公开(公告)号：EP1497269A1

公开(公告)日：2005-01-19

申请号：EP03720434.4

申请日：2003-04-08

申请人： Bayer HealthCare AG

发明人： SCHOHE-LOOP, Rudolf ,  BURCHARDT, Elmar ,  FAESTE, Christiane ,  HIRTH-DIETRICH, Claudia ,  KELDENICH, Jörg ,  KNORR, Andreas ,  LAMPE, Thomas ,  NAAB, Paul ,  SCHMIDT, Delf ,  SCHMIDT, Gunter

IPC分类号： C07D237/22 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  A61K31/501 ,  A61P1/16

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D237/22 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12

摘要： The invention relates to substituted 2-phenyl-3(2h)-pyridazinones, to a method for the production thereof, and to their use as medicaments used in the prophylaxis and/or treatment of diseases in humans and/or animals.

公开(公告)号：EP1406891B1

公开(公告)日：2006-03-22

申请号：EP02805269.4

申请日：2002-05-21

申请人： Bayer HealthCare AG

发明人： MEIER, Heinrich ,  ALLERHEILIGEN, Swen ,  GERISCH, Michael ,  SCHOHE-LOOP, Rudolf ,  VOERSTE, Arnd ,  MAULER, Frank ,  DE VRY, Jean, Marie, Victor ,  MÜLLER, Thomas ,  METHFESSEL, Christoph

IPC分类号： C07D335/06 ,  C07D335/16 ,  A61K31/382 ,  A61P25/28

CPC分类号： C07D409/04 ,  A61K31/382 ,  C07D335/04 ,  C07D335/16 ,  C07D409/10 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D491/10

摘要： The invention relates to thiochromenones, to methods for the production thereof, and to the use of the same for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of painful conditions and/or neurodegenerative diseases.

公开(公告)号：EP1572642A1

公开(公告)日：2005-09-14

申请号：EP03789084.5

申请日：2003-11-26

申请人： Bayer HealthCare AG

发明人： ZIMMERMANN, Holger ,  BRÜCKNER, David ,  HEIMBACH, Dirk ,  HENNINGER, Kerstin ,  HEWLETT, Guy ,  ROSENTRETER, Ulrich ,  SCHOHE-LOOP, Rudolf ,  BAUMEISTER, Judith ,  SCHMIDT, Thorsten ,  REEFSCHLÄGER, Jürgen ,  LANG, Dieter ,  LIN, Tse-I ,  RADTKE, Martin

IPC分类号： C07D207/34 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4025 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D405/06

CPC分类号： C07D401/06 ,  C07D207/34 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The invention relates to substituted pyrroles of formula (I), in which: R1 represents -OR8 or -NR9R10; R2 represents hydrogen, C1-C6 alkyl or aryl, whereby R2 as an alkyl can be substituted with 0, 1, 2 or 3 substituents R2-1 independently of one another, selected from the group comprising halogen, hydroxy, C1-C6 alkoxy, hydroxycarbonyl, C1-C6 alkoxycarbonyl, C1-C6 alkylcarbonyloxy, amino, C1-C6 alkylamino, aminocarbonyl, C1-C6 alkylaminocarbonyl, C3-C8 cycloalkyl, a 5- to 10-membered heterocyclyl, C6-C10 aryl, phenoxy and a 5- to 10-membered heteroaryl and whereby R2 as an aryl can be substituted with 0, 1, 2 or 3 substituents R2-2 independently of one another, selected from the group comprising halogen, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, C1-C6 alkyl, C1-C6 alkoxy, hydroxycarbonyl, C1-C6 alkoxycarbonyl, amino, C1-C6 alkylamino, aminocarbonyl, C1-C6 alkylaminocarbonyl, C3-C8 cycloalkyl, a 5- to 10-membered heterocyclyl, C6-C10 aryl and a 5- to 10-membered heteroaryl; R3 and R4 independently of one another represent hydrogen or C1-C6 alkyl; R5 and R6 independently of one another represent hydrogen or C1-C6 alkyl; and R7 represents a 3- to 12-membered carbocyclyl, whereby the carbocyclyl can be substituted with 0, 1, 2, 3, 4 or 5 substituents independently of one another, selected from the group comprising halogen, hydroxy, C1-C6 alkyl and C1-C6 alkoxy. The invention also relates to a method for producing said pyrroles, to their use for the treatment and/or prophylaxis of diseases, in addition to their use for producing medicaments for the treatment and/or prophylaxis of diseases, notably to their use as antiviral agents, in particular against cytomegaloviruses.

