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公开(公告)号：EP2379096A2
公开(公告)日：2011-10-26
申请号：EP09833887.4
申请日：2009-12-21
申请人： Baxter International Inc. , Baxter Healthcare SA , 3b Pharmaceuticals GmbH , Cosmix Molecular Biologicals GmbH
发明人： DOCKAL, Michael , EHRLICH, Hartmut , SCHEIFLINGER, Friedrich , REIMER, Ulf , REINEKE, Ulrich , POLAKOWSKI, Thomas , SCHNEIDER, Eberhard
IPC分类号： A61K38/00
摘要： The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, and/or treat a blood coagulation disorder in a subject.
摘要翻译： 本发明提供了结合组织因子途径抑制剂（TFPI）（包括TFPI抑制肽）及其组合物的肽。 肽可以用于抑制TFPI，增强凝血因子缺陷受试者中的凝血酶形成，增加受试者中的血块形成和/或治疗受试者的血液凝固障碍。
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2.发明公开FVIII PEPTIDES FOR IMMUNE TOLERANCE INDUCTION AND IMMUNODIAGNOSTICS 有权FVIII-PEPTIDE ZUR IMMUNTOLERANZINDUKTION UND IMMUNDIAGNOSTIK
公开(公告)号：EP2632479A1
公开(公告)日：2013-09-04
申请号：EP11796846.1
申请日：2011-10-27
发明人： STEINITZ, Katharina, Nora , WILHELMINA VAN HELDEN, Paula, Maria , REIPERT, Birgit, Maria , SCHWARZ, Hans-Peter , EHRLICH, Hartmut
IPC分类号： A61K38/37 , C07K14/755 , A61P7/04
CPC分类号： C07K14/755 , A61K38/37 , C07K2319/00 , C12P21/00 , G01N33/505 , G01N33/56977
摘要： The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII- specific CD4
+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.摘要翻译： 本发明涉及可用于减少针对FVIII的免疫应答或诱导对例如血友病A的患者对人FVIII的耐受性的肽。此外，该肽可用于免疫诊断目的以检测FVIII-特异性CD4 + T细胞在替代治疗期间和免疫耐受诱导治疗期间监测血友病A患者。
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公开(公告)号：EP2838561A1
公开(公告)日：2015-02-25
申请号：EP13728681.1
申请日：2013-04-16
IPC分类号： A61K39/395 , C07K16/24 , A61K31/7068 , A61K31/704 , A61K33/24 , A61K31/137 , A61P35/00
CPC分类号： A61K39/3955 , A61K31/136 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K2039/505 , A61K2039/545 , C07K16/24 , C07K2317/21 , C07K2317/76 , A61K2300/00
摘要： The present invention pertains to anti-MIF antibodies, in particular their use in combination with therapeutics, i.e. chemotherapeutics, in the treatment of cancer.
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公开(公告)号：EP2838559A1
公开(公告)日：2015-02-25
申请号：EP13718822.3
申请日：2013-04-16
IPC分类号： A61K39/395 , C07K16/24 , A61K31/573
摘要： The present invention pertains to anti-MIF antibodies, in particular their use in combination with glucocorticoids, in the treatment of glycocorticoid receptive diseases.
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5.发明公开RECOMBINANT VIRAL VECTORS AND METHODS FOR INDUCING AN IMMUNE RESPONSE TO YELLOW FEVER VIRUS 审中-公开重组病毒载体和方法进行部署的免疫应答黄热病病毒抗原
公开(公告)号：EP2618840A2
公开(公告)日：2013-07-31
申请号：EP11764065.6
申请日：2011-09-22
IPC分类号： A61K39/12 , C12N15/863
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , C12N2710/24143 , C12N2770/24134 , Y02A50/388
摘要： The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to yellow fever virus. The invention provides recombinant viral vectors based on the non-replicating modified vaccinia virus Ankara or based on a D4R-defective vaccinia virus. When administered according to methods of the invention, the recombinant viral vectors induce a broad immune response to yellow fever virus and demonstrate an excellent safety profile.
