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公开(公告)号：EP1148879A2
公开(公告)日：2001-10-31
申请号：EP00909096.0
申请日：2000-01-24
发明人： STOLTEFUSS, Jürgen , BRÄUNLICH, Gabriele , HINZEN, Berthold , KRÄMER, Thomas , PERNERSTORFER, Josef , STÜDEMANN, Thomas , NIELSCH, Ulrich , BECHEM, Martin , LOHRMANN, Emanuel , GERDES, Christoph , SPERZEL, Michael , LUSTIG, Klemens , MAYR, Lorenz
IPC分类号： A61K31/4155 , A61K31/443 , A61P7/06 , C07D231/12
CPC分类号： C07D231/12 , A61K31/415 , C07D401/04 , C07D409/04
摘要： The present invention relates to novel and known pyrazole carboxamides of general formulae (I and Ia), whereby A, A', D, D', E, E', G, G', R1, R'1, R2 and L have the meaning as given in the description. The invention also relates to the production of pyrazole carboxamides by means of solid phase chemistry or novel pyrazole carboxamides. The pyrazole carboxamides are used as medicaments, especially (oral) medicaments for the treatment of anaemias. Said carboxamides stimulate the EPO production (erythropoesis) and can be used with own blood donors.
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2.发明公开
公开(公告)号：EP1150958A1
公开(公告)日：2001-11-07
申请号：EP00910605.5
申请日：2000-01-24
发明人： STOLTEFUSS, Jürgen , BRÄUNLICH, Gabriele , HINZEN, Berthold , KRÄMER, Thomas , PERNERSTORFER, Josef , STÜDEMANN, Thomas , NIELSCH, Ulrich , BECHEM, Martin , LOHRMANN, Emanuel , GERDES, Christoph , SPERZEL, Michael , LUSTIG, Klemens , MAYR, Lorenz
IPC分类号： C07D231/12 , C07D409/04 , A61K31/415 , A61P7/06 , C07D401/04 , C07D405/04
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D409/04
摘要： The invention relates to methods for the production of substituted pyrazole carboxylic acids of general formula (I). The key step is cyclization with hydrazines followed by saponification. The substituted pyrazole carboxylic acids are used as medicaments, especially as medicaments in the treatment and prophylaxis of anaemias.
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