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1.发明公开DNA CONTROLLING miR-140 EXPRESSION, AND SCREENING METHOD OF DRUGS USING SAID DNA 审中-公开MIR-140-表达MIT DNA-STEUERUNG SOWIE ARZNEISTOFF-SCREENINGVERFAHREN MIT DIESER DNA
公开(公告)号：EP2835424A1
公开(公告)日：2015-02-11
申请号：EP13772453.0
申请日：2013-04-02
IPC分类号： C12N15/113 , A01K67/027 , A61K45/00 , A61P19/00 , A61P19/02 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5308 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/113 , C12N2310/141 , G01N2400/10 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： An object of the present invention is to provide DNA which regulates the expression of miR-140, a reporter vector which contains the DNA, cells and animals into which the reporter vector is introduced and a screening system for drugs which control the expression of miR-140 and is also to contribute in the development of new therapeutic agents for cartilage diseases such as osteoarthritis and intervertebral disk degeneration using the screening system.
The DNA sequence according to the present invention is able to express any gene in a site where miR-140 is expressed and, in addition, it is also able to be utilized for screening a drug which regulates the expression of miR-140. Moreover, the drug that is selected by the screening system of the present invention is expected as a therapeutic agent for cartilage diseases accompanied by abnormality of cartilage.摘要翻译： 本发明的目的是提供调节miR-140表达的DNA，该载体包含引入报道载体的DNA，细胞和动物，以及用于控制miR- 还有助于开发使用筛选系统的软骨疾病如骨关节炎和椎间盘退变的新治疗剂。 根据本发明的DNA序列能够在miR-140表达的位点中表达任何基因，此外，它还能够用于筛选调节miR-140表达的药物。 此外，预期本发明的筛选系统选择的药物是软骨异常伴随软骨疾病的治疗剂。
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公开(公告)号：EP2835424B1
公开(公告)日：2019-02-20
申请号：EP13772453.0
申请日：2013-04-02
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公开(公告)号：EP3120848B1
公开(公告)日：2018-09-26
申请号：EP15764236.4
申请日：2015-03-19
IPC分类号： A61K31/37 , A61P11/00 , A61P19/02 , A61P29/00 , C07D311/18 , C07D405/12 , C07D409/12
CPC分类号： A61K31/37 , A61K9/007 , A61K31/381 , A61K31/4433 , A61K31/635 , C07D311/12 , C07D311/18 , C07D405/12 , C07D409/12
摘要： An object of the present invention is to provide a preventive or therapeutic agent for inflammatory diseases or degenerative intervertebral disk diseases. A coumarin derivative or a pharmaceutically acceptable salt or hydrate thereof which is an active ingredient of the preventive or therapeutic agent of the present invention exhibits an excellent suppressive action in a pharmacological test where production of inflammation-related factor such as inflammatory cytokine or fibrosis-related factor as an index. Moreover, said compound also exhibits an excellent suppressive action to pulmonary fibrosis model animals and degenerative intervertebral disk disease model animals. Accordingly, the present invention is very useful as a preventive or therapeutic agent for inflammatory diseases and degenerative intervertebral disk diseases.
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4.发明公开PROPHYLACTIC OR THERAPEUTIC DRUG FOR PERIPHERAL NEUROPATHY CAUSED BY ANTICANCER AGENT 审中-公开PROPHYLAKTISCHES UNDEREREUTISCHES MITTELFÜRDURCH ANTIKREBSMITTEL VERURSACHTE PERIPHERE NEUROPATHIEN
公开(公告)号：EP2671578A1
公开(公告)日：2013-12-11
申请号：EP12742127.9
申请日：2012-01-30
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , OKADA, Tomoyuki , MATSUMOTO, Tomonori , SAWADA, Kazuyoshi
IPC分类号： A61K31/201 , A61P25/02
CPC分类号： C07C69/533 , A61K9/0019 , A61K9/0095 , A61K9/10 , A61K31/23 , A61K31/231 , A61K45/06 , A61K47/6951 , B82Y5/00
摘要： An object of the present invention is to provide a drug which is effective for prophylaxis or therapy of peripheral nerve disorder occurred as a side effect of the administration of anti-cancer agents.
