公开(公告)号：EP1827434B1

公开(公告)日：2014-01-15

申请号：EP05848812.3

申请日：2005-11-29

申请人： Amgen Inc.

发明人： KIM, Tae-seong ,  BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  DOMINGUEZ, Celia ,  FELLOWS, Ingrid ,  LEE, Matthew ,  LIU, Longbin ,  RAINBEAU, Elizabeth ,  SIEGMUND, Aaron, C. ,  TASKER, Andrew ,  XI, Ning ,  CHENG, Yuan

IPC分类号： A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D215/233 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

公开(公告)号：EP2231661A1

公开(公告)日：2010-09-29

申请号：EP08867948.5

申请日：2008-12-18

申请人： Amgen, Inc.

发明人： BOOKER, Shon ,  KIM, Tae-seong ,  LIAO, Hongyu ,  LIU, Longbin ,  NORMAN, Mark H. ,  PETERSON, Emily Anne ,  STEC, Markian ,  TAMAYO, Nuria A.

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/4162 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase; Formula (I) methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds.

公开(公告)号：EP2183232A2

公开(公告)日：2010-05-12

申请号：EP08794970.7

申请日：2008-08-01

申请人： Amgen, Inc

发明人： BOOKER, Shon ,  D'ANGELO, Noel ,  D'AMICO, Derin C. ,  KIM, Tae-seong ,  LIU, Longbin ,  MEAGHER, Kristin ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie B. ,  SMITH, Adrian L. ,  TAMAYO, Nuria A. ,  WHITTINGTON, Douglas A. ,  XI, Ning ,  YANG, Kevin

IPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  A61K31/423 ,  A61K31/424 ,  A61K31/428 ,  A61K31/429 ,  A61P35/00

CPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04

摘要： The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

公开(公告)号：EP1713484A2

公开(公告)日：2006-10-25

申请号：EP05722533.6

申请日：2005-01-24

申请人： AMGEN INC.

发明人： POTASHMAN, Michele ,  KIM, Tae-seong ,  BELLON, Steven ,  BOOKER, Shon ,  CHENG, Yuan ,  KIM, Joseph, L. ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  HARMANGE, Jean-Christophe ,  BORG, George ,  WEISS, Matthew ,  HODOUS, Brian, L. ,  GRACEFFA, Russell ,  BUCKNER, Willianm, H. ,  MASSE, Craig, E. ,  CHOQUETTE, Deborah ,  MARTIN, Matthew, W. ,  GERMAIN, Julie ,  CHAFFEE, Stuart, C. ,  NUNES, Joseph, J. ,  PATEL, Vinod, F. ,  BUCHANAN, John L. ,  DIPIETRO, Lucian V. ,  HABGOOD; Gregory J. ,  McGOWAN; David C. ,  WHITTINGTON, Douglas A. ,  LA, Daniel

IPC分类号： A61K31/505

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutically compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP2183232B1

公开(公告)日：2013-03-06

申请号：EP08794970.7

申请日：2008-08-01

申请人： Amgen, Inc

发明人： BOOKER, Shon ,  D'ANGELO, Noel ,  D'AMICO, Derin C. ,  KIM, Tae-seong ,  LIU, Longbin ,  MEAGHER, Kristin ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie B. ,  SMITH, Adrian L. ,  TAMAYO, Nuria A. ,  WHITTINGTON, Douglas A. ,  XI, Ning ,  YANG, Kevin

IPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  A61K31/423 ,  A61K31/424 ,  A61K31/428 ,  A61K31/429 ,  A61P35/00

CPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04

公开(公告)号：EP2118069A2

公开(公告)日：2009-11-18

申请号：EP08724464.6

申请日：2008-01-09

申请人： Amgen Inc.

发明人： BOOKER, Shon ,  D'ANGELO, Noel ,  GERMAIN, Julie ,  HARMANGE, Jean-christophe ,  KIM, Tae-seong ,  POTASHMAN, Michele

IPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K31/416 ,  A61K31/4725 ,  A61K31/5025 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D231/22 ,  C07D231/56 ,  C07D401/12 ,  C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1827434A2

公开(公告)日：2007-09-05

申请号：EP05848812.3

申请日：2005-11-29

申请人： Amgen Inc.

发明人： KIM, Tae-seong ,  BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  DOMINGUEZ, Celia ,  FELLOWS, Ingrid ,  LEE, Matthew ,  LIU, Longbin ,  RAINBEAU, Elizabeth ,  SIEGMUND, Aaron, C. ,  TASKER, Andrew ,  XI, Ning ,  CHENG, Yuan

IPC分类号： A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D215/233 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

摘要： Selected compounds of Formula (I) are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases such as cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. R - X - W - A - Y - R Formula (I) wherein R is X is O, S, NR2 or CR3R4 W is an substituted or unsubstituted aryl or substituted or unsubstituted 5- or 6- membered heteroaryl.

公开(公告)号：EP2118069B1

公开(公告)日：2014-01-01

申请号：EP08724464.6

申请日：2008-01-09

申请人： Amgen Inc.

发明人： BOOKER, Shon ,  D'ANGELO, Noel ,  GERMAIN, Julie ,  HARMANGE, Jean-christophe ,  KIM, Tae-seong ,  POTASHMAN, Michele

IPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K31/416 ,  A61K31/4725 ,  A61K31/5025 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D231/22 ,  C07D231/56 ,  C07D401/12 ,  C07D471/04

公开(公告)号：EP2231663A2

公开(公告)日：2010-09-29

申请号：EP08870985.2

申请日：2008-10-14

申请人： Amgen, Inc

发明人： ALBRECHT, Brian K. ,  BAUER, David ,  BELLON, Steven ,  BODE, Christiane M. ,  BOOKER, Shon ,  BOEZIO, Alessandro ,  CHOQUETTE, Deborah ,  D'AMICO, Derin ,  HARMANGE, Jean-christophe ,  HIRAI, Satoko ,  HUNGATE, Randall W. ,  KIM, Tae-seong ,  LEWIS, Richard T. ,  LIU, Longbin ,  LOHMAN, Julia ,  NORMAN, Mark H. ,  POTASHMAN, Michelle ,  SIEGMUND, Aaron C. ,  SPRINGER, Stephanie ,  STEC, Markian ,  XI, Ning ,  YANG, Kevin ,  PETERSON, Emily, A. ,  ROMERO, Karina ,  COPELAND, Katrina, W.

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  A61K31/4355

CPC分类号： A61K31/538 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选定的化合物对于预防和治疗疾病如HGF介导的疾病是有效的。 本发明包括新化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及癌症等的疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。