公开(公告)号：EP3105241A1

公开(公告)日：2016-12-21

申请号：EP15702805.1

申请日：2015-02-06

申请人： Organo Balance GmbH

发明人： LANG, Christine ,  LEWANDOWSKI, Anna

IPC分类号： C07H15/256 ,  C12N1/16 ,  C12N15/09

CPC分类号： C12N15/52 ,  C12N9/0042 ,  C12N9/0071 ,  C12N9/90 ,  C12N15/81 ,  C12P5/007 ,  C12P7/42 ,  C12P15/00 ,  C12Y106/02004 ,  C12Y504/99041

摘要： The invention relates to a yeast strain and to a method for microbial production of pentacyclic triterpenes and/or triterpenoids in yeast. More particularly, the invention relates to a modified yeast strain for production of pentacyclic triterpenoids comprising at least one copy of a gene for encoding an oxidosqualene cyclase, at least one copy of a gene for encoding an NADPH-cytochrome P450 reductase and/or at least one copy of a gene for encoding a cytochrome P450 monooxygenase.

摘要翻译： 本发明涉及一种酵母菌株和一种在酵母中微生物生产五环三萜烯和/或三萜类化合物的方法。 更具体地说，本发明涉及一种用于生产五环三萜类化合物的修饰酵母菌株，其包含至少一个编码氧化山梨烯环化酶的基因拷贝，用于编码NADPH-细胞色素P450还原酶的基因的至少一个拷贝和/或至少 编码细胞色素P450单加氧酶的基因的一个拷贝。

公开(公告)号：EP2150619A2

公开(公告)日：2010-02-10

申请号：EP08757965.2

申请日：2008-04-16

申请人： Organo Balance GmbH

发明人： LANG, Christine ,  VEEN, Markus ,  BÖTTNER, Mewes ,  RAAB, Andreas

IPC分类号： C12P7/46 ,  C12N1/19 ,  C12N9/04 ,  C12N9/88

CPC分类号： C12P7/46 ,  C12N1/18 ,  C12N9/0006 ,  C12N9/88

摘要： The invention relates to an isolated genetically modified microorganism in which the gene IDH1 and at least one of the genes SDH2 and DIC1 are under the control of a first promoter that is repressed to a growth culture medium by means of a cultivation additive and is active in the absence of the cultivation additive. The genes that are part of the group comprising 'PYC1, ACS1, CIT1, ACO1, ICL1, MSL1, and CIT2, optionally also MDH3' are constitutively active. The invention further relates to uses of such a microorganism, especially for producing succinic acid.

公开(公告)号：EP2108702A1

公开(公告)日：2009-10-14

申请号：EP08006915.6

申请日：2008-04-07

申请人： Organo Balance GmbH

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12P7/64 ,  C12N1/18 ,  A23L1/30 ,  A23K1/16

CPC分类号： C12P7/6472 ,  A23K20/158 ,  A23L33/12 ,  C11B1/10 ,  C12N1/18 ,  C12N9/0083 ,  C12N9/1029 ,  C12P7/6427

摘要： Described is a method of providing an organism belonging to the genus Saccharomyces, which is capable of producing polyunsaturated fatty acids (PUFAs) comprising the steps of subjecting such an organism, which does not produce PUFAs, to a mutagenesis step and selecting a Saccharomyces organism, which is capable of accumulating at least 15% of the cellular dry weight as lipids; and genetically modifying the Saccharomyces organism selected in step (a) so that it is capable of synthesizing PUFAs, in particular eicosapentaenoic acid and/or docosahexaenoic acid. Also described are organisms obtained by such a method, as well as a method for the synthesis of PUFAs, in particular eicosapentaenoic acid and/or docosahexaenoic acid comprising culturing such an organism.