The present invention is to provide a drug containing an ester of C 10 fatty acid as an active ingredient for prophylaxis or therapy of peripheral nerve disorder induced by administration of a drug containing at least one of anti-cancer agents. The drug of the present invention containing the compound as an active ingredient is highly useful as a drug for prophylaxis or therapy of peripheral nerve disorder induced by administration of anti-cancer agents.摘要翻译： 本发明的目的是提供一种对预防或治疗作为施用抗癌剂的副作用发生的周围神经障碍有效的药物。 本发明提供一种含有C 10脂肪酸的酯作为活性成分的药物，用于预防或治疗通过施用含有至少一种抗癌剂的药物而引起的周围神经障碍。 含有该化合物作为活性成分的本发明药物作为用于预防或治疗通过施用抗癌剂诱发的周围神经障碍的药物是非常有用的。
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公开(公告)号：EP2899187A1
公开(公告)日：2015-07-29
申请号：EP13838182.7
申请日：2013-09-20
IPC分类号： C07D311/18 , A61K31/352 , A61K31/381 , A61K31/4406 , A61P19/02 , A61P29/00 , C07D405/12 , C07D409/12
CPC分类号： C07D311/12 , A61K31/352 , C07D311/18 , C07D405/12 , C07D409/12
摘要： The purpose of the present invention is to provide a novel coumarin derivative or a pharmaceutically acceptable salt thereof and also to provide a pharmaceutical agent containing such a compound as an active ingredient.
The coumarin derivative of the present invention or a pharmaceutically acceptable salt thereof exhibits an excellent suppressive action to the destruction of cartilage and suppressive action to the proliferation of synovial cells in a pharmacological test where the release of sulfated glycosaminoglycans (sGAG) and the proliferation of synovial cells are used as indicators whereby it is very useful as an active ingredient of a pharmaceutical composition such as a preventive or therapeutic agent for arthropathy such as osteoarthritis or chronic rheumatoid arthritis.摘要翻译： 本发明的目的是提供一种新的香豆素衍生物或其药学上可接受的盐，并且提供含有这种化合物作为活性成分的药剂。 本发明的香豆素衍生物或其药学上可接受的盐在药理学试验中对软骨的破坏和对滑膜细胞的增殖的抑制作用显示出优异的抑制作用，其中硫酸化糖胺聚糖（sGAG）的释放和滑膜的增殖 细胞用作指示剂，其作为药物组合物的活性成分非常有用，例如关节病如骨关节炎或慢性类风湿性关节炎的预防或治疗剂。
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公开(公告)号：EP2842553A1
公开(公告)日：2015-03-04
申请号：EP13782289.6
申请日：2013-04-26
IPC分类号： A61K31/16 , A61K9/08 , A61K9/20 , A61K9/70 , A61K31/231 , A61K31/265 , A61K47/40 , A61P19/02 , A61P29/00
CPC分类号： A61K31/40 , A61K9/0019 , A61K9/0053 , A61K31/16 , A61K31/165 , A61K31/231 , A61K31/265 , A61K47/40 , A61K47/48969 , A61K47/6951
摘要： An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing at least one member selected from a trans-2-decenoic acid derivative represented by the formula (1) and a pharmaceutically acceptable salt thereof as an active ingredient:
(In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group). The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis).摘要翻译： 本发明的目的是提供对各种疼痛疾病的预防或治疗有效的止痛剂。 本发明提供含有选自式（1）所示的反式-2-癸烯酸衍生物及其药学上可接受的盐中的至少一种作为有效成分的止痛剂：（式中，Y为-O - ， - NR-或-S-，R为氢原子，烷基，二烷基氨基烷基等，W为取代基如二烷基氨基烷基）。 含有该化合物作为有效成分的本发明的止痛剂作为骨关节炎引起的疼痛等各种疼痛疾病（例如膝骨关节炎，髋骨关节炎）的预防或治疗剂非常有用。
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公开(公告)号：EP3421989A1
公开(公告)日：2019-01-02
申请号：EP17756664.3
申请日：2017-02-24
摘要： The object of the present invention is to provide a test method using a novel administration method of an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract.
