公开(公告)号：EP1444338A2

公开(公告)日：2004-08-11

申请号：EP02789697.6

申请日：2002-11-15

申请人： Arryx, Inc.

发明人： GRUBER, Lewis ,  MUETH, Dan

IPC分类号： C12N13/00 ,  C12M1/36 ,  C12M1/34 ,  G02B21/34

CPC分类号： B01L3/502761 ,  B01L3/502746 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0418 ,  B01L2400/0454 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/086

摘要： A sample chip (10) includes a body portion (16); and a cover portion (14) disposed on the body portion (16); wherein an upper surface (20) of the body portion (16) includes a plurality of microchannels (12) in which objects are introduced for examination and manipulation by optical traps. In one embodiment, at least one of the microchannels (12) includes a barrier (62) which holds the objects so that they can be held and manipulated by the optical traps. In another embodiment, at least one of the microchannels (12) includes a sample chamber (50) at which the barrier (62) is disposed. The number of microchannels (12) and their configuration can vary, and the microchannels (12) may intersect, the sample chamber (50) being disposed at the intersection. The barrier (93) includes at least one of a plurality of barrier structures (101) which are integrally formed or removably disposed in the sample chamber (50). The barrier structures (101) can take different shapes and can be in any combination of shapes.

公开(公告)号：EP1687663A2

公开(公告)日：2006-08-09

申请号：EP04817812.3

申请日：2004-10-28

申请人： Arryx, Inc.

发明人： PLEWA, Joseph ,  TANNER, Evan ,  MUETH, Dan ,  GRUBER, Lewis ,  BRADLEY, Kenneth

IPC分类号： G02B5/32 ,  G03H1/22 ,  G03H1/08

CPC分类号： G03H1/22 ,  G02B5/32 ,  G03H1/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/2284

摘要： A method for trapping particles where a characteristic of a particle is selected, a laser is used to generate a holographic optical trap, and the beams are modulated and focused as desired.

公开(公告)号：EP1663460A2

公开(公告)日：2006-06-07

申请号：EP04783338.9

申请日：2004-09-03

申请人： Arryx, Inc.

发明人： Rosenbaum, Neil, Harris ,  ANDERSON, Amy ,  GRUBER, Lewis ,  MUETH, Dan ,  PLEWA, Joseph ,  SHIREMAN, Jessica

IPC分类号： B01D61/00

CPC分类号： A61M1/36 ,  A61M1/38 ,  B03C1/28 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/18 ,  G01N30/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  H05H3/04

摘要： An apparatus (100) for separating a plurality of components (A, B, C, E) in a fluid includes an optically transparent sorting channel (110) having a first inlet (120) for a first flow (W) and a second inlet (120) for a second flow (X), and a first outlet (130) for the first flow (W) and a second outlet (130) for the second flow (X); and a holographic optical trap system (210) coupled to the optically transparent sorting channel (200) for selectively moving a first component (A) of the plurality of components (A, B, C, E) in the first flow (W) into the second flow (X) to form an enriched second flow (X).

公开(公告)号：EP1438182A1

公开(公告)日：2004-07-21

申请号：EP02796453.5

申请日：2002-09-03

申请人： Arryx, Inc.

发明人： GRUBER, Lewis ,  BRADLEY, Kenneth

IPC分类号： B29D11/00 ,  H05H3/04

CPC分类号： B82Y20/00 ,  B82Y10/00 ,  B82Y30/00 ,  G02B21/32

摘要： Micrometer and nanometer-sized tools (69), refered to as MOTS an d NOTS, respectively, are manipulated in the illumination (71) of an optical trap (70) and are able to alter the physical, chemical or electronic structure or orientation of a workpiece (68).

公开(公告)号：EP1573641A3

公开(公告)日：2005-12-07

申请号：EP03772098.4

申请日：2003-07-31

申请人： Arryx, Inc.

发明人： GRUBER, Lewis ,  BRADLEY, Kenneth ,  LOPES, Ward ,  LANCELOT, Robert, W. ,  PLEWA, Joseph, S. ,  GRIER, David

IPC分类号： G06K1/00

公开(公告)号：EP1573641A2

公开(公告)日：2005-09-14

申请号：EP03772098.4

申请日：2003-07-31

申请人： Arryx, Inc.

