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1.发明授权IMMUNOGENIC POLYPEPTIDES ENCODED BY MAGE MINIGENES AND USES THEREOF 有权BY GENE MAGE MINI CODED免疫多肽和用途
公开(公告)号：EP1282702B1
公开(公告)日：2006-11-29
申请号：EP01931269.3
申请日：2001-05-07
发明人： BERINSTEIN, Neil , TARTAGLIA, Jim , TINE, John, A. , MOINGEON, Philippe , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C12N15/12 , C07K14/47 , A61K39/00 , A61K38/17 , C12N15/863 , C12N15/861 , A61K31/7088 , A61K48/00
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
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公开(公告)号：EP2140247B1
公开(公告)日：2012-06-27
申请号：EP08726331.5
申请日：2008-03-03
CPC分类号： A61K31/7016 , A61K31/4745 , A61K45/06 , A61K2039/5158 , C07K14/7051 , C07K14/70517 , C12N5/0636 , C12N2500/22 , C12N2500/34 , C12N2501/59 , C12N2501/73 , G01N33/505 , A61K2300/00
摘要： The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from each other on T lymphocyte surfaces. Via use of modulators which change the distance between these receptors, the activity of the T lymphocyte is modulated.
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公开(公告)号：EP1119623B1
公开(公告)日：2009-04-01
申请号：EP99970121.2
申请日：1999-09-15
发明人： CHAUX, Pascal , STROOBANT, Vincent , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin, S. , VAN SNICK, Jacques , LETHE, Bernard , THIELEMANS, Kris , CORTHALS, Jurgen , HEIRMAN, Carlo
IPC分类号： C12N15/12 , C07K14/47 , G01N33/574 , C07K16/30 , C12N5/06
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4 T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A3 gene.
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4.发明授权
公开(公告)号：EP0789591B1
公开(公告)日：2003-04-16
申请号：EP95913476.8
申请日：1995-01-26
发明人： VAN DER BRUGGEN, Pierre , SZIKORA, Jean-Pierre , COULIE, Pierre , WILDMANN, Claude , BOEL, Pascale , BOON-FALLEUR, Thierry
IPC分类号： C12N15/12 , A61K48/00 , C12Q1/68 , C07K7/06 , C07K14/705
CPC分类号： G01N33/5011 , A61K35/17 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/70539 , G01N2333/70539 , G01N2800/52
摘要： This invention relates to MAGE-1 derived nonapeptides. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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公开(公告)号：EP1117679A2
公开(公告)日：2001-07-25
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
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公开(公告)号：EP1012283A1
公开(公告)日：2000-06-28
申请号：EP98945923.5
申请日：1998-09-04
发明人： THIELEMANS, Kris , HEIRMAN, Carlo , CORTHALS, Jurgen , CHAUX, Pascal , STROOBANT, Vincent , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , LUITEN, Rosalie
IPC分类号： C12N15/12 , C07K14/705 , C07K19/00 , G01N33/53 , G01N33/68 , A61K38/17 , A61K35/26 , C07K16/30 , C12N5/08
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products are also provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
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7.发明公开ISOLATED NUCLEIC ACID MOLECULE CODING FOR TUMOR REJECTION ANTIGEN PRECURSORS MAGE-C1 AND MAGE-C2 AND USES THEREOF 失效包含抗原前体MAGE TUMORABSTOSSUNGS-C1和MAGE-C2及其用途编码的分离的核酸分子
公开(公告)号：EP0979235A1
公开(公告)日：2000-02-16
申请号：EP98918810.7
申请日：1998-04-24
IPC分类号： C07H21/04 , A61K38/00 , A61K39/00 , A61K39/12 , G01N33/574 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which may be recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
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8.发明公开ISOLATED NUCLEIC ACID MOLECULE WHICH ENCODES MURINE TUMOR REJECTION ANTIGEN PRECURSOR SMAGE-3 失效分离的核酸分子，所述MAUSTUMORALSTOSSUNGS抗原前体Småge-3 CODE
公开(公告)号：EP0873350A1
公开(公告)日：1998-10-28
申请号：EP96921675.0
申请日：1996-06-18
CPC分类号： C07K14/4748
摘要： The invention relates to Smage-3, which is a nucleic acid molecule encoding a murine tumor rejection antigen precursor, which molecule differs from the previously described Smage nucleic acid molecules in that it is autosomal in nature.
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9.发明公开ISOLATED NUCLEIC ACID MOLECULE CODING FOR TUMOR REJECTION ANTIGEN PRECURSOR DAGE AND USES THEREOF 失效分离的核酸分子FOR THE TUMORABSTOSSUNGS抗原前体DAGE CODES和需求
公开(公告)号：EP0783511A1
公开(公告)日：1997-07-16
申请号：EP95934504.0
申请日：1995-09-21
IPC分类号： C12N15 , A61K35 , A61K38 , A61K39 , A61K48 , A61P35 , A61P37 , C07K7 , C07K14 , C12N5 , C12Q1
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
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10.发明公开MONOCLONAL ANBIBODIES WHICH BIND TO TUMOR REJECTION ANTIGEN PRECURSOR MAGE-1, RECOMBINANT MAGE-1, AND MAGE-1 DERIVED IMMUNOGENIC PEPTIDES 失效单克隆抗体在预DES TUMORABSTOSSANTIGEN MAGE-1参与结合的，重组的MAGE-1，MAGE-1和ABGEBIETETEIMMUNOGENE PEPTIDE
公开(公告)号：EP0752876A1
公开(公告)日：1997-01-15
申请号：EP95907978.0
申请日：1995-01-05
发明人： CHEN, Yao-Tseng , STOCKERT, Elisabeth , CHEN, Yachi , GARIN-CHESA, Pilar , RETTIG, Wolfgang J. , VAN DER BRUGGEN, Pierre , BOON-FALLEUR, Thierry , OLD, Lloyd J.
IPC分类号： C07K , C12N15 , A61K38 , A61K39 , A61P35 , C07H21 , C07K7 , C07K14 , C07K16 , C12N5 , C12P21 , G01N33 , C12R1
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.
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