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1.发明公开POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF 有权ADRENOMEDULLIN-PRODRUG AUF POLYETHYLINGLYKOLBASIS UND VERWENDUNG DAVON
公开(公告)号：EP3075395A1
公开(公告)日：2016-10-05
申请号：EP15192265.5
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gordon , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
摘要翻译： 本发明涉及包含新型聚乙二醇（PEG）基于前体药物的肾上腺髓质素或其盐之一，其溶剂合物或其盐的溶剂合物与惰性无毒药学上合适的赋形剂组合的药物，其中药物为药物形式 用于吸入，其用于治疗和/或预防特定PEG-肾上腺髓质素前体药物及其合成中间体的疾病，特别是心血管，水肿和/或炎症性疾病的疾病。
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公开(公告)号：EP2705038A1
公开(公告)日：2014-03-12
申请号：EP12724584.3
申请日：2012-05-02
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , STRAUB, Alexander , ACKERSTAFF, Jens , GRIEBENOW, Nils , KNORR, Andreas , WUNDER, Frank , LI, Volkhart, Min-Jian
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/53 , A61K45/06
摘要： The invention relates to novel substituted imidazopyridazines, to a method for the production thereof, to the individual or combined use thereof for the treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及具有下式（I）的新型取代的咪唑并哒嗪：其制备方法，其用途，单独或组合用于治疗和/或预防疾病及其用于生产药物的用途 治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：EP3075395B1
公开(公告)日：2017-11-22
申请号：EP15192265.5
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
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4.发明授权POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF 有权西班牙语VERWENDUNG的ADRENOMEDULLIN-PRODRUG AUF POLYETHYLINGLYKOLBASIS
公开(公告)号：EP2773376B1
公开(公告)日：2016-01-13
申请号：EP12783566.8
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
摘要翻译： 本发明涉及包含新型聚乙二醇（PEG）基于前体药物的肾上腺髓质素或其盐之一，其溶剂化物或其盐的溶剂合物与惰性无毒药学上合适的赋形剂组合的药物，其中药物为药物形式 用于吸入，其用于治疗和/或预防特定PEG-肾上腺髓质素前体药物及其合成中间体的疾病，特别是心血管，水肿和/或炎症性疾病的疾病。
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公开(公告)号：EP2773376A1
公开(公告)日：2014-09-10
申请号：EP12783566.8
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
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公开(公告)号：EP1940769B1
公开(公告)日：2016-08-10
申请号：EP06806330.4
申请日：2006-10-17
发明人： BARTEL, Stephan , HAHN, Michael , MORADI, Wahed Ahmed , BECKER, Eva-Maria , RÖLLE, Thomas , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , KNORR, Andreas , LANG, Dieter
IPC分类号： C07C65/28 , A61K31/194 , A61P9/00
CPC分类号： C07C65/28
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7.发明公开SUBSTITUIERTE 6-FLUOR-1H-PYRAZOLO[4,3-B]PYRIDINE UND IHRE VERWENDUNG 有权取代的6-氟-1H-吡唑并[4,3-b]吡啶和它们的用途
公开(公告)号：EP2635577A1
公开(公告)日：2013-09-11
申请号：EP11788085.6
申请日：2011-11-03
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , ACKERSTAFF, Jens , GRIEBENOW, Nils , KNORR, Andreas , WUNDER, Frank , LI, Volkhart, Min-Jian , MITTENDORF, Joachim , SCHLEMMER, Karl-Heinz , JAUTELAT, Rolf
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06
摘要： The invention relates to novel 6-fluoro-1h-pyrazolo[4,3-b]pyridines, to methods for producing same, to the use thereof alone or in combination for treating and/or preventing illnesses, and to the use thereof to produce drugs for treating and/or preventing illnesses, in particular for treating and/or preventing cardiovascular diseases.
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8.发明授权ANNELLIERTE 4-AMINOPYRIMIDINE UND IHRE VERWENDUNG ALS STIMULATOREN DER LÖSLICHEN GUANYLATCYCLASE 有权融合4氨基嘧啶及其作为可溶性鸟苷酸环化酶兴奋剂
公开(公告)号：EP2590987B1
公开(公告)日：2016-03-09
申请号：EP11745710.1
申请日：2011-07-05
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , ACKERSTAFF, Jens , GRIEBENOW, Nils , KNORR, Andreas , WUNDER, Frank , LI, Volkhart Min-Jian
IPC分类号： C07D519/00 , A61K31/437 , A61P9/00
CPC分类号： A61K31/519 , A61K45/06 , C07D471/04 , C07D491/20 , C07D519/00
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9.发明授权SUBSTITUIERTE 6-FLUOR-1H-PYRAZOLO[4,3-B]PYRIDINE UND IHRE VERWENDUNG 有权取代的6-氟-1H-吡唑并[4,3-b]吡啶和它们的用途
公开(公告)号：EP2635577B1
公开(公告)日：2014-10-01
申请号：EP11788085.6
申请日：2011-11-03
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , ACKERSTAFF, Jens , GRIEBENOW, Nils , KNORR, Andreas , WUNDER, Frank , LI, Volkhart, Min-Jian , MITTENDORF, Joachim , SCHLEMMER, Karl-Heinz , JAUTELAT, Rolf
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06
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公开(公告)号：EP2406215B1
公开(公告)日：2014-04-16
申请号：EP10706154.1
申请日：2010-02-24
发明人： LAMPE, Thomas , HAHN, Michael , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , HEITMEIER, Stefan , GRIEBENOW, Nils , EL SHEIKH, Sherif , LI, Volkhart, Min-Jian , BECKER, Eva-Maria , STOLL, Friederike , KNORR, Andreas
IPC分类号： C07D209/46 , C07D237/14 , C07D273/04 , A61K31/4035 , A61K31/50 , A61K31/5395 , A61P9/00
CPC分类号： C07D273/04 , A61K31/4035 , A61K31/495 , A61K31/50 , A61K31/5395 , C07D209/46 , C07D237/14
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