发明人： GRUBER, Lewis ,  BRADLEY, Kenneth ,  LOPES, Ward ,  LANCELOT, Robert, W. ,  PLEWA, Joseph, S. ,  GRIER, David

IPC分类号： G06K1/00

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N2015/149 ,  G02B21/32 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  G03H2225/32 ,  H05H3/04

摘要： A system (200) for sorting objects (305, 306) includes the objects (305, 306) introduced into a channel (203) and a beam steering apparatus (505) for evaluating and sorting the objects (305, 306) which meet a predetermined criteria from objects (305, 306) which do not meet the criteria.

摘要翻译： 本发明采用的光束转向装置暴晒从其他细胞，组织，和污染物有价值的细胞（306）。 在一个中，系统平衡实施方式的光俘获逆着流动并行细胞计算机程序定向陷阱（305）进行差分处理基于其组合物或标签直接分离单元的柔性控制下的排序。

公开(公告)号：EP1573641B1

公开(公告)日：2013-06-26

申请号：EP03772098.4

申请日：2003-07-31

申请人： Arryx, Inc.

发明人： GRUBER, Lewis ,  BRADLEY, Kenneth ,  LOPES, Ward ,  LANCELOT, Robert, W. ,  PLEWA, Joseph, S. ,  GRIER, David

IPC分类号： G21K1/00 ,  G01N30/00

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N2015/149 ,  G02B21/32 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  G03H2225/32 ,  H05H3/04

公开(公告)号：EP1549954B1

公开(公告)日：2008-11-26

申请号：EP03733937.1

申请日：2003-05-05

申请人： Arryx, Inc.

发明人： GRIER, David, G. ,  GRUBER, Lewis

IPC分类号： G01N33/543

CPC分类号： G01N33/54313 ,  G01N21/4788 ,  G01N21/7703 ,  G01N21/7743 ,  G01N33/5436 ,  G03H2001/0044 ,  G03H2001/0077 ,  Y10T428/2991

摘要： The present invention relates to a sensor for detecting chemical, biological, biochemical or other environmental stimuli, and includes a plurality of colloidal particles having chemical receptors bound to each particle's surface, wherein when a target stimulus is directed to the bound chemical receptor, the gelled matrix contracts or expands, which changes the lattice constant, thereby changing the pattern of diffracted light in a measurable manner so that the target stimulus' presence can be detected by a spectrometer. The plurality of colloidal particles are composed of a material having a first dielectric constant, and the gel and surrounding medium have a second dielectric constant. The colloidal particles can be assembled using holographic optical tweezers and polymerized to create an integrated sensor array, which diffracts light in a detectable characteristic manner.

公开(公告)号：EP1745530A2

公开(公告)日：2007-01-24

申请号：EP05728700.5

申请日：2005-03-17

申请人： Arryx, Inc.

发明人： PLEWA, Joseph ,  TANNER, Evan ,  MUETH, Dan ,  GRUBER, Lewis ,  BRADLEY, Kenneth

IPC分类号： H01S1/00 ,  H05H3/02 ,  H01S3/00 ,  G02B5/18 ,  G02B26/00 ,  G02B27/44

CPC分类号： B82Y20/00 ,  B82Y10/00 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2225/32

摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.

公开(公告)号：EP1549954A2

公开(公告)日：2005-07-06

申请号：EP03733937.1

申请日：2003-05-05

申请人： Arryx, Inc.

发明人： GRIER, David, G. ,  GRUBER, Lewis

IPC分类号： G01N33/543

CPC分类号： G01N33/54313 ,  G01N21/4788 ,  G01N21/7703 ,  G01N21/7743 ,  G01N33/5436 ,  G03H2001/0044 ,  G03H2001/0077 ,  Y10T428/2991

摘要： The present invention relates to a sensor for detecting chemical, biological, biochemical or other environmental stimuli, and includes a plurality of colloidal particles having chemical receptors bound to each particle's surface, wherein when a target stimulus is directed to the bound chemical receptor, the gelled matrix contracts or expands, which changes the lattice constant, thereby changing the pattern of diffracted light in a measurable manner so that the target stimulus' presence can be detected by a spectrometer. The plurality of colloidal particles are composed of a material having a first dielectric constant, and the gel and surrounding medium have a second dielectric constant. The colloidal particles can be assembled using holographic optical tweezers and polymerized to create an integrated sensor array, which diffracts light in a detectable characteristic manner.