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1.发明公开
公开(公告)号：EP3058059A2
公开(公告)日：2016-08-24
申请号：EP14854424.0
申请日：2014-10-17
申请人： Biopetrolia AB
发明人： NIELSEN, Jens , SIEWERS, Verena , KRIVORUCHKO, Anastasia , ZHANG, Yiming , ZHOU, Yongjin , BUIJS, Nicolaas A. A. , DAI, Zongjie
CPC分类号： C12N15/52 , C12N9/0008 , C12N9/0051 , C12N9/1025 , C12N9/1029 , C12N9/13 , C12N9/88 , C12N9/93 , C12P5/00 , C12P7/00 , C12Y102/04001 , C12Y102/07001 , C12Y208/01008 , C12Y401/01001 , C12Y603/01
摘要： The invention relates to engineering of acetyl-CoA metabolism in yeast and in particular to production of acetyl-CoA in a non-ethanol producing yeast lacking endogenous gene(s) encoding pyruvate decarboxylase and comprising a heterologous pathway for synthesis of cytosolic acetyl-CoA.
摘要翻译： 本发明涉及在酵母中乙酰辅酶A代谢的工程，特别是在缺乏编码丙酮酸脱羧酶的内源基因的非乙醇生产酵母中产生乙酰辅酶A，并且包含用于合成细胞溶质乙酰辅酶A的异源途径。
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公开(公告)号：EP3382015A1
公开(公告)日：2018-10-03
申请号：EP18167295.7
申请日：2011-08-05
申请人： Biopetrolia AB
发明人： NIELSEN, Jens , SHI, Shuobo
CPC分类号： C12P7/649 , C12N9/1029 , C12N15/81 , Y02E50/13
摘要： The present invention relates to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing different fatty acids and specifically fatty acid ethyl esters (FAEE), the main components of biodiesel. An increased in fatty acid production, and hence in FAEE, is obtained in the first place by expressing different heterologous polypeptides in combination with the down-regulation, attenuation, deletion or over-expression of specially selected genes, wherein said genes encode enzymes involved in the fatty acids synthesizing pathway, fatty acid consuming pathways, carbohydrate biosynthesis pathways or enzyme acting as wax ester transporters or a combination thereof. The methods and products of the invention would allow large-scale production of FAEE with carbohydrates as the only externally-supplied substrate.
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公开(公告)号：EP3058078A1
公开(公告)日：2016-08-24
申请号：EP14853593.3
申请日：2014-10-17
申请人： Biopetrolia AB
发明人： NIELSEN, Jens , SIEWERS, Verena , GONCALVES TEIXEIRA, Paulo Alexandre , ZHOU, Yongjin , BUIJS, Nicolaas A. A. , DAVID, Florian
CPC分类号： C12N15/81 , C12N9/0008 , C12N9/0042 , C12N9/0069 , C12N9/0095 , C12N9/1029 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12Y102/01042
摘要： The present invention relates to the development of genetically engineered yeasts that can produce hydrocarbons in a controllable and economic fashion. More specifically the invention relates to the production of liquid alkanes and alkenes that can be used for liquid transportation fuels, specialty chemicals, or feed stock for further chemical conversion.
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公开(公告)号：EP3058078B1
公开(公告)日：2019-10-09
申请号：EP14853593.3
申请日：2014-10-17
申请人： Biopetrolia AB
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5.发明公开FUNGAL CELLS AND METHODS FOR PRODUCTION OF VERY LONG CHAIN FATTY ACID DERIVED PRODUCTS 审中-公开用于生产非常长链脂肪酸衍生产品的真菌细胞和方法
公开(公告)号：EP3277827A1
公开(公告)日：2018-02-07
申请号：EP16717489.5
申请日：2016-04-01
申请人： Biopetrolia AB
发明人： DAVID, Florian , SIEWERS, Verena , KRIVORUCHKO, Anastasia , WENNING, Leonie , YU, Tao , ZHOU, Yong-Jin , NIELSEN, Jens
IPC分类号： C12P7/64
CPC分类号： C12P7/6409 , C12N9/0008 , C12N9/1029 , C12P7/04 , C12P7/6463 , C12Y102/0105 , C12Y203/01075
摘要： The present invention generally relates to a genetically modified fungal cell capable of producing a very long, chain fatty acid (VLCFA) and/or a VLCFA derivative. The genetically modified fungal cell comprises at least one exogenous gene encoding a fatty acyl-CoA reductase, and at least one gene encoding an elongase, and/or at least one gene encoding a fatty acid synthase.
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公开(公告)号：EP3268468A1
公开(公告)日：2018-01-17
申请号：EP16714581.2
申请日：2016-03-10
申请人： Biopetrolia AB
发明人： QIN, Jiufu , KRIVORUCHKO, Anastasia , DAVID, Florian , JIANG, Bo , NIELSEN, Jens
CPC分类号： C12P13/10 , C12N9/0008 , C12N9/1018 , C12N9/1096 , C12N9/1217 , C12N9/78 , C12N9/88 , C12N15/52 , C12P13/001 , C12Y102/01038 , C12Y201/03003 , C12Y206/01011 , C12Y207/02008 , C12Y305/03001 , C12Y401/01017 , C12Y403/02001
摘要： The present invention relates to the provision of genetically modified microbial cells, such as yeast cells with an improved ability for producing L-ornithine and its derivatives. Overproduction of L-ornithine is obtained in the first place by the down-regulation or attenuation of specially selected genes, wherein said genes encode enzymes involved in the L-ornithine consumption and/or degradation pathways. Further L-ornithine production ability is improved by down-regulation, attenuation, deletion or overexpression of specially selected genes, wherein said genes encode enzymes and/or proteins involved in the L-ornithine ‘acetylated derivatives cycle’, L-glutamate synthesis pathways, subcellular trafficking, TCA cycle, pyruvate carboxylation pathway, respiratory electron-transport chain, and the carbon substrates' assimilation machinery. The invention additionally provides a method to produce L-ornithine with said modified eukaryotic cells.
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