公开(公告)号：EP1966218A1

公开(公告)日：2008-09-10

申请号：EP06840964.8

申请日：2006-12-08

申请人： Bayer HealthCare AG

发明人： LAMPE, Thomas ,  BECKER, Eva-Maria ,  KAST, Raimund ,  BECK, Hartmut ,  JESKE, Mario ,  SCHUHMACHER, Joachim ,  STOLL, Friederike ,  KLEIN, Martina ,  AKBABA, Metin ,  KNORR, Andreas ,  STASCH, Johannes-Peter ,  BÄRFACKER, Lars ,  HILLISCH, Alexander ,  KARIG, Gunter ,  MEININGHAUS, Mark ,  SCHLEMMER, Karl-Heinz ,  SCHOHE-LOOP, Rudolf

IPC分类号： C07D491/04 ,  A61K31/519 ,  A61P9/00

CPC分类号： C07D491/04

摘要： The invention relates to novel, cyclic substituted furopyrimidine derivatives represented by formula (I), to methods for the production thereof, to the use thereof for treating and/or for the prophylaxis of illnesses and to the use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular for treating and/or for the prophylaxis of cardiovascular diseases.

公开(公告)号：EP1966217A1

公开(公告)日：2008-09-10

申请号：EP06829427.1

申请日：2006-12-08

申请人： Bayer HealthCare AG

发明人： LAMPE, Thomas ,  BECKER, Eva-Maria ,  KAST, Raimund ,  BECK, Hartmut ,  JESKE, Mario ,  SCHUHMACHER, Joachim ,  STOLL, Friederike ,  KLEIN, Martina ,  AKBABA, Metin ,  KNORR, Andreas ,  STASCH, Johannes-Peter ,  BÄRFACKER, Lars ,  HILLISCH, Alexander ,  KARIG, Gunter ,  MEININGHAUS, Mark ,  SCHLEMMER, Karl-Heinz ,  SCHOHE-LOOP, Rudolf

IPC分类号： C07D491/04 ,  A61K31/519 ,  A61P9/00

CPC分类号： C07D491/04

摘要： The invention relates to novel, acyclic substituted furopyrimidine derivatives represented by formula (I), to methods for the production thereof, to the use thereof for treating and/or for the prophylaxis of illnesses and to the use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular for treating and/or for the prophylaxis of cardiovascular diseases.

公开(公告)号：EP1583967A2

公开(公告)日：2005-10-12

申请号：EP03795968.1

申请日：2003-12-24

申请人： Bayer HealthCare AG

发明人： BETZ, Ulrich ,  HEWLETT, Guy ,  KLEYMANN, Gerald ,  LAMPE, Thomas ,  LIN, Tse-I ,  NIKOLIC, Susanne ,  REEFSCHLÄGER, Jürgen ,  WUNBERG, Tobias ,  ZIMMERMANN, Holger ,  ZUMPE, Franz ,  BENDER, Wolfgang ,  HENNINGER, Kerstin ,  JENSEN, Axel ,  KELDENICH, Jörg ,  SCHOHE-LOOP, Rudolf

IPC分类号： G01N33/569 ,  A61P31/22

CPC分类号： C07C311/08 ,  C07C275/40 ,  C07D237/04 ,  G01N33/56994 ,  G01N2500/00

摘要： The invention relates to a method for inhibiting the replication of herpes viruses, to methods for identifying compounds that inhibit the replication of herpes viruses with this method, to compounds with activity directed against herpes viruses, to methods for producing these compounds, and to the use thereof for producing medicaments used in the treatment of herpes infections.