摘要翻译： 描述了提供属于酵母属（Saccharomyces）的生物体的方法，其能够产生多不饱和脂肪酸（PUFAs），其包括将不产生PUFA的生物体进行诱变步骤并选择酵母属生物， 其能够以至少15％的细胞干重作为脂质积聚; 和遗传修饰在步骤（a）中选择的酵母属生物体，使得其能够合成PUFA，特别是二十碳五烯酸和/或二十二碳六烯酸。 还描述了通过这种方法获得的生物体，以及用于合成PUFA，特别是二十碳五烯酸和/或二十二碳六烯酸的方法，包括培养这种生物体。

公开(公告)号：EP1472354B1

公开(公告)日：2012-09-19

申请号：EP03701537.7

申请日：2003-01-22

申请人： Organo Balance GmbH

发明人： LANG, Christine ,  VEEN, Markus

IPC分类号： C12N15/52 ,  C12N15/81 ,  C12N9/90 ,  C12N9/02 ,  C12P33/00

CPC分类号： C12P33/00 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1007 ,  C12N9/90 ,  C12N15/52 ,  C12N15/81 ,  C12Y101/01088 ,  C12Y103/01072 ,  C12Y114/1307 ,  C12Y114/13132 ,  C12Y114/19 ,  C12Y201/01041 ,  C12Y503/03005

公开(公告)号：EP2673288B1

公开(公告)日：2016-10-05

申请号：EP12704706.6

申请日：2012-02-03

申请人： Organo Balance GmbH

发明人： LANG, Christine

IPC分类号： C07K5/02 ,  C07K5/08 ,  A61P17/00 ,  A61P17/02 ,  A61P17/16 ,  A61K8/64 ,  A61Q19/00

CPC分类号： A61K8/64 ,  A61K38/00 ,  A61Q5/02 ,  A61Q19/007 ,  A61Q19/10 ,  C07K5/0215 ,  C07K5/0815

公开(公告)号：EP2150619B1

公开(公告)日：2015-07-22

申请号：EP08757965.2

申请日：2008-04-16

申请人： Organo Balance GmbH

发明人： LANG, Christine ,  VEEN, Markus ,  BÖTTNER, Mewes ,  RAAB, Andreas

IPC分类号： C12P7/46 ,  C12N1/19 ,  C12N9/04 ,  C12N9/88

CPC分类号： C12P7/46 ,  C12N1/18 ,  C12N9/0006 ,  C12N9/88

公开(公告)号：EP2673288A1

公开(公告)日：2013-12-18

申请号：EP12704706.6

申请日：2012-02-03

申请人： Organo Balance GmbH

发明人： LANG, Christine

IPC分类号： C07K5/02 ,  C07K5/08 ,  A61P17/00 ,  A61P17/02 ,  A61P17/16

CPC分类号： A61K8/64 ,  A61K38/00 ,  A61Q5/02 ,  A61Q19/007 ,  A61Q19/10 ,  C07K5/0215 ,  C07K5/0815

摘要： The present invention relates to a peptide of the following formula (I) X1(X2)-X3-X4 or a salt or solvate thereof, wherein is an amino acid comprising two or more NH-functionalities, and X2, X3, and X4 are, independently from one another, an amino acid residue, and wherein the salt or solvate is preferably a physiologically acceptable salt or solvate.

公开(公告)号：EP2344656A1

公开(公告)日：2011-07-20

申请号：EP09748218.6

申请日：2009-10-07

申请人： Organo Balance GmbH

发明人： LANG, Christine ,  RAAB, Andreas

IPC分类号： C12P7/46 ,  C12N1/18 ,  C12N9/04 ,  C12R1/865

CPC分类号： C12P7/46 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1025 ,  C12N9/88 ,  C12N9/93 ,  C12Y101/01037 ,  C12Y101/01042 ,  C12Y103/05001 ,  C12Y203/03009 ,  C12Y401/03001 ,  C12Y602/01001

摘要： The invention relates to an isolated, genetically modified microorganism, wherein compared to the wild type a) the idh1 and idp1 genes have been deleted or inactivated, and/or b) the sdh2 and sdh1 genes have been deleted or inactivated, and/or c) the PDC2 gene has been deleted or inactivated or is under the control of a promoter which can be suppressed or induced by exposure of the microorganism using an inductor substance, and/or d) one or more genes from the group consisting of ICL1, MLS1, ACS1 and MDH3 has been replaced or supplemented by a corresponding foreign gene or corresponding foreign genes from Crabtree-negative organisms, and to the uses thereof.