：EP22782799.5

申请日：2022-09-02

申请人： International N&H Denmark ApS ,  Danisco US Inc. ,  Danisco Deutschland GmbH ,  Nutrition & Biosciences USA 4, Inc.

发明人： MOROVIC, Wesley, William ,  PETERSON, Jonathan, David ,  BUDINOFF, Charles ,  GUERY, Sebastien

IPC分类号： A61K38/08 ,  A61K38/10 ,  A61P31/14

CPC分类号： A61K38/08 ,  A61K38/10 ,  A61P31/14

公开(公告)号：EP2032148A2

公开(公告)日：2009-03-11

申请号：EP07804900.4

申请日：2007-05-11

申请人： Danisco A/S, Danisco Intellectual Capital

发明人： OUWEHAND, Arthur ,  DESREUMAUX, Pierre ,  CARCANO, Didier

IPC分类号： A61K35/74 ,  A61K36/185 ,  A61K31/485 ,  A61K31/352 ,  A61K45/06

CPC分类号： A61K45/06 ,  A23L33/10 ,  A23L33/135 ,  A61K31/352 ,  A61K31/485 ,  A61K35/747 ,  A61K2300/00

摘要： The present invention relates to a composition comprising: i) at least one strain of a Lactobacillus sp and/or a metabolite thereof; and ii) a cannabinoid receptor agonist and/or a opioid receptor agonist. In addition, the present invention relates to methods using and uses of such a composition.

公开(公告)号：EP1907538A1

公开(公告)日：2008-04-09

申请号：EP06755730.6

申请日：2006-07-07

申请人： Danisco A/S, Danisco Intellectual Capital ,  GENENCOR INTERNATIONAL, INC.

发明人： BERG, Casper, Tune ,  DERKX, Patrick, Maria, Franciscus ,  FIORESI, Carol ,  GERRITSE, Gijsbert ,  KELLET-SMITH, Anja, Hemmingen ,  KRAGH, Karsten, Matthias ,  LIU,Wei ,  SHAW, Andrew ,  SØRENSEN, Bo, Spange ,  THOUDAHL, Charlotte, Refdahl

IPC分类号： C12N9/28

CPC分类号： A21D8/042 ,  A23L33/18 ,  C12N9/2411 ,  C12N9/2414 ,  C12N9/2417 ,  C12N9/2425 ,  C12N9/2428

摘要： We describe a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1 , uses of such a polypeptide as a food or feed additive, and nucleic acids encoding such.

公开(公告)号：EP1817298A2

公开(公告)日：2007-08-15

申请号：EP05800280.9

申请日：2005-10-25

申请人： Danisco A/S, Danisco Intellectual Capital

发明人： WIEBE, Lars ,  SCHMIDT, Thomas

IPC分类号： C07D315/00

CPC分类号： C07D315/00 ,  A23L27/203 ,  C07D309/30

摘要： The present invention relates to a process for preparing a lactone. The process comprises the steps of reacting an aldehyde with an organic halide in a carbon chain extension reaction to form an alcohol compound comprising a functional group capable of allowing for carbonylation of said alcohol compound, and then reacting said alcohol compound in a carbonylation reaction to form an hydroxycarboxylic acid; and cyclising the hydroxycarboxylic acid to produce the lactone.