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公开(公告)号：EP0332080B1
公开(公告)日：1992-05-20
申请号：EP89103764.0
申请日：1989-03-03
发明人： Sugawara, Koko , Hatori, Masami , Kamei, Hideo , Konishi, Masataka , Oki, Toshikazu , Tomita, Koji
IPC分类号： C07D303/36 , C12P17/02 , C12N1/20 , A61K31/335
CPC分类号： C12R1/55 , C07D303/36 , C12P17/02
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公开(公告)号：EP0408336B1
公开(公告)日：1994-09-07
申请号：EP90307579.4
申请日：1990-07-11
发明人： Ohkuma, Hiroaki , Tomita, Koji , Konishi, Masataka , Kamei, Hideo
IPC分类号： C07D309/32 , C12P17/06 , C12N1/20 , A61K31/35
CPC分类号： C07D309/32
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公开(公告)号：EP0479505A1
公开(公告)日：1992-04-08
申请号：EP91308869.6
申请日：1991-09-27
发明人： Sawada, Yosuke , Saitoh, Kyoichiro , Hatori, Masami , Miyaki, Takeo , Oki, Toshikazu , Tomita, Koji
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56 , C12N1/20
CPC分类号： C07H15/244
摘要： The present invention relates to novel antifungal antibiotics herein designated as pradimicin L and pradimicin FL, and derivatives thereof. Pradimicins L and FL are produced by Actinomadura verrucosospora subsp. neohibisca strain R103-3, ATCC No. 53930.
摘要翻译： 本发明涉及本文中称为普拉定霉素L和普拉定霉素FL的新型抗真菌抗生素及其衍生物。 Pradimicins L和FL由Actinomadura verrucosospora subsp。 新罗非鱼菌株R103-3，ATCC No.53930。
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公开(公告)号：EP0408336A2
公开(公告)日：1991-01-16
申请号：EP90307579.4
申请日：1990-07-11
发明人： Ohkuma, Hiroaki , Tomita, Koji , Konishi, Masataka , Kamei, Hideo
IPC分类号： C07D309/32 , C12P17/06 , C12N1/20 , A61K31/35
CPC分类号： C07D309/32
摘要： The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.
摘要翻译： 本发明涉及抗肿瘤抗生素化合物BU-3285T及其制备方法。 该化合物通过培养一种新的连翘蔷薇菌株获得，并表现出抗肿瘤和抗真菌活性。 它还涉及通过用硫酸酯酶处理BU-3285T获得的BU-3285T的脱硫衍生物。 BU-3285T硫酸盐具有抗肿瘤活性。
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公开(公告)号：EP0337430A3
公开(公告)日：1991-07-24
申请号：EP89106518.7
申请日：1989-04-12
发明人： Hofstead, Sandra June , Matson, James Andrew , Lam, Kin Sing , Forenza, Salvatore , Bush, James Allen , Tomita, Koji
摘要： Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues. Kedarcidin has the following sequence:
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公开(公告)号：EP0277621A1
公开(公告)日：1988-08-10
申请号：EP88101410.4
申请日：1988-02-01
发明人： Oki, Toshikazu , Saitoh, Kyoichiro , Tomatsu, Kozo , Tomita, Koji , Konishi, Masataka , Miyaki, Takeo , Tsunakawa, Mitsuaki , Nishio, Maki
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56
摘要： Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
摘要翻译： 本文命名为BU-3608，BU-3608B和BU-3608C的新型抗生素通过发行Actinomadura hibisca菌株P157-2，ATCC 53557和菌株Q278-4，ATCC 53646产生。抗生素具有 抗真菌和抗病毒活性。
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公开(公告)号：EP0337430B1
公开(公告)日：1994-02-16
申请号：EP89106518.7
申请日：1989-04-12
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公开(公告)号：EP0329109B1
公开(公告)日：1992-11-19
申请号：EP89102599.1
申请日：1989-02-15
发明人： Lam, Kin Sing , Mattei, Jacqueline , Leet, John Emerick , Matson, James Andrew , Tomita, Koji , Kaplan, Murray A.
摘要： A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
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公开(公告)号：EP0423818A1
公开(公告)日：1991-04-24
申请号：EP90120104.6
申请日：1990-10-19
发明人： Sawada, Yosuke , Ueki, Tomokazu , Yamamoto, Satoshi , Tomita, Koji , Fukagawa, Yasuo , Oki, Toshikazu
CPC分类号： B82Y5/00 , A61K47/50 , A61K47/6899 , C12N9/16 , C12R1/465
摘要： The present invention relates to an arylsulfatase of microbial origin. The enzyme may be linked to an antibody against a tumor-associated antigen and the resulting conjugate used in conjuction with a sulfated prodrug of a 4′-demethylepipodophyllotoxin glucoside derivative, particularly etoposide in cancer chemotherapy.
摘要翻译： 本发明涉及微生物来源的芳基硫酸酯酶。 该酶可以与针对肿瘤相关抗原的抗体连接，所得到的缀合物与4分钟的硫酸化前药结合使用 - 甲氧基表鬼臼毒素葡糖苷衍生物，特别是癌症化学疗法中依托泊苷。
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公开(公告)号：EP0408336A3
公开(公告)日：1991-04-03
申请号：EP90307579.4
申请日：1990-07-11
发明人： Ohkuma, Hiroaki , Tomita, Koji , Konishi, Masataka , Kamei, Hideo
IPC分类号： C07D309/32 , C12P17/06 , C12N1/20 , A61K31/35
CPC分类号： C07D309/32
摘要： The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.
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