公开(公告)号：EP1370533A2

公开(公告)日：2003-12-17

申请号：EP02723489.7

申请日：2002-03-13

申请人： Allergan, Inc.

发明人： CHOW, Ken ,  GIL, Daniel, W. ,  BURKE, James, A. ,  HARCOURT, Dale, A. ,  GARST, Michael, E. ,  WHEELER, Larry, A. ,  MUNK, Stephen, A. ,  GOMEZ, Dario, G.

IPC分类号： C07D233/54 ,  A61K31/4164 ,  A61P43/00 ,  C07D405/06 ,  C07D409/06 ,  C07D401/06

CPC分类号： C07D233/56 ,  C07D233/06 ,  C07D233/10 ,  C07D233/64 ,  C07D233/84 ,  C07D263/28 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/12 ,  C07D495/04

摘要： A compound having a structure selected from the group consisting of: in which each x is independently (1) or (2); Y is selected from the group consisting of O;S;N;-(C(R7)z)s-where each R7 IS independently as previously defined fir R1, each z is independently 1-2, and s is 1-3;CH=; -CH=CH ;or Y1CH2_where Y1 is O, N, or S; and the dotted lines are optional double bonds, with the pviso that if the ring including Y is a cyclohexane ring or a heterocyclic 5 member ring said ring is not fully unsaturated, and that if Y is O,N or S, the ring including Y contains at least one said double bond, said compound further having selective agonist activity at the α2B or α2B/α2C adrenergic receptor subtype(s) over the α2A adrenergic receptor subtype, and all pharmacologically acceptable salts, esters, stereoisomers and racemic mixtures thereof.

公开(公告)号：EP2303264B1

公开(公告)日：2018-04-04

申请号：EP09763343.2

申请日：2009-06-05

申请人： ALLERGAN, INC.

发明人： FANG, Wenkui, K. ,  NGUYEN, Phong, X. ,  CHOW, Ken ,  HEIDELBAUGH, Todd, M. ,  GOMEZ, Dario, G. ,  GARST, Michael, E. ,  SINHA, Santosh, C. ,  Daniel W. Gil ,  John E. Donello

IPC分类号： A61K31/4168 ,  A61P9/12

CPC分类号： A61K31/4168

摘要： Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an ±-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.

公开(公告)号：EP2303264A1

公开(公告)日：2011-04-06

申请号：EP09763343.2

申请日：2009-06-05

申请人： Allergan, Inc.

发明人： FANG, Wenkui, K. ,  NGUYEN, Phong, X. ,  CHOW, Ken ,  HEIDELBAUGH, Todd, M. ,  GOMEZ, Dario, G. ,  GARST, Michael, E. ,  SINHA, Santosh, C.

IPC分类号： A61K31/4168 ,  A61P9/12

CPC分类号： A61K31/4168

摘要： Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an ±-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.

公开(公告)号：EP1370533B1

公开(公告)日：2015-05-06

申请号：EP02723489.7

申请日：2002-03-13

申请人： ALLERGAN, INC.

发明人： CHOW, Ken ,  GIL, Daniel, W. ,  BURKE, James, A. ,  HARCOURT, Dale, A. ,  GARST, Michael, E. ,  WHEELER, Larry, A. ,  MUNK, Stephen, A. ,  GOMEZ, Dario, G.

IPC分类号： C07D233/54 ,  A61K31/4164 ,  A61P43/00 ,  C07D405/06 ,  C07D409/06 ,  C07D401/06 ,  C07D233/06 ,  C07D233/10 ,  C07D233/56 ,  C07D233/64 ,  C07D233/84 ,  C07D403/06 ,  C07D413/12 ,  C07D263/28 ,  C07D495/04

CPC分类号： C07D233/56 ,  C07D233/06 ,  C07D233/10 ,  C07D233/64 ,  C07D233/84 ,  C07D263/28 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/12 ,  C07D495/04

公开(公告)号：EP2188261A1

公开(公告)日：2010-05-26

申请号：EP08797858.1

申请日：2008-08-14

申请人： ALLERGAN, INC.

发明人： CHOW, Ken ,  FANG, Wenkui, K. ,  CORPUZ, Evelyn, G. ,  GOMEZ, Dario, G. ,  SINHA, Santosh, C. ,  BHAT, Smita, S. ,  HEIDELBAUGH, Todd, M. ,  GIL, Daniel, W.

IPC分类号： C07D233/50 ,  C07D263/28 ,  C07D277/18 ,  A61K31/4168 ,  A61K31/421 ,  A61K31/426 ,  A61P25/04

CPC分类号： C07D233/50 ,  C07D263/28 ,  C07D277/18

摘要： Disclosed herein is a compound having a structure (I), compositions, methods, and medicaments related thereto are also disclosed.

公开(公告)号：EP1507767A1

公开(公告)日：2005-02-23

申请号：EP03738924.4

申请日：2003-05-16

申请人： Allergan, Inc.

发明人： CHOW, Ken ,  HEIDELBAUGH, Todd ,  GIL, Daniel ,  GARST, Michael ,  WHEELER, Larry, A. ,  NGUYEN, Phong, X. ,  GOMEZ, Dario, G.

IPC分类号： C07D233/84 ,  C07D233/70 ,  A61K31/4164 ,  A61K31/4166 ,  C07D409/06 ,  C07D401/06 ,  C07D405/06 ,  C07D409/08 ,  A61K31/4178

CPC分类号： C07D401/06 ,  C07D233/70 ,  C07D233/84 ,  C07D405/06 ,  C07D409/06 ,  C07D409/08

摘要： Compounds of Formula (I): where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula (I) are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula (I) where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.