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公开(公告)号：EP0574494A1
公开(公告)日：1993-12-22
申请号：EP92906944.0
申请日：1992-02-14
申请人： ABBOTT LABORATORIES
发明人： SUMMERS, James, B. , SHEPPARD, George, S. , PHILLIPS, James, G. , PIREH, Daisy , STEINMAN, Douglas, H. , MAY, Paul, D. , GUINN, Denise, E. , HEYMAN, H., Robin , CARRERA, George, M., Jr. , DAVIDSEN, Steven, K.
CPC分类号： C07D409/14 , C07D417/14
摘要： L'invention se rapporte à des composés d'indole, qui sont substitués aux positions 1 ou 3 par un groupe (pyrid-3-yl)thiazolid-4-yl alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- ou (pyrid-3-yl)dithiolan-4-oyl)- et qui constituent de puissants inhibiteurs du facteur d'activation des plaquettes et sont utiles dans le traitement des troubles associés au facteur d'activation des plaquettes, tels que choc septique, syndrome de la détresse respiratoire, inflammations aiguës, immunité cellulaire retardée, parturition, maturation des poumons du foetus et différenciation cellulaire.
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2.发明公开
公开(公告)号：EP1968979A2
公开(公告)日：2008-09-17
申请号：EP06839265.3
申请日：2006-12-08
申请人： ABBOTT LABORATORIES
发明人： MICHAELIDES, Michael, R. , MCCLELLAN, William, J. , FREY, Robin, R. , CURTIN, Michael, L. , STEINMAN, Douglas, H. , DAI, Yujia , HOLMS, James, H.
IPC分类号： C07D487/04 , C07D495/04 , A61K31/519 , A61P35/00
CPC分类号： C07F9/6561 , C07D487/04 , C07D495/04
摘要： Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating cancer using the compounds are disclosed.
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公开(公告)号：EP1147101B1
公开(公告)日：2002-11-20
申请号：EP00905758.9
申请日：2000-01-27
申请人： ABBOTT LABORATORIES
发明人： CURTIN, Michael, L. , DAI, Yujia , DAVIDSEN, Steven, K. , HEYMAN, Howard, R. , HOLMES, James, H. , MICHAELIDES, Michael, R. , STEINMAN, Douglas, H.
IPC分类号： C07D317/28 , C07D307/14 , C07D207/48 , C07D207/09 , C07D263/04 , A61K31/335 , A61P35/04
CPC分类号： C07D263/04 , C07D207/09 , C07D207/48 , C07D307/14 , C07D317/28
摘要： Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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4.发明公开
公开(公告)号：EP1001930A2
公开(公告)日：2000-05-24
申请号：EP98936014.4
申请日：1998-07-27
申请人： Abbott Laboratories
发明人： CURTIN, Michael, L. , DAVIDSEN, Steven, K. , DELLARIA, Joseph, F., Jr. , FLORJANCIC, Alan, S. , GIESLER, Jamie , GONG, Jianchun , GUO, Yan , HEYMAN, H., Robin , HOLMS, James, H. , MICHAELIDES, Michael, R. , STEINMAN, Douglas, H. , WADA, Carol, K. , XU, Lianhong
IPC分类号： C07C259/00
CPC分类号： C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：EP0874808B1
公开(公告)日：2003-04-09
申请号：EP96940406.0
申请日：1996-11-13
申请人： Abbott Laboratories
发明人： FESIK, Stephen, W. , SUMMERS, James, B., Jr. , DAVIDSEN, Steven, K. , SHEPPARD, George, S. , STEINMAN, Douglas, H. , CARRERA, George, M., Jr. , FLORJANCIC, Alan , HOLMS, James, H.
IPC分类号： C07C259/06 , A61K31/16
CPC分类号： C07C323/60 , C07C259/06
摘要： Compounds of formula (I), or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.
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6.发明授权
公开(公告)号：EP1001930B1
公开(公告)日：2002-12-04
申请号：EP98936014.4
申请日：1998-07-27
申请人： Abbott Laboratories
发明人： CURTIN, Michael, L. , DAVIDSEN, Steven, K. , DELLARIA, Joseph, F., Jr. , FLORJANCIC, Alan, S. , GIESLER, Jamie , GONG, Jianchun , GUO, Yan , HEYMAN, H., Robin , HOLMS, James, H. , MICHAELIDES, Michael, R. , STEINMAN, Douglas, H. , WADA, Carol, K. , XU, Lianhong
IPC分类号： C07C259/00
CPC分类号： C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：EP0595924B1
公开(公告)日：1999-04-14
申请号：EP92915895.4
申请日：1992-07-14
申请人： ABBOTT LABORATORIES
发明人： SUMMERS, James, B. , DAVIDSEN, Steven, K. , HOLMS, James, H. , PIREH, Daisy , HEYMAN, H., Robin , MARTIN, Michael, B. , STEINMAN, Douglas, H. , SHEPPARD, George, S. , CARRERA, George, M., Jr.
IPC分类号： A61K31/44 , C07D513/04 , C07D498/04 , C07D487/04
CPC分类号： C07D487/04 , A61K49/06 , C07D213/69 , C07D513/04
摘要： Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazoline, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：EP0874808A1
公开(公告)日：1998-11-04
申请号：EP96940406.0
申请日：1996-11-13
申请人： Abbott Laboratories
发明人： FESIK, Stephen, W. , SUMMERS, James, B., Jr. , DAVIDSEN, Steven, K. , SHEPPARD, George, S. , STEINMAN, Douglas, H. , CARRERA, George, M., Jr. , FLORJANCIC, Alan , HOLMS, James, H.
CPC分类号： C07C323/60 , C07C259/06
摘要： Compounds of formula (I), or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNFα secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNFα secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNFα secretion.
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公开(公告)号：EP0595924A1
公开(公告)日：1994-05-11
申请号：EP92915895.0
申请日：1992-07-14
申请人： ABBOTT LABORATORIES
发明人： SUMMERS, James, B. , DAVIDSEN, Steven, K. , HOLMS, James, H. , PIREH, Daisy , HEYMAN, H., Robin , MARTIN, Michael, B. , STEINMAN, Douglas, H. , SHEPPARD, George, S. , CARRERA, George, M., Jr.
IPC分类号： A61K31 , A61K49 , A61P1 , A61P7 , A61P9 , A61P11 , A61P17 , A61P29 , A61P37 , A61P43 , C07B47 , C07D213 , C07D487 , C07D498 , C07D513 , C07F5 , C07F13
CPC分类号： C07D487/04 , A61K49/06 , C07D213/69 , C07D513/04
摘要： L'invention se rapporte à des composés d'indole substitués à la position 3 par un groupe de 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazoline, ou 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole qui sont des antagonistes puissants du facteur d'activation des plaquettes (PAF) et sont utiles dans le traitement des troubles relatifs au PAF et comprenant l'asthme, les états de choc, la détresse respiratoire, les inflammations aiguës, le rejet d'organes transplantés, l'ulcération gastro-intestinale, les allergies de la peau, l'immunité cellulaire tardive, la parturition, la maturation pulmonaire foetale et la différenciation cellulaire.
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公开(公告)号：EP1740579A1
公开(公告)日：2007-01-10
申请号：EP05742125.7
申请日：2005-03-24
发明人： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
摘要： Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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