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公开(公告)号：EP2618835A1
公开(公告)日：2013-07-31
申请号：EP11761508.8
申请日：2011-09-19
申请人： Biontech AG , Universitätsmedizin der Johannes Gutenberg-Universität Mainz , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
摘要翻译： 本发明涉及提供抗原特异性淋巴样细胞的有效方法。 这些淋巴样细胞可用于提供具有确定的MHC限制的抗原特异性T细胞受体并鉴定免疫相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。
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公开(公告)号：EP2920209A1
公开(公告)日：2015-09-23
申请号：EP13789492.9
申请日：2013-11-12
申请人： BioNTech AG , Ganymed Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , STADLER, Christiane , HOLLAND, Julia , BÄHR-MAHMUD, Hayat , BEISSERT, Tim , PLUM, Laura , LE GALL, Fabrice , JENDRETZKI, Arne , FIEDLER, Markus
IPC分类号： C07K16/28
摘要： The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor- associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.
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公开(公告)号：EP3027208B1
公开(公告)日：2020-06-24
申请号：EP14750331.2
申请日：2014-07-30
申请人： Biontech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , G01N33/50
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公开(公告)号：EP2494037B1
公开(公告)日：2015-02-11
申请号：EP10773585.4
申请日：2010-10-29
IPC分类号： C12N5/0781 , C07K14/705 , C07K16/00 , C07K16/46 , C12N15/62
CPC分类号： C07K14/70578 , C07K16/00 , C07K2319/30 , C12N5/0635
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5.发明授权VERWENDUNG VON FLT3-LIGAND ZUR VERSTÄRKUNG VON IMMUNREAKTIONEN BEI RNA-IMMUNISIERUNG 有权使用FLT3配体改善RNA免疫中的免疫反应
公开(公告)号：EP2370101B1
公开(公告)日：2013-03-27
申请号：EP09796949.7
申请日：2009-12-09
IPC分类号： A61K39/39 , C07K14/475
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/475 , C07K2319/00
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6.发明公开TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEINS 有权TUMORIMFPUNG麻醉师EINER HUMORALEN免疫GEGEN SELBSTPROTEINE
公开(公告)号：EP2547695A1
公开(公告)日：2013-01-23
申请号：EP11707355.1
申请日：2011-03-09
发明人： KLAMP, Thorsten , SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HILLER, Thomas , SCHUMACHER, Jens
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
摘要翻译： 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者中针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。
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7.发明公开VERWENDUNG VON FLT3-LIGAND ZUR VERSTÄRKUNG VON IMMUNREAKTIONEN BEI RNA-IMMUNISIERUNG 有权FLT3配体对增强免疫反应RNA免疫的使用
公开(公告)号：EP2370101A1
公开(公告)日：2011-10-05
申请号：EP09796949.7
申请日：2009-12-09
IPC分类号： A61K39/39 , C07K14/475
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/475 , C07K2319/00
摘要： The invention relates to supplying vaccine RNA to cells. The invention relates in particular to a common use of vaccine RNA and Flt3 ligand for inducing, creating or enhancing an immune response when administered to animals (including humans).
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公开(公告)号：EP3738611A1
公开(公告)日：2020-11-18
申请号：EP20180951.4
申请日：2014-07-30
申请人： BioNTech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , G01N33/50 , G01N33/569 , G01N33/574
摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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公开(公告)号：EP2069538B1
公开(公告)日：2015-07-08
申请号：EP07818850.5
申请日：2007-10-09
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K39/39558 , A61K47/6807 , C07K16/28 , C07K16/2866 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N15/8218 , C12N2310/11 , C12N2310/14 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , G01N33/57484 , G01N33/57492 , G01N2333/715 , G01N2333/7158 , G01N2333/916
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10.发明授权VERWENDUNG VON FLT3-LIGAND ZUR VERSTÄRKUNG VON IMMUNREAKTIONEN BEI RNA-IMMUNISIERUNG 有权FLT3配体对增强免疫反应RNA免疫的使用
公开(公告)号：EP2370101B8
公开(公告)日：2013-05-01
申请号：EP09796949.7
申请日：2009-12-09
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/39 , C07K14/475
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/475 , C07K2319/00
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