公开(公告)号：EP1148879A2

公开(公告)日：2001-10-31

申请号：EP00909096.0

申请日：2000-01-24

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  HINZEN, Berthold ,  KRÄMER, Thomas ,  PERNERSTORFER, Josef ,  STÜDEMANN, Thomas ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  LOHRMANN, Emanuel ,  GERDES, Christoph ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  MAYR, Lorenz

IPC分类号： A61K31/4155 ,  A61K31/443 ,  A61P7/06 ,  C07D231/12

CPC分类号： C07D231/12 ,  A61K31/415 ,  C07D401/04 ,  C07D409/04

摘要： The present invention relates to novel and known pyrazole carboxamides of general formulae (I and Ia), whereby A, A', D, D', E, E', G, G', R1, R'1, R2 and L have the meaning as given in the description. The invention also relates to the production of pyrazole carboxamides by means of solid phase chemistry or novel pyrazole carboxamides. The pyrazole carboxamides are used as medicaments, especially (oral) medicaments for the treatment of anaemias. Said carboxamides stimulate the EPO production (erythropoesis) and can be used with own blood donors.

公开(公告)号：EP1150958A1

公开(公告)日：2001-11-07

申请号：EP00910605.5

申请日：2000-01-24

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  HINZEN, Berthold ,  KRÄMER, Thomas ,  PERNERSTORFER, Josef ,  STÜDEMANN, Thomas ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  LOHRMANN, Emanuel ,  GERDES, Christoph ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  MAYR, Lorenz

IPC分类号： C07D231/12 ,  C07D409/04 ,  A61K31/415 ,  A61P7/06 ,  C07D401/04 ,  C07D405/04

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04

摘要： The invention relates to methods for the production of substituted pyrazole carboxylic acids of general formula (I). The key step is cyclization with hydrazines followed by saponification. The substituted pyrazole carboxylic acids are used as medicaments, especially as medicaments in the treatment and prophylaxis of anaemias.

公开(公告)号：EP1140768A1

公开(公告)日：2001-10-10

申请号：EP99963582.4

申请日：1999-12-20

申请人： Bayer Aktiengesellschaft

发明人： FITZGERALD, Mary, F. ,  GARDINER, Philip, J. ,  NASH, Kevin ,  STURTON, Graham ,  BENZ, Günter ,  HENNING, Rolf ,  SCHLEMMER, Karl-Heinz ,  RIEDL, Bernd ,  HANING, Helmut ,  MAYR, Lorenz

IPC分类号： C07C59/88 ,  C07C59/48 ,  C07C59/68 ,  C07D317/46 ,  C07D253/08 ,  A61K31/40 ,  A61K31/53 ,  A61P11/00 ,  A61P29/00

CPC分类号： C07D209/48 ,  A61K31/40 ,  C07D253/08 ,  C07D491/04

摘要： Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of Respiratory Diseases, pharmaceutical compositions containing them, and a process for using them. The compounds of the invention have the generalized formula (I) (T)xA-B-D-E-CO2H wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group, x is 0, 1, or 2; the group D represents (a), (b), (c), or (d); the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and each of the substituents on E is an independent substituent; and include pharmaceutically acceptable salts thereof.