It has been demonstrated that by sustainedly administering an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract by using a continuous administration device according to the present invention, a comparable effect is exerted at a very low dose compared with conventional administration methods such as oral administration. Therefore, the present invention can provide a test method using animals requiring less burden on a researcher, a treatment of patient at a low dose, and the like.-
公开(公告)号：EP2899187B1
公开(公告)日：2017-04-19
申请号：EP13838182.7
申请日：2013-09-20
IPC分类号： C07D311/12 , C07D311/18 , C07D317/12 , C07D405/12 , C07D409/12 , A61K31/352 , A61K31/381 , A61K31/4406 , A61P19/02 , A61P29/00
CPC分类号： C07D311/12 , A61K31/352 , C07D311/18 , C07D405/12 , C07D409/12
摘要： The purpose of the present invention is to provide a novel coumarin derivative or a pharmaceutically acceptable salt thereof and also to provide a pharmaceutical agent containing such a compound as an active ingredient. The coumarin derivative of the present invention or a pharmaceutically acceptable salt thereof exhibits an excellent suppressive action to the destruction of cartilage and suppressive action to the proliferation of synovial cells in a pharmacological test where the release of sulfated glycosaminoglycans (sGAG) and the proliferation of synovial cells are used as indicators whereby it is very useful as an active ingredient of a pharmaceutical composition such as a preventive or therapeutic agent for arthropathy such as osteoarthritis or chronic rheumatoid arthritis.
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公开(公告)号：EP2842942B1
公开(公告)日：2016-12-07
申请号：EP13781244.2
申请日：2013-04-26
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , MATSUMOTO, Tomonori , HIGASHIURA, Kunihiko
IPC分类号： C07D207/16 , A61K9/70 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K31/55 , A61K31/551 , A61K47/40 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/22
CPC分类号： C07D295/185 , C07D207/08 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/30 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/74 , C07D213/74 , C07D239/42 , C07D243/08 , C07D277/04 , C07D295/18
摘要： The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I): wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's diasease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.
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公开(公告)号：EP2842942A1
公开(公告)日：2015-03-04
申请号：EP13781244.2
申请日：2013-04-26
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , MATSUMOTO, Tomonori , HIGASHIURA, Kunihiko
IPC分类号： C07D207/16 , A61K9/70 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K31/55 , A61K31/551 , A61K47/40 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/22
CPC分类号： C07D295/185 , C07D207/08 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/30 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/74 , C07D213/74 , C07D239/42 , C07D243/08 , C07D277/04 , C07D295/18
摘要： The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I):
wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's diasease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.摘要翻译： 本发明涉及新型反式-2-癸烯酸衍生物或其药学上可接受的盐以及含有该化合物作为活性成分的药剂。 作为本发明化合物的反式-2-癸烯酸衍生物或其药学上可接受的盐具体由通式（I）表示：其中X是取代基，例如1-吡咯烷基，3-噻唑基 或哌啶子基，该化合物作为抗癌剂的给药诱导的周围神经障碍的预防或治疗剂，神经变性疾病的预防或治疗剂或痴呆等精神疾病的药剂非常有用 ，阿尔茨海默氏病，帕金森病，糖尿病性神经病，抑郁症，青光眼或自闭症谱，脊髓损伤的治疗剂或修复剂，针对各种疼痛疾病的镇痛剂等。
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