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1.发明公开IMMUNOGENIC POLYPEPTIDES ENCODED BY MAGE MINIGENES AND USES THEREOF 有权BY GENE MAGE MINI CODED免疫多肽和用途
公开(公告)号：EP1282702A2
公开(公告)日：2003-02-12
申请号：EP01931269.3
申请日：2001-05-07
发明人： BERINSTEIN, Neil , TARTAGLIA, Jim , TINE, John, A. , MOINGEON, Philippe , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C12N15/12 , C07K14/47 , A61K39/00 , A61K38/17 , C12N15/863 , C12N15/861 , A61K31/7088 , A61K48/00
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
摘要： The invention discloses immunogenic polypeptides comprising several MAGE-specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.
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2.发明授权IMMUNOGENIC POLYPEPTIDES ENCODED BY MAGE MINIGENES AND USES THEREOF 有权BY GENE MAGE MINI CODED免疫多肽和用途
公开(公告)号：EP1282702B1
公开(公告)日：2006-11-29
申请号：EP01931269.3
申请日：2001-05-07
发明人： BERINSTEIN, Neil , TARTAGLIA, Jim , TINE, John, A. , MOINGEON, Philippe , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C12N15/12 , C07K14/47 , A61K39/00 , A61K38/17 , C12N15/863 , C12N15/861 , A61K31/7088 , A61K48/00
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
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公开(公告)号：EP1228095A1
公开(公告)日：2002-08-07
申请号：EP00971185.4
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： A gp100 molecule useful in modulating the immune system is described. In particular what is described is a nucleotide sequence for a gp100 which has been modified so as to be useful in modulating the immune system. The isolated nucleic acid sequence is described and referred to as gp100M. The corresponding protein, referred to as gp100M, is also described. Applications of the molecules as vaccines are described.
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公开(公告)号：EP1305414A2
公开(公告)日：2003-05-02
申请号：EP01956237.0
申请日：2001-07-27
发明人： BERINSTEIN, Neil , TARTAGLIA, James , TINE, John, A. , PANICALI, Dennis, L. , GRITZ, Linda , SCHLOM, Jeffrey
CPC分类号： A61K38/1709 , A61K39/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , A61K2039/53 , C07K14/70503
摘要： The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.
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5.发明公开
公开(公告)号：EP1227837A1
公开(公告)日：2002-08-07
申请号：EP00971184.7
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
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6.发明授权
公开(公告)号：EP1227837B1
公开(公告)日：2008-05-21
申请号：EP00971184.7
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
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公开(公告)号：EP1556082A1
公开(公告)日：2005-07-27
申请号：EP03769119.3
申请日：2003-10-21
发明人： ASTASTUROV, Igor , PETRELLA, Teresa , BAGRIACIK, Umit , DE BENEDETTE, Mark , BERINSTEIN, Neil , SPANER, David
CPC分类号： A61K39/0011 , A61K38/212 , A61K2039/55522
摘要： The present invention relates to the field of cancer immunotherapy. In particular, vaccines are administered in conjunction with high doses of cytokines to enhance an anti-tumor immune response.
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