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公开(公告)号：EP2547355A2
公开(公告)日：2013-01-23
申请号：EP11756689.3
申请日：2011-02-11
发明人： DOCKAL, Michael , HARTMANN, Rudolf , FRIES, Markus , SCHEIFLINGER, Friedrich , EHRLICH, Hartmut , REINEKE, Ulrich , OSTERKAMP, Frank , POLAKOWSKI, Thomas
IPC分类号： A61K38/18
CPC分类号： A61K38/10 , A61K38/00 , A61K2121/00 , C07K1/14 , C07K7/08 , C07K14/00 , C07K14/8114 , G01N33/68 , G01N2333/745 , G01N2333/8114 , G01N2333/96444 , G01N2333/96447 , G01N2500/02 , G01N2500/04 , G01N2500/20 , G06F19/16 , G06F19/18
摘要： The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
摘要翻译： 本发明提供了结合组织因子途径抑制剂（TFPI）的肽，包括TFPI抑制肽及其组合物。 所述肽可用于抑制TFPI，增强凝血因子缺陷受试者中的凝血酶形成，增加受试者的血块形成，治疗受试者中的凝血障碍，纯化TFPI并鉴定TFPI结合化合物。
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公开(公告)号：EP2523553A1
公开(公告)日：2012-11-21
申请号：EP11733408.6
申请日：2011-01-13
IPC分类号： A01N43/04 , A61K31/715 , A61K31/727
CPC分类号： G01N33/86 , A61K31/737 , A61K38/36 , A61K38/37 , Y10T436/106664 , Y10T436/107497 , Y10T436/178459 , Y10T436/18 , Y10T436/255 , A61K2300/00
摘要： Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a non-anticoagulant sulfated polysaccharide (NASP) is administered to a subject to enhance blood coagulation in the subject. Also provided are methods for preparing a NASP composition having blood coagulation enhancing activity. Compositions and kits for practicing methods of the invention are also described.
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8.发明公开DETECTION OF ANTIBODY THAT BINDS TO WATER SOLUBLE POLYMER-MODIFIED POLYPEPTIDES 审中-公开AN水可溶聚合物证明修饰多肽结合抗体
公开(公告)号：EP2435833A1
公开(公告)日：2012-04-04
申请号：EP10727212.2
申请日：2010-05-25
发明人： LUBICH, Christian , SIEKMANN, Juergen , REIPERT, Birgit, Maria , SCHWARZ, Hans-Peter , EHRLICH, Hartmut
IPC分类号： G01N33/68
CPC分类号： G01N33/6854
摘要： The present invention provides analytical methods for detecting anti- polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
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9.发明授权IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE 有权趋化因子的IVIG调制多发性硬化症的治疗，老年痴呆症和帕金森氏症
公开(公告)号：EP2191014B1
公开(公告)日：2013-04-03
申请号：EP08785488.1
申请日：2008-08-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
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10.发明授权RECOMBINANT VIRAL VECTORS AND METHODS FOR INDUCING A HETEROSUBTYPIC IMMUNE RESPONSE TO INFLUENZA A VIRUSES 有权重组病毒载体和方法引入HETEROSUBTYPISCHEN免疫反应甲型流感病毒
公开(公告)号：EP2670430B1
公开(公告)日：2015-04-01
申请号：EP12702162.4
申请日：2012-01-30
发明人： FALKNER, Falko-Günter , SCHÄFER, Birgit , HESSEL, Annett , BARRETT, P., Noel , KREIL, Thomas, R. , EHRLICH, Hartmut
IPC分类号： A61K39/145 , C07K14/11
CPC分类号： C12N15/86 , A61K39/12 , A61K39/145 , A61K39/285 , A61K2039/5256 , A61K2039/5258 , A61K2039/70 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N2710/24122 , C12N2710/24123 , C12N2710/24134 , C12N2710/24143 , C12N2760/16134
摘要： The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.
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