公开(公告)号：EP1392264A1

公开(公告)日：2004-03-03

申请号：EP02771848.5

申请日：2002-05-17

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61K31/439

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1392261A2

公开(公告)日：2004-03-03

申请号：EP02739410.5

申请日：2002-05-23

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61K31/405

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1392258A2

公开(公告)日：2004-03-03

申请号：EP02737131.9

申请日：2002-05-22

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/192 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  F24V30/00 ,  Y10S514/958

摘要： The present invention relates to the delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route. Specifically, it relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of alprazolam, estazolam, midazolam or triazolam. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of alprazolam, estazolam, midazolam or triazolam, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of alprazolam, estazolam, midazolam or triazolam; and, b) a device that forms an alprazolam, estazolam, midazolam or triazolam containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1503744A1

公开(公告)日：2005-02-09

申请号：EP03734009.8

申请日：2003-05-13

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61M15/00

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61M11/001 ,  A61M11/041 ,  A61M15/00 ,  Y10S514/958

摘要： The present invention relates to the delivery of drug amines through an inhalation route. Specifically, it relates to aerosols containing drug amines that are used in inhalation therapy. In one aspect of the present invention, a method of delivering an amine drug in an aerosol form is provided. The method comprises: a) heating a coating, which includes an amine drug salt on a substrate contained in a device to a temperature sufficient to volatilize the amine drug from the coating, b) by said heating, forming an amine drug vapor, and c) during said heating, drawing air through said device, condensing said vapor to form aerosol particles containing less than 10% degradation products of the compound.

公开(公告)号：EP1392257A1

公开(公告)日：2004-03-03

申请号：EP02731930.0

申请日：2002-05-21

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61K31/4545

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1389096A1

公开(公告)日：2004-02-18

申请号：EP02731894.8

申请日：2002-05-21

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61K31/485

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1392259A2

公开(公告)日：2004-03-03

申请号：EP02737132.7

申请日：2002-05-22

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1389098A1

公开(公告)日：2004-02-18

申请号：EP02737053.5

申请日：2002-05-20

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61K31/551

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1389095A1

公开(公告)日：2004-02-18

申请号：EP02729255.6

申请日：2002-05-16

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61K31/4525 ,  A61K31/55 ,  A61K31/19

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.

公开(公告)号：EP1389094A1

公开(公告)日：2004-02-18

申请号：EP02729235.8

申请日：2002-05-17

申请人： Alexza Molecular Delivery Corporation

发明人： RABINOWITZ, Joshua, D. ,  ZAFFARONI, Alejandro, C.

IPC分类号： A61K9/72 ,  A61K31/437 ,  A61K31/519 ,  A61K31/4985

CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a sedative-hypnotic. In a method aspect of the present invention, a sedative-hypnotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a sedative-hypnotic; and, b) a device that forms a sedative-hypnotic containing aerosol from the composition, for inhalation by the mammal.