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1.发明公开SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL 有权山梨酸和苯甲酸以及它们的衍生物，以加强NEURO前药的影响
公开(公告)号：EP2389187A4
公开(公告)日：2013-12-04
申请号：EP10733788
申请日：2010-01-19
发明人： TSAI GUOCHUAN EMIL
IPC分类号： A61K31/192 , A61K31/19 , A61K31/196 , A61K31/22 , A61K31/235 , A61K31/245 , A61K45/06 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28
CPC分类号： A61K31/47 , A61K31/11 , A61K31/12 , A61K31/13 , A61K31/16 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/22 , A61K31/235 , A61K31/245 , A61K31/27 , A61K31/35 , A61K31/382 , A61K31/438 , A61K31/445 , A61K31/5513 , A61K33/00 , A61K36/16 , A61K45/06 , A61K2300/00
摘要： Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder ( e . g ., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc .) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent ( e . g ., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc. ) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.
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2.发明公开PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开药物组合物和疫苗接种方法播散性念珠菌病及其他传染性病原体
公开(公告)号：EP1883421A4
公开(公告)日：2009-12-16
申请号：EP06752341
申请日：2006-05-04
发明人： EDWARDS JR JOHN E , FILLER SCOTT G , SHEPPARD DONALD C , IBRAHIM ASHRAF , FU YUE , SPELLBERG BRAD J , YEAMAN MICHAEL
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/40 , C07K16/14
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3.发明公开DIAGNOSIS AND THERAPY OF ANTIBODY-MEDIATED INFLAMMATORY AUTOIMMUNE DISORDERS 审中-公开诊断和抗体的治疗介导的炎性自身免疫性疾病
公开(公告)号：EP1469879A4
公开(公告)日：2008-02-27
申请号：EP03710635
申请日：2003-01-03
CPC分类号： C07K16/2869 , A61K2039/505 , C07K16/244
摘要： The invention provides a method of reducing the severity of an autoimmune condition associated with T-lymphocyte infiltration. The invention also provides a method of diagnosing or predicting the susceptibility to an autoimmune disease associated with fibroblast mediated T-lymphocyte infiltration. Methods of identifying a substance capable of modulating T-lymphocyte recruitment associated with an autoimmune condition also are provided.
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4.发明公开COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST DRUG RESISTANT ACINETOBACTER BAUMANNII 审中-公开组合物和方法免疫对药物产生耐药鲍曼不动杆菌
公开(公告)号：EP2707023A4
公开(公告)日：2015-09-09
申请号：EP12785706
申请日：2012-05-11
发明人： SPELLBERG BRAD J , LIN LIN , IBRAHIM ASHRAF S , LUO GUANPINGSHENG
IPC分类号： A61K39/02 , A61K39/395 , A61P31/04 , A61P37/04 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/21 , C07K16/12 , C12N15/31 , C12N15/63
CPC分类号： C07K14/22 , A61K39/02 , A61K39/104 , A61K2039/55505 , C07K14/212 , C07K16/1203 , C07K16/1217 , C07K2317/34
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5.发明公开METHODS AND COPOSITIONS FOR VACCINATING AGAINST STAPHYLOCOCCUS AUREUS 有权VERFAHREN UND ZUSAMMENSETZUNGEN ZUR IMPFUNG GEGEN STAPHYLOCOCCUS AUREUS
公开(公告)号：EP2734229A4
公开(公告)日：2015-01-21
申请号：EP12817530
申请日：2012-07-20
发明人： YEAMAN MICHAEL R , EDWARDS JOHN E JR , FILLER SCOTT G , IBRAHIM ASHRAF S , FU YUE , HENNESSEY JOHN P JR
IPC分类号： A61K39/00
CPC分类号： A61K39/0002 , A61K45/06 , A61K2039/55505 , A61K2039/58
摘要： The invention features a method of vaccinating a mammal against Staphylococcus aureus which includes the steps of: a) identifying a mammal at risk for the development of a Staphylococcus aureus skin or soft tissue infection; and b) administering to said mammal an immunogenic amount of a vaccine that includes a polypeptide including an isolated agglutinin-like sequence (Als) 3 protein (Als3p), or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译： 本发明的特征在于一种针对金黄色葡萄球菌接种哺乳动物的方法，其包括以下步骤：a）鉴定处于发生金黄色葡萄球菌皮肤或软组织感染风险的哺乳动物; 和b）向所述哺乳动物施用免疫原性量的疫苗，所述疫苗包括在药学上可接受的培养基中包含分离的凝集素样序列（Als）3蛋白（Als3p）或其免疫原性片段的多肽。
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公开(公告)号：EP2049554A4
公开(公告)日：2011-06-29
申请号：EP07813152
申请日：2007-07-20
发明人： NOTTER ROBERT H , WANG ZHENGDONG , SCHWAN ADRIAN L , WANG ZHONGYI , DAVY JASON A , WARING ALAN J , WALTHER FRANS , GORDON LARRY M
CPC分类号： C07F9/091 , A61K9/0082 , C07F9/4006 , C07F9/4075 , C07K14/001 , C07K14/785
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7.发明公开
公开(公告)号：EP2812018A4
公开(公告)日：2016-10-19
申请号：EP13746107
申请日：2013-02-11
IPC分类号： A61K38/00 , A61K9/127 , C07K14/00 , C07K14/785
摘要： The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, naturally occurring phospholipids, or a combination thereof. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue and to deliver therapeutic agents are also disclosed.
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8.发明公开HYR1-DERIVED COMPOSITIONS AND METHODS OF TREATMENT USING SAME 审中-公开ZUSAMMENSETZUNGEN AUS HYR1 UND BEHANDLUNGSVERFAHREN DAMIT
公开(公告)号：EP2755668A4
公开(公告)日：2015-07-01
申请号：EP12832321
申请日：2012-09-14
CPC分类号： C07K14/40 , A61K39/00 , A61K39/0002 , A61K47/646 , A61K2039/6081 , C07K16/14
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公开(公告)号：EP2755681A4
公开(公告)日：2015-05-13
申请号：EP12831998
申请日：2012-09-14
发明人： IBRAHIM ASHRAF S , LIU MINGFU , GHEBREMARIAM TEKLEGIORGIS , FU YUE , EDWARDS JOHN E , FILLER SCOTT
CPC分类号： C07K16/14 , A61K2039/505 , C07K14/37 , C07K2317/24 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/56961 , G01N2333/37 , G01N2469/10
摘要： The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.
摘要翻译： 本发明提供了Mucorales CotH多肽并编码核酸分子。 Mucorales CotH多肽和编码核酸可有利地用于诊断，治疗或预防真菌病症，特别是毛霉菌病。
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10.发明公开PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 有权用于接种传播的念珠菌和其它感染剂的药物组合物和方法
公开(公告)号：EP1982190A4
公开(公告)日：2009-12-23
申请号：EP07709622
申请日：2007-01-05
发明人： EDWARDS JOHN E JR , FILLER SCOTT G , IBRAHIM ASHRAF , FU YUE , SPELLBERG BRAD J , YEAMAN MICHAEL
IPC分类号： G01N33/569 , C12N1/00 , C12Q1/14
CPC分类号： A61K39/0002 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
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