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1.发明公开RETROVIRAL VECTORS CAPABLE OF EXPRESSING MULTIMERIC PROTEINS FROM MULTIPLE TRANSLATIONAL INITIATION SITES 失效一起若干转换灌顶，度假村表达多聚体蛋白质的能力RETRO病毒载体
公开(公告)号：EP0706319A1
公开(公告)日：1996-04-17
申请号：EP94909464.0
申请日：1994-01-17
IPC分类号： C12N15 , A61K31 , A61K35 , A61K38 , A61K48 , A61P37 , C07K14 , C12N5 , C12N7 , C12P21 , C12R1
CPC分类号： C12N15/86 , C07K14/70539 , C12N15/79 , C12N2740/13043 , C12N2800/108 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85
摘要： This invention relates to retroviral vectors that express multiple polypeptide subunits of a eukaryotic protein from a single polycistronic mRNA and the proteins produced from these vectors. The expressed proteins are particularly useful for inducing transplantation tolerance and the vectors are useful as agents for mediating gene transfer into eukaryotic cells.
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公开(公告)号：EP0574512B1
公开(公告)日：2003-02-05
申请号：EP92907958.0
申请日：1992-03-06
发明人： SEED, Brian , ROMEO, Charles , KOLANUS, Waldemar
CPC分类号： C12N9/1205 , A61K35/13 , A61K35/15 , A61K35/17 , A61K35/545 , A61K38/00 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00 , C07K2319/033 , C07K2319/32
摘要： Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
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公开(公告)号：EP1032418A1
公开(公告)日：2000-09-06
申请号：EP98918285.2
申请日：1998-04-14
发明人： SEED, Brian
IPC分类号： A61K39/12 , A61K39/245 , A61K39/25
CPC分类号： C12N15/86 , C07K14/005 , C12N15/85 , C12N2710/16222 , C12N2710/16243 , C12N2800/108
摘要： Disclosed herein are nucleic acid sequences which support episomal replication in a mammalian cell. These nucleic acid sequences, which have a length of less than 3 kb, include (a) an OriP sequence and (b) an EBNA1 sequence operably linked to a promoter.
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公开(公告)号：EP0929564A1
公开(公告)日：1999-07-21
申请号：EP97941703.0
申请日：1997-09-18
发明人： SEED, Brian , HAAS, Jurgen
CPC分类号： C07K14/005 , C07K14/43595 , C07K14/755 , C07K2319/00 , C12N15/67 , C12N2740/16122 , C12P21/02
摘要： The invention features a synthetic gene encoding a protein normally expressed in a mammalian cell wherein at least one non-preferred or less preferred codon in the natural gene encoding the protein has been replaced by a preferred codon encoding the same amino acid.
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公开(公告)号：EP0489780B1
公开(公告)日：1998-11-04
申请号：EP90912715.1
申请日：1990-08-28
IPC分类号： C12N15/62
CPC分类号： C07K14/62 , C07K2319/00 , C07K2319/02 , C07K2319/35 , C07K2319/75 , C12N15/62
摘要： Fusion proteins are obtained in high yields if a mixed oligonucleotide is constructed which codes for the ballast constituent of the fusion protein. The oligonucleotide mixture is introduced in a vector in such a manner that it is functionally linked to a regulatory region and to the structural gene for the desired protein. Appropriate host cells are transformed with the plasmid population obtained in this manner and the clones producing a high yield of coded fusion protein are selected.
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公开(公告)号：EP0852627A1
公开(公告)日：1998-07-15
申请号：EP96911803.0
申请日：1996-04-18
发明人： LEDER, Philip , SEED, Brian , STRANGER, Ben, Z. , LEE, Tae-Ho , KIM, Emily
IPC分类号： G01N33 , A61K48 , C07K14 , C07K16 , C12N5 , C12N9 , C12N15 , C12P21 , C12Q1 , A61K38 , C12R1
CPC分类号： C12N9/12 , A61K38/00 , C07K14/715 , C07K16/24
摘要： Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.
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公开(公告)号：EP0833650A1
公开(公告)日：1998-04-08
申请号：EP96921519.0
申请日：1996-06-11
发明人： SEED, Brian , POUYANI, Tara
IPC分类号： C12N15 , A61K38 , A61P5 , A61P9 , A61P11 , A61P13 , A61P15 , A61P29 , A61P31 , A61P37 , C07K14 , C07K16
CPC分类号： C07K14/70596 , A61K38/00 , C07K14/4727 , C07K14/473 , C07K14/705 , C07K2319/00
摘要： Disclosed herein are organic molecules to which are covalently bonded a sialyl-Lex determinant and a sulfated determinant, at least one of these determinants being positioned at a non-naturally occurring site on the molecule. Also disclosed are particular P-selectin ligands and P-selectin ligand-antibody fusions. These moecules, ligands, and fusion proteins find use in methods of reducing or protecting against inflammation and extravasation-dependent adverse reactions, such as organ damage and clotting (for example, associated with adult respiratory distress syndrome or ischemic myocardial injury).
摘要翻译： 本文公开了与唾液酸化-Sleyl决定子和硫酸化决定子共价结合的有机分子，这些决定子中的至少一个位于分子上的非天然存在位点。 还公开了特定的P-选择素配体和P-选择素配体 - 抗体融合体。 这些小分子，配体和融合蛋白可用于减少或防止炎症和外渗依赖性不良反应，例如器官损伤和凝血（例如，与成人呼吸窘迫综合征或缺血性心肌损伤相关）。
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公开(公告)号：EP0489780A1
公开(公告)日：1992-06-17
申请号：EP90912715.0
申请日：1990-08-28
CPC分类号： C07K14/62 , C07K2319/00 , C07K2319/02 , C07K2319/35 , C07K2319/75 , C12N15/62
摘要： On obtient des hauts rendements de protéines de fusion en construisant un oligonucléotide mélangé qui code pour le constituant de ballast de ladite protéine de fusion. On introduit le mélange oligonucléotide dans un vecteur de telle manière qu'il est lié fonctionnellement à une zone de régulation ainsi qu'au gène de structure pour la protéine desirée. Des cellules hôtes convenables sont transformées avec la population plasmide ainsi obtenue, les clones donnant un haut rendement de protéine de fusion codée étant sélectionnés.
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公开(公告)号：EP2178559B1
公开(公告)日：2015-06-24
申请号：EP08794573.9
申请日：2008-07-18
发明人： SEED, Brian , WOLFE, Jia, Liu , TSAI, Chia-Lun
IPC分类号： A61K39/106 , C07K14/195 , C07K14/28
CPC分类号： C07K14/28
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公开(公告)号：EP0781329B2
公开(公告)日：2010-12-29
申请号：EP95931798.3
申请日：1995-09-08
发明人： SEED, Brian
CPC分类号： C07K14/005 , C07K14/43595 , C07K14/70503 , C12N15/67 , C12N15/85 , C12N2740/16122
摘要： The invention features a synthetic gene encoding a protein normally expressed in mammalian cells wherein at least one non-preferred or less preferred codon in the natural gene encoding the mammalian protein has been replaced by a preferred codon encoding the same amino acid.
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