摘要:
Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.
摘要:
(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.
摘要:
Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. (hemolyticus), are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. (aureus) and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.
摘要:
The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. Said compositions and methods enhance gestation and therefore improve neonatal morbidity and mortality.
摘要:
A fluid distribution device (1) comprising a reservoir (8); a pair of buckets (2), and a plurality of outlet pipes (6) for receiving the fluid discharged into the reservoir (8). Each bucket (2) is pivotable under gravity between a first receiving position in which it can receive fluid and a second discharge position in which it can release fluid contained therein into the reservoir (8). The buckets (2) are arranged such that when one bucket is located in the first receiving position, the other bucket is located in the second discharge position. The outlet pipes (6) are divided into two groups of equal number. located at opposite sides of the reservoir (8), and each group is arranged to receive the fluid from one of the buckets (2) when in the discharge position. Each outlet pipe (6) in a group receives an equal portion of the discharged fluid from its associated bucket. This may be achieved by fluid directing means.
摘要:
A sensor element suitable for colorimetric detection of anions in a sample, the sensor element comprising a water insoluble polymeric hydrogel having a polymer network defining a water permeable microvoid network, and an anion recognition dye (receptor) incorporated into the polymeric hydrogel. The anion recognition dye has a general formula (I),
Wherein R1, R2, R3 and R4 are each, independently, selected from H or an optionally substituted group consisting of lower alkyl, allyl, aryl, thioureas, urea, amide, ether, and X is S or O. An anion detection probe comprising a support that incorporates the sensor element and provided in the form of a dip-stick is also disclosed.
摘要:
The present invention provides compositions and methods for the suppression of Th2-mediated immune response. Tracheal cytotoxin is shown to mediate a selective suppression of T helper cell type 2 (Th2)-mediated immune responses. The methods and compositions of the invention are useful for the treatment of Th2-mediated diseases and conditions due to their utility in suppressing Th2-mediated immune responses. The invention further extends to methods for suppressing the production of cytokines, such as IL-4 and IL-5 which contribute to the development of Th2-mediated immune responses.
摘要:
A process for the preparation of modified nanoclay in one case comprises the steps of providing an organoclay, dispersing the organoclay in a solvent or mixture of solvents and/or surfactant, providing nariotubes or nanowires, dispersing the nanotubes or nanowires in a solvent or mixture of solvents and/or surfactant, and mixing the organoclay suspension with the nanotube and/or nanowire suspension. The organoclays modified with nanowires or nanotubes provide nanoadditives, which have enhanced thermal stability and electrical conductivity properties. The nanoadditive may include an inherently conducting polymer such as polyaniline. Also provided are polmyer composites including the nanoadditive.
摘要:
The present invention provides a composition for suppressing an inflammatory immune response comprising the excretory/secretory (ES) component of Fasciola hepatica or a fraction thereof. The composition has particular utility in the treatment or prophylaxis of T cell mediated inflammatory immune responses, and in particular autoimmune disease. The invention further extends to methods for modulating a T cell mediated immune response wherein a therapeutically effective amount of the excretory/secretory (ES) component from Fasciola hepatica is administered to a subject in need of such treatment in order to suppress the development of the response.
摘要:
A composite comprises a substrate and a fluoride, oxide, nitride or boride of a substantially non-magnetic cation on the substrate, the composite exhibiting ferromagnetic properties at room temperature. The composite may be in the form of a film.