公开(公告)号：EP2977443A4

公开(公告)日：2016-09-07

申请号：EP14768563

申请日：2014-02-25

申请人： CJ CHEILJEDANG CORP

发明人： LEE KYOUNG MIN ,  JUNG HEE KYOUNG ,  YANG YOUNG LYEOL ,  UM HYE WON ,  KIM CHANG GYEOM ,  LI HONG XIAN ,  PARK SU JIN ,  YOON JONG HYUN ,  LEE BAEK SEOK ,  LEE SUN YOUNG

IPC分类号： C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/00

CPC分类号： C12P13/001 ,  C12N9/0008 ,  C12N9/1018 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1217 ,  C12N9/88 ,  C12N15/52 ,  C12Y102/01038 ,  C12Y201/03003 ,  C12Y203/01035 ,  C12Y206/01011 ,  C12Y207/02008 ,  C12Y401/01007

摘要： The present invention relates to a recombinant microorganism capable of producing putrescine, in which the microorganism is modified to have enhanced NCgl2522 activity, thereby producing putrescine in a high yield, and a method for producing putrescine using the microorganism.

摘要翻译： 本发明涉及一种能够生产腐胺，其中所述微生物被修饰以具有增强的NCgl2522的活性，从而生产腐胺以高收率的重组微生物，以及使用该微生物生产腐胺的方法。

公开(公告)号：EP3318629A1

公开(公告)日：2018-05-09

申请号：EP16818137.8

申请日：2016-06-03

申请人： CJ Cheiljedang Corp.

发明人： LEE, Jae Hun ,  YANG, Young Lyeol ,  OH, In Seok

IPC分类号： C12N9/10 ,  C12N15/52 ,  C12N15/70 ,  C12P13/00

CPC分类号： C12N9/1096 ,  C12N15/52 ,  C12N15/70 ,  C12P13/00 ,  C12Y206/01011

摘要： Provided are a novel separated polypeptide having transaminase activity, a polynucleotide encoding the polypeptide, a microorganism including the polynucleotide, and a method of deaminating an amino compound by using the polypeptide or the microorganism.

摘要翻译： 提供了具有转氨酶活性的新型分离多肽，编码该多肽的多核苷酸，包含该多核苷酸的微生物，以及使用该多肽或微生物使氨基化合物脱氨的方法。

公开(公告)号：EP3268468A1

公开(公告)日：2018-01-17

申请号：EP16714581.2

申请日：2016-03-10

申请人： Biopetrolia AB

发明人： QIN, Jiufu ,  KRIVORUCHKO, Anastasia ,  DAVID, Florian ,  JIANG, Bo ,  NIELSEN, Jens

IPC分类号： C12N9/10 ,  C12N15/52 ,  C12P13/00 ,  C12P13/10

CPC分类号： C12P13/10 ,  C12N9/0008 ,  C12N9/1018 ,  C12N9/1096 ,  C12N9/1217 ,  C12N9/78 ,  C12N9/88 ,  C12N15/52 ,  C12P13/001 ,  C12Y102/01038 ,  C12Y201/03003 ,  C12Y206/01011 ,  C12Y207/02008 ,  C12Y305/03001 ,  C12Y401/01017 ,  C12Y403/02001

摘要： The present invention relates to the provision of genetically modified microbial cells, such as yeast cells with an improved ability for producing L-ornithine and its derivatives. Overproduction of L-ornithine is obtained in the first place by the down-regulation or attenuation of specially selected genes, wherein said genes encode enzymes involved in the L-ornithine consumption and/or degradation pathways. Further L-ornithine production ability is improved by down-regulation, attenuation, deletion or overexpression of specially selected genes, wherein said genes encode enzymes and/or proteins involved in the L-ornithine ‘acetylated derivatives cycle’, L-glutamate synthesis pathways, subcellular trafficking, TCA cycle, pyruvate carboxylation pathway, respiratory electron-transport chain, and the carbon substrates' assimilation machinery. The invention additionally provides a method to produce L-ornithine with said modified eukaryotic cells.