公开(公告)号：EP2609081A1

公开(公告)日：2013-07-03

申请号：EP11752398.5

申请日：2011-08-22

申请人： Amgen Inc.

发明人： ASHTON, Kate ,  BARTBERGER, Michael David ,  BO, Yunxin ,  BRYAN, Marian C. ,  CROGHAN, Michael ,  FOTSCH, Christopher Harold ,  HALE, Clarence Henderson ,  KUNZ, Roxanne Kay ,  LIU, Longbin ,  NISHIMURA, Nobuko ,  NORMAN, Mark H. ,  PENNINGTON, Lewis Dale ,  POON, Steve Fong ,  STEC, Markian Myroslaw ,  ST. JEAN, David, Joseph, Jr. ,  TAMAYO, Nuria A. ,  TEGLEY, Christopher Michael ,  YANG, Kevin Chao

IPC分类号： C07D213/30 ,  C07D213/71 ,  C07D213/74 ,  C07D231/18 ,  C07D239/42 ,  C07D241/04 ,  C07D277/36 ,  C07D333/34 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D491/08 ,  C07D498/08

CPC分类号： C07D333/34 ,  C07C317/22 ,  C07D213/30 ,  C07D213/32 ,  C07D213/71 ,  C07D213/72 ,  C07D213/74 ,  C07D231/18 ,  C07D239/42 ,  C07D241/04 ,  C07D277/36 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D498/08

摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

公开(公告)号：EP1794135A1

公开(公告)日：2007-06-13

申请号：EP05802134.6

申请日：2005-09-27

申请人： Amgen Inc.

发明人： ANDERSEN, Denise, Lyn ,  CHANG, Catherine, H. ,  FALSEY, James, R. ,  FROHN, Michael, J. ,  HONG, Fang-Tsao ,  LIAO, Hongyu ,  LIU, Longbin ,  LOPEZ, Patricia ,  RETZ, Daniel, Martin ,  RISHTON, Gilbert, M. ,  RZASA, Robert, M. ,  SIEGMUND, Aaron, C. ,  TADESSE, Seifu ,  TAMAYO, Nuria ,  TEGLEY, Christopher, M.

IPC分类号： C07D239/48 ,  A61K31/506 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to pyridines, pyrimidines and derivatives thereof, (I) or a pharmaceutically acceptable salts thereof, wherein X1 is N or CR3; X2 is N or CR4; or -X1=X2- is -C(=O)-N(Ra)- or -N(Ra)-C(=O)-; X3 is N or CR4; X4 is N or CR4; X5 is N or CR6; X6 is N or CR6; wherein only 1, 2 or 3 of X1, X2, X3 and X4 are N; R1 is a saturated partially saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring is substituted by 0, 1, 2 or 3 substituents. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

公开(公告)号：EP1716150A2

公开(公告)日：2006-11-02

申请号：EP05711810.1

申请日：2005-01-21

申请人： AMGEN INC.

发明人： FROHN, Michael, J. ,  HONG, Fang-Tsao ,  LIU, Longbin ,  LOPEZ, Patricia ,  SIEGMUND, Aaron, C. ,  TADESSE, Seifu ,  TAMAYO, Nuria

IPC分类号： C07D487/04 ,  A61K31/506 ,  A61K31/513

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention relates to pyrimidinones and pyridones and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

公开(公告)号：EP3630761A1

公开(公告)日：2020-04-08

申请号：EP18731624.5

申请日：2018-05-21

申请人： Amgen Inc.

发明人： LANMAN, Brian Alan ,  CHEN, Jian ,  REED, Anthony B. ,  CEE, Victor J. ,  LIU, Longbin ,  KOPECKY, David John ,  LOPEZ, Patricia ,  WURZ, Ryan Paul ,  NGUYEN, Thomas T. ,  BOOKER, Shon ,  NISHIMURA, Nobuko ,  SHIN, Youngsook ,  TAMAYO, Nuria A. ,  ALLEN, John Gordon ,  ALLEN, Jennifer Rebecca

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00 ,  C07D475/00

公开(公告)号：EP2424859B1

公开(公告)日：2015-04-08

申请号：EP10718364.2

申请日：2010-04-27

申请人： Amgen, Inc

发明人： ANDREWS, Kristin ,  BO, Yunxin, Y. ,  BOOKER, Shon ,  CEE, Victor, J. ,  D'ANGELO, Noel ,  HERBERICH, Bradley, J. ,  HONG, Fang-Tsao ,  JACKSON, Claire, L., M. ,  LANMAN, Brian, A. ,  LIAO, Hongyu ,  LIU, Longbin ,  NISHIMURA, Nobuko ,  NORMAN, Mark, H. ,  PETTUS, Liping, H. ,  REED, Anthony, B. ,  SMITH, Adrian, L. ,  TADESSE, Seifu ,  TAMAYO, Nuria, A. ,  WU, Bin ,  WURZ, Ryan ,  YANG, Kevin

