公开(公告)号：EP0889969B1

公开(公告)日：2005-11-09

申请号：EP97914375.7

申请日：1997-03-12

申请人： Aventis Pharma S.A. ,  LUDWIG INSTITUTE FOR CANCER RESEARCH

发明人： BOON, Falleur ,  DUFFOUR, Marie-Thérèse ,  HADDADA, Hedi ,  LURQUIN, Christophe ,  PERRICAUDET, Michel ,  UYTTENHOVEGHESQUIERE, Catherine ,  WARNIER, Guy

IPC分类号： C12N15/86 ,  C07K14/705 ,  A61K48/00 ,  C12N5/10 ,  A61K39/00 ,  C12N15/12

CPC分类号： C07K14/4748 ,  A61K48/00 ,  A61K2039/51 ,  C12N2799/022

公开(公告)号：EP0889969A1

公开(公告)日：1999-01-13

申请号：EP97914375.0

申请日：1997-03-12

申请人： RHONE-POULENC RORER S.A. ,  LUDWIG INSTITUTE FOR CANCER RESEARCH

发明人： BOON, Falleur ,  DUFFOUR, Marie-Thérèse ,  HADDADA, Hedi ,  LURQUIN, Christophe ,  PERRICAUDET, Michel ,  UYTTENHOVEGHESQUIERE, Catherine ,  WARNIER, Guy

IPC分类号： C12N15 ,  A61K31 ,  A61K35 ,  A61K39 ,  A61K48 ,  A61P35 ,  C07K14 ,  C12N7

CPC分类号： C07K14/4748 ,  A61K48/00 ,  A61K2039/51 ,  C12N2799/022

摘要： A method for treating human tumours by gene therapy is disclosed. In particular, defective recombinant viruses with a sequence coding for a human tumour-specific antigen, and the use thereof for treating or preventing human tumours, as well as producing specific cytotoxic T-cells (CTLs) in vitro or ex vivo, are disclosed. Pharmaceutical compositions comprising said viruses, particularly in injectable form, are also disclosed.

公开(公告)号：EP0695360B1

公开(公告)日：2006-07-05

申请号：EP94913649.3

申请日：1994-04-15

申请人： Aventis Pharma S.A.

发明人： PERRICAUDET, Michel ,  HADDADA, Hedi ,  MAY, Evelyne

IPC分类号： C12N15/86 ,  A61K48/00 ,  C12N15/12 ,  C12N15/11

CPC分类号： C07K14/82 ,  A61K35/761 ,  A61K38/1758 ,  A61K48/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2710/10243 ,  C12N2710/10332 ,  C12N2710/10343 ,  A61K2300/00

摘要： Recombinant adenoviruses comprising a heterologous DNA sequence, preparation thereof, and use thereof for the treatment and/or prevention of cancer.

公开(公告)号：EP0698108B1

公开(公告)日：2001-11-28

申请号：EP94916259.8

申请日：1994-05-06

申请人： Aventis Pharma S.A.

发明人： HADDADA, Hedi ,  KLONJKOWSKI, Bernard ,  PERRICAUDET, Michel ,  VIGNE, Emmanuelle

IPC分类号： C12N15/86 ,  C12N15/26 ,  C07K14/075 ,  A61K48/00 ,  C12N7/01 ,  A61K39/235

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/55 ,  C12N2710/10343

摘要： Use of a recombinant adenovirus of animal origin containing a heterologuous DNA sequence for the preparation of a pharmaceutical composition for use in the therapeutic and/or surgical treatment of the human body.

公开(公告)号：EP0719332B1

公开(公告)日：2004-07-28

申请号：EP94925523.6

申请日：1994-08-22

申请人： Aventis Pharma S.A. ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： HADDADA, Hedi ,  LOPEZ, Manuel ,  PERRICAUDET, Michel

IPC分类号： C12N15/23 ,  C12N15/28 ,  C12N5/10 ,  A61K48/00 ,  C07K14/525 ,  C07K14/57

CPC分类号： C07K14/57 ,  A61K38/00 ,  A61K48/00 ,  C07K14/525

摘要： Cell compositions containing mononuclear phagocyte systems cells, and their use in cell therapy, e.g. adoptive immunotherapy, are disclosed.

公开(公告)号：EP0809516B1

公开(公告)日：2001-08-22

申请号：EP96903080.8

申请日：1996-02-12

申请人： Aventis Pharma S.A. ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： BACH, Jean-François ,  CHATENOUD, Lucienne ,  HADDADA, Hedi ,  LEE, Martin ,  PERRICAUDET, Michel ,  WEBB, Michelle

IPC分类号： A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343

摘要： A medicinal combination of at least one immunosuppressive agent and at least one recombinant adenovirus with a genome that includes a first recombinant DNA containing a therapeutic gene, and a second recombinant DNA containing an immunoprotective gene, for consecutive, intermittent and/or simultaneous use in in vivo and/or ex vivo exogenic transfections.