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12 条记录 (耗时 0.02 秒)

    MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF SUCCINATE
    1.
    发明公开
    MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF SUCCINATE 审中-公开

    公开(公告)号：EP3502241A1

    公开(公告)日：2019-06-26

    申请号：EP17209645.5

    申请日：2017-12-21

    申请人： BASF SE

    发明人： HOFF, Birgit ,  BOEHMER, Nico ,  HAEFNER, Stefan ,  SCHROEDER, Hartwig ,  ZELDER, Oskar ,  WITTMANN, Christoph ,  SCHROER, Anna Christine

    IPC分类号： C12N9/02 ,  C12P7/46

    摘要： The present invention relates to a process of producing an organic compound, the process comprising
    I) cultivating a genetically modified microorganism in a culture medium comprising at least one assimilable carbon source to allow the genetically modified microorganism to produce the organic compound,
    II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises
    A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the udhA -gene, compared to the original microorganism that has not been genetically modified,

    and wherein the original microorganism belongs to the family Pasteurellaceae.
    The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from at least one assimilable carbon source.

    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE
    9.
    发明授权
    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE 有权
    辅酶A的生产过程和重组微生物

    公开(公告)号：EP2678421B1

    公开(公告)日：2018-04-11

    申请号：EP12749577.8

    申请日：2012-02-20

    申请人： BASF SE

    发明人： WITTMANN, Christoph ,  KIND, Stefanie

    IPC分类号： C12N9/88 ,  C12P13/00 ,  C12R1/15

    CPC分类号： C12P13/02 ,  C07K14/34 ,  C12N9/88 ,  C12N15/77 ,  C12P13/001

    摘要： Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as recombinant DNA molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced N-acetylcadaverine forming activity. Processes for the production of cadaverine N-acetylcadaverine using the recombinant microorganisms are also provided.

    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE
    10.
    发明公开
    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE 有权
    VERFAHREN UND REKOMBINANTE MIKROORGANISMEN ZUR HERSTELLUNG VON CADAVERIN

    公开(公告)号：EP2678421A1

    公开(公告)日：2014-01-01

    申请号：EP12749577.8

    申请日：2012-02-20

    申请人： BASF SE

    发明人： WITTMANN, Christoph ,  KIND, Stefanie

    IPC分类号： C12N1/21 ,  C12P13/00 ,  C12N15/31 ,  C12R1/15

    CPC分类号： C12P13/02 ,  C07K14/34 ,  C12N9/88 ,  C12N15/77 ,  C12P13/001

    摘要： Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as recombinant DNA molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced N-acetylcadaverine forming activity. Processes for the production of cadaverine N-acetylcadaverine using the recombinant microorganisms are also provided.

    摘要翻译： 本发明提供了包含脱氨基形式的DNA分子的重组微生物，其改善了尸胺或N-乙酰基尸胺的产生，以及用于产生微生物的重组DNA分子和多肽。 所述微生物包含细胞内赖氨酸脱羧酶活性和去调节的尸胺出口活性，或包含降低的尸胺出口活性和增强的N-乙酰胆固醇形成活性。 还提供了使用重组微生物生产尸胺N-乙酰胆固醇的方法。