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1.发明公开
公开(公告)号：EP3638670A1
公开(公告)日：2020-04-22
申请号：EP18728902.0
申请日：2018-06-07
申请人： Bayer Pharma Aktiengesellschaft , Bayer Aktiengesellschaft , Deutsches Krebsforschungszentrum Heidelberg
发明人： SCHMEES, Norbert , BUCHMANN, Bernd , FRIBERG, Anders Roland , BRIEM, Hans , HUSEMANN, Manfred , BÖMER, Ulf , LEDER, Gabriele , CARRETERO, Rafael , STÖCKIGT, Detlef , OFFRINGA, Rienk
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP3638669A1
公开(公告)日：2020-04-22
申请号：EP18728901.2
申请日：2018-06-07
申请人： Bayer Pharma Aktiengesellschaft , Deutsches Krebsforschungszentrum Heidelberg , Bayer Aktiengesellschaft
发明人： BUCHMANN, Bernd , SCHMEES, Norbert , MOWAT, Jeffrey Stuart , LEDER, Gabriele , PANKNIN, Olaf , CARRETERO, Rafael , AIGUABELLA FONT, Nuria , BRIEM, Hans , FRIBERG, Anders Roland , HUSEMANN, Manfred , BÖMER, Ulf , STÖCKIGT, Detlef , NEUHAUS, Roland , BERNDT, Sandra , PETERSEN, Kirstin , OFFRINGA, Rienk
IPC分类号： C07D471/04 , A61P35/00
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公开(公告)号：EP3638671A1
公开(公告)日：2020-04-22
申请号：EP18728903.8
申请日：2018-06-07
发明人： SCHMEES, Norbert , BUCHMANN, Bernd , FRIBERG, Anders Roland , BRIEM, Hans , HUSEMANN, Manfred , BÖMER, Ulf , LEDER, Gabriele , CARRETERO, Rafael , STÖCKIGT, Detlef , OFFRINGA, Rienk
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP3390387A1
公开(公告)日：2018-10-24
申请号：EP16829402.3
申请日：2016-12-15
发明人： SCHULZE, Volker , HEINRICH, Tobias , PRINZ, Florian , LEFRANC, Julien , SCHRÖDER, Jens , MENGEL, Anne , BONE, Wilhelm , BÁLINT, Joszef , WENGNER, Antje Margret , EIS, Knut , IRLBACHER, Horst , KOPPITZ, Marcus , BÖMER, Ulf , BADER, Benjamin , BRIEM, Hans , LIENAU, Philip , CHRIST, Clara , STÖCKIGT, Detlef , HILLIG, Roman , EHEIM, Ashley , KOSEMUND, Dirk , MÖNNING, Ursula , HARB, Hassan, Y.
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61K31/407
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3177619B1
公开(公告)日：2018-04-25
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3177619A1
公开(公告)日：2017-06-14
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的所述化合物的用途 疾病作为唯一的药剂或与其他活性成分组合。
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公开(公告)号：EP3010907A1
公开(公告)日：2016-04-27
申请号：EP14738399.6
申请日：2014-06-17
发明人： HILGER, Christoph-Stephan , HITCHCOCK, Marion , BRIEM, Hans , SIEMEISTER, Gerhard , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , DENNER, Karsten
IPC分类号： C07D401/14 , C07D403/14 , C07D498/04 , A61K31/506 , A61K31/53 , A61K31/5365 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其生产方法及其作为药物的用途。
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公开(公告)号：EP3010902A1
公开(公告)日：2016-04-27
申请号：EP14730907.4
申请日：2014-06-17
发明人： HITCHCOCK, Marion , MENGEL, Anne , BRIEM, Hans , LÜCKING, Ulrich , SIEMEISTER, Gerhard , BONE, Wilhelm , SCHRÖDER, Jens , BAIRLEIN, Michaela , MÖNNING, Ursula , BRÜNING, Michael
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61K45/06 , C07D401/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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9.发明公开SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER 有权替代型环丙烯腈ALS BUB1-INHIBITOREN ZUR BEHANDLUNG VON KREBS
公开(公告)号：EP2847180A1
公开(公告)日：2015-03-18
申请号：EP13721755.0
申请日：2013-05-08
发明人： HITCHCOCK, Marion , HILGER, Christoph-Stephan , MENGEL, Anne , BRIEM, Hans , HOLTON, Simon , PÜTTER, Vera , SIEMEISTER, Gerhard , PRECHTL, Stefan , FERNÁNDEZ-MONTALVÁN, Amaury, Ernesto , STEGMANN, Christian , PREUSSE, Cornelia , GNOTH, Mark, Jean
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07D405/14 , C07F7/1856 , C07F7/188
摘要： Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
摘要翻译： 式（I）化合物，其生产方法及其作为Bub1激酶抑制剂用于治疗对诱导细胞死亡有反应的过度增殖性疾病和/或病症的用途。
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10.发明公开SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权SUBSTITUIERTE BENZYLINDAZOLE ZUR VERWENDUNG ALS BUB1-KINASEHEMMER BEI DER BEHANDLUNG HYPERPROLIFERATIVER ERKRANKUNGEN
公开(公告)号：EP2763982A1
公开(公告)日：2014-08-13
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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