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1.发明公开METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B 审中-公开方法的处理对维甲酸吸引力与CYP26A和CYP26B的选择性抑制剂疾病
公开(公告)号：EP1696899A1
公开(公告)日：2006-09-06
申请号：EP04814113.9
申请日：2004-12-13
申请人： ALLERGAN, INC.
发明人： VASUDEVAN, Jayasree , YANG, Rong , WANG, Liming , LIU, Xiaoxia , TSANG, Kwok, Yin , LI, Ling , TAKEUCHI, Janet, A. , VU, Thong , BEARD, Richard, L. , BHAT, Smita , CHANDRARATNA, Roshantha, A.
IPC分类号： A61K31/19 , A61K31/35 , A61K31/38 , A61K31/192
CPC分类号： A61K31/19 , A61K31/192 , A61K31/35 , A61K31/38
摘要： The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.
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2.发明授权OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF 有权恶唑烷OR 噻唑烷衍生物有关使用AS亚型选择性α-2肾上腺素受体激动剂，
公开(公告)号：EP2242753B1
公开(公告)日：2015-04-08
申请号：EP09703035.7
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D413/12 , C07D417/12 , A61K31/422 , A61K31/427 , A61P29/00
CPC分类号： C07D401/12 , A61K31/422 , A61K31/497 , C07D213/18 , C07D241/12 , C07D263/12 , C07D403/12 , C07D413/12 , C07D417/12
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3.发明公开BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS 审中-公开双甲基氨基甲酸酯衍生物1-磷脂酰肌醇
公开(公告)号：EP2696877A1
公开(公告)日：2014-02-19
申请号：EP12717536.2
申请日：2012-04-13
申请人： Allergan, Inc.
发明人： TAKEUCHI, Janet, A. , LI, Ling , IM, Wha, Bin
IPC分类号： A61K31/665 , C07D307/80 , C07D307/84 , C07D307/86 , C07F9/655 , A61K31/662 , A61P19/00 , A61P29/00 , C07F9/38
CPC分类号： A61K31/665 , A61K31/662 , C07D215/12 , C07F9/3808 , C07F9/3834 , C07F9/60 , C07F9/65517
摘要： The present invention relates to novel bicyclic methyl amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1 -phosphate receptors.
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4.发明公开
公开(公告)号：EP2265269A1
公开(公告)日：2010-12-29
申请号：EP09723978.4
申请日：2009-03-24
申请人： Allergan, Inc.
发明人： TAKEUCHI, Janet, A. , LI, Ling , HEIDELBAUGH, Todd, M. , CHOW, Ken , KEDZIE, Karen, M. , GIL, Daniel, W. , FANG, Wenkui, K.
IPC分类号： A61K31/4166 , A61K31/421 , A61K31/426 , A61P25/02 , A61P25/04 , A61P43/00 , A61K31/00
CPC分类号： A61K31/4164 , A61K31/421 , A61K31/426
摘要： The invention provides methods for treating pain in mammals. In particular, the invention provides well-defined aminoimidazolines, aminothiazolines, and aminooxazo lines and pharmaceutical compositions thereof to treat pain.
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5.发明公开
公开(公告)号：EP2240468A1
公开(公告)日：2010-10-20
申请号：EP09702233.9
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D233/48 , A61P25/00
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供了可用作亚型选择性α2肾上腺素能激动剂的定义明确的杂环化合物。 如此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节有关的多种病症。
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6.发明授权SUBSTITUTED 3-AMINO-1-OXO OR THIOXO-1,2,5,6,7,8-HEXAHYDRO-2,7-NAPHTHYRIDINE-4-CARBONITRILES AS SELECTIVE ALPHA 2B ANTAGONISTS 有权取代的3-氨基-1-氧代或硫代-1,2,5,6,7,8-六氢-2,7-萘啶-4-甲腈，为选择性拮抗剂ALPHA 2B
公开(公告)号：EP2334676B1
公开(公告)日：2016-07-06
申请号：EP09792255.3
申请日：2009-09-04
申请人： ALLERGAN, INC.
发明人： CAPPIELLO, John, R. , CHOW, Ken , HEIDELBAUGH, Todd, M. , TAKEUCHI, Janet, A. , GARST, Michael, E. , GIL, Daniel, W. , KEDZIE, Karen, M. , DONELLO, John, E.
IPC分类号： C07D471/04 , A61K31/4745 , A61P29/00
CPC分类号： C07D471/04
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7.发明授权
公开(公告)号：EP2249834B1
公开(公告)日：2015-05-13
申请号：EP09702616.5
申请日：2009-01-15
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： A61K31/4439 , A61K31/497 , A61P29/00
CPC分类号： A61K31/4439 , A61K31/497
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8.发明授权
公开(公告)号：EP2240468B1
公开(公告)日：2013-10-16
申请号：EP09702233.9
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D233/48 , A61P25/00
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP2643333A2
公开(公告)日：2013-10-02
申请号：EP11791689.0
申请日：2011-11-15
申请人： Allergan, Inc.
发明人： TAKEUCHI, Janet, A. , LI, Ling , CHOW, Ken , IM, Wha Bin
IPC分类号： C07F9/38 , A61K31/662 , A61K31/675
CPC分类号： C07F9/65318 , A61K31/662 , A61K31/675
摘要： The present invention relates to novel phosphonic acids derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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10.发明公开
公开(公告)号：EP2249834A1
公开(公告)日：2010-11-17
申请号：EP09702616.5
申请日：2009-01-15
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： A61K31/4439 , A61K31/497 , A61P29/00
CPC分类号： A61K31/4439 , A61K31/497
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
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