IPC分类号： C07D401/14 ,  C07D473/00 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：EP2307400B1

公开(公告)日：2014-04-23

申请号：EP09767432.9

申请日：2009-05-29

申请人： Amgen, Inc

发明人： BO, Yunxin Y. ,  BOOKER, Shon ,  BRYAN, Marian ,  DEAK, Holly L. ,  LIU, Longbin ,  ANDREWS, Kristin ,  NISHIMURA, Nobuko ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie ,  SIEGMUND, Aaron C. ,  TAMAYO, Nuria A. ,  YANG, Kevin

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/498 ,  A61K31/502 ,  A61K31/4709 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04

公开(公告)号：EP2183232B1

公开(公告)日：2013-03-06

申请号：EP08794970.7

申请日：2008-08-01

申请人： Amgen, Inc

发明人： BOOKER, Shon ,  D'ANGELO, Noel ,  D'AMICO, Derin C. ,  KIM, Tae-seong ,  LIU, Longbin ,  MEAGHER, Kristin ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie B. ,  SMITH, Adrian L. ,  TAMAYO, Nuria A. ,  WHITTINGTON, Douglas A. ,  XI, Ning ,  YANG, Kevin

IPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  A61K31/423 ,  A61K31/424 ,  A61K31/428 ,  A61K31/429 ,  A61P35/00

CPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04

公开(公告)号：EP1827434A2

公开(公告)日：2007-09-05

申请号：EP05848812.3

申请日：2005-11-29

申请人： Amgen Inc.

发明人： KIM, Tae-seong ,  BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  DOMINGUEZ, Celia ,  FELLOWS, Ingrid ,  LEE, Matthew ,  LIU, Longbin ,  RAINBEAU, Elizabeth ,  SIEGMUND, Aaron, C. ,  TASKER, Andrew ,  XI, Ning ,  CHENG, Yuan

IPC分类号： A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D215/233 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

摘要： Selected compounds of Formula (I) are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases such as cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. R - X - W - A - Y - R Formula (I) wherein R is X is O, S, NR2 or CR3R4 W is an substituted or unsubstituted aryl or substituted or unsubstituted 5- or 6- membered heteroaryl.

公开(公告)号：EP3807276A2

公开(公告)日：2021-04-21

申请号：EP19858308.0

申请日：2019-06-11

申请人： Amgen Inc.

发明人： ALLEN, John Gordon ,  LANMAN, Brian Alan ,  CHEN, Jian ,  REED, Anthony B. ,  CEE, Victor J. ,  LIU, Longbin ,  LOPEZ, Patricia ,  WURZ, Ryan Paul ,  NGUYEN, Thomas T. ,  BOOKER, Shon ,  ALLEN, Jennifer Rebecca ,  CHU-MOYER, Margaret ,  AMEGADZIE, Albert ,  CHEN, Ning ,  GOODMAN, Clifford ,  LOW, Jonathan D. ,  MA, Vu Van ,  MINATTI, Ana Elena ,  NISHIMURA, Nobuko ,  PICKRELL, Alexander J. ,  WANG, Hui-Ling ,  SHIN, Youngsook ,  SIEGMUND, Aaron C. ,  YANG, Kevin C. ,  TAMAYO, Nuria A. ,  WALTON, Mary ,  XUE, Qiufen

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61P35/00 ,  A61K45/06

公开(公告)号：EP3788038A1

公开(公告)日：2021-03-10

申请号：EP19731372.9

申请日：2019-05-03

申请人： Amgen Inc.

发明人： ALLEN, John Gordon ,  ALLEN, Jennifer Rebecca ,  MINATTI, Ana Elena ,  XUE, Qiufen ,  WURZ, Ryan Paul ,  TEGLEY, Christopher M. ,  PICKRELL, Alexander J. ,  NGUYEN, Thomas T. ,  MA, Vu Van ,  LOPEZ, Patricia ,  LIU, Longbin ,  KOPECKY, David John ,  FROHN, Michael J. ,  CHEN, Ning ,  CHEN, Jian Jeffrey ,  SIEGMUND, Aaron C. ,  AMEGADZIE, Albert ,  TAMAYO, Nuria A. ,  BOOKER, Shon ,  GOODMAN, Clifford ,  WALTON, Mary ,  NISHIMURA, Nobuko ,  SHIN, Youngsook ,  LOW, Jonathan D. ,  CEE, Victor J. ,  REED, Anthony B. ,  WANG, Hui-Ling ,  LANMAN, Brian Alan

IPC分类号： C07D403/04 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  A61P35/00 ,  A61K31/519