公开(公告)号：EP1472229A1

公开(公告)日：2004-11-03

申请号：EP03734671.5

申请日：2003-01-16

申请人： Bayer HealthCare AG

发明人： WUNBERG, Tobias ,  BETZ, Ulrich ,  KLEYMANN, Gerald ,  NIKOLIC, Susanne ,  REEFSCHLÄGER, Jürgen ,  SCHOHE-LOOP, Rudolf ,  ZIMMERMANN, Holger ,  ZUMPE, Franz ,  BENDER, Wolfgang ,  HENNINGER, Kerstin ,  HEWLETT, Guy ,  JENSEN, Axel ,  KELDENICH, Jörg

IPC分类号： C07D231/20 ,  C07D231/54 ,  C07D249/12 ,  A61K31/4152 ,  A61K31/4196 ,  A61K31/12

CPC分类号： C07D249/12 ,  C07D231/20 ,  C07D231/54

摘要： The invention relates to 5-ring heterocycles, methods for the production thereof, and the use thereof for the production of medicines used for treating or preventing diseases, particularly medicines used as antiviral agents, particularly against cytomegaloviruses.

公开(公告)号：EP1406891A1

公开(公告)日：2004-04-14

申请号：EP02805269.4

申请日：2002-05-21

申请人： Bayer HealthCare AG

发明人： MEIER, Heinrich ,  ALLERHEILIGEN, Swen ,  GERISCH, Michael ,  SCHOHE-LOOP, Rudolf ,  VOERSTE, Arnd ,  MAULER, Frank ,  DE VRY, Jean, Marie, Victor ,  MÜLLER, Thomas ,  METHFESSEL, Christoph

IPC分类号： C07D335/06 ,  C07D335/16 ,  A61K31/382 ,  A61P25/28

CPC分类号： C07D409/04 ,  A61K31/382 ,  C07D335/04 ,  C07D335/16 ,  C07D409/10 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D491/10

摘要： The invention relates to thiochromenones, to methods for the production thereof, and to the use of the same for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of painful conditions and/or neurodegenerative diseases.

摘要翻译： 本发明涉及二氢苯并噻喃酮，其制备方法以及其用于治疗和/或预防疾病，特别是用于治疗和/或预防疼痛病症和/或神经退行性疾病的用途。

公开(公告)号：EP1401436A1

公开(公告)日：2004-03-31

申请号：EP02760172.3

申请日：2002-06-10

申请人： Bayer HealthCare AG

发明人： SCHOHE-LOOP, Rudolf ,  BETZ, Ulrich ,  FISCHER, Rüdiger ,  HENDRIX, Martin ,  KLEYMANN, Gerald ,  BAUMEISTER, Judith ,  BENDER, Wolfgang ,  ECKENBERG, Peter ,  HANDKE-ERGüDEN, Gabrielle ,  HENNINGER, Kerstin ,  JENSEN, Axel ,  KELDENICH, Jörg ,  SCHNEIDER, Udo ,  WEBER, Olaf

IPC分类号： A61K31/427 ,  C07D401/12 ,  C07D277/36

CPC分类号： C07D417/12 ,  C07D277/54

摘要： The invention relates to the novel compounds of formula (I), to a method for producing the same and to their use as drugs, especially as antiviral drugs.

公开(公告)号：EP1497269B1

公开(公告)日：2008-04-23

申请号：EP03720434.4

申请日：2003-04-08

申请人： Bayer HealthCare AG

发明人： SCHOHE-LOOP, Rudolf ,  BURCHARDT, Elmar ,  FAESTE, Christiane ,  HIRTH-DIETRICH, Claudia ,  KELDENICH, Jörg ,  KNORR, Andreas ,  LAMPE, Thomas ,  NAAB, Paul ,  SCHMIDT, Delf ,  SCHMIDT, Gunter

IPC分类号： C07D237/22 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  A61K31/501 ,  A61P1/16

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D237/22 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12

摘要： The invention relates to substituted 2-phenyl-3(2h)-pyridazinones, to a method for the production thereof, and to their use as medicaments used in the prophylaxis and/or treatment of diseases in humans and/or animals.