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公开(公告)号：EP2994159A1
公开(公告)日：2016-03-16
申请号：EP14722117.0
申请日：2014-05-07
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TADMOR, Arbel David , CASTLE, John Christopher , BOEGEL, Sebastian , LÖWER, Martin
CPC分类号： G06F19/18 , A61K39/0011 , C12Q1/6886 , C12Q2600/156
摘要： The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and. thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP2714071A2
公开(公告)日：2014-04-09
申请号：EP12723117.3
申请日：2012-05-23
申请人： Biontech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , DIEKMANN, Jan , KOSLOWSKI, Michael , BRITTEN, Cedrik , CASTLE, John , LÖWER, Martin , RENARD, Bernhard , OMOKOKO, Tana , DE GRAAF, Johannes Hendrikus
CPC分类号： A61K39/0011 , C12Q1/6886 , C12Q2600/156 , G16B20/00 , G16B40/00
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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公开(公告)号：EP3792628A3
公开(公告)日：2021-05-19
申请号：EP20193183.9
申请日：2017-05-10
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
摘要： The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP2714071B1
公开(公告)日：2019-07-10
申请号：EP12723117.3
申请日：2012-05-23
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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公开(公告)号：EP3473267A1
公开(公告)日：2019-04-24
申请号：EP18199105.0
申请日：2012-05-23
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , DIEKMANN, Jan , KOSLOWSKI, Michael , BRITTEN, Cedrik , CASTLE, John , LÖWER, Martin , RENARD, Bernhard , OMOKOKO, Tana , DE GRAAF, Johannes Hendrikus
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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6.发明公开
公开(公告)号：EP3455625A1
公开(公告)日：2019-03-20
申请号：EP17726208.6
申请日：2017-05-10
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
摘要： The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP4223311A1
公开(公告)日：2023-08-09
申请号：EP23169466.2
申请日：2012-05-23
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , DIEKMANN, Jan , KOSLOWSKI, Michael , BRITTEN, Cedrik , CASTLE, John , LÖWER, Martin , RENARD, Bernhard , OMOKOKO, Tana , DE GRAAF, Johannes Hendrikus
IPC分类号： A61K39/00 , C12Q1/68 , A61P35/00 , G01N33/50 , C12Q1/6886 , G16B20/00 , G16B20/20 , G16B20/40 , G16B20/50 , G16B40/00
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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公开(公告)号：EP3895727A1
公开(公告)日：2021-10-20
申请号：EP21159558.2
申请日：2014-05-07
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TADMOR, Arbel David , CASTLE, John Christopher , BOEGEL, Sebastian , LÖWER, Martin
摘要： The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3892295A1
公开(公告)日：2021-10-13
申请号：EP21168360.2
申请日：2012-05-23
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , DIEKMANN, Jan , KOSLOWSKI, Michael , BRITTEN, Cedrik , CASTLE, John , LÖWER, Martin , RENARD, Bernhard , OMOKOKO, Tana , DE GRAAF, Johannes Hendrikus
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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公开(公告)号：EP3635129A1
公开(公告)日：2020-04-15
申请号：EP18727021.0
申请日：2018-06-01
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , SUCHAN, Martin , SCHRÖRS, Barbara , LÖWER, Martin , OEHM, Petra
IPC分类号： C12Q1/68
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