-
1.发明公开
公开(公告)号：EP1711480A1
公开(公告)日：2006-10-18
申请号：EP05700863.3
申请日：2005-01-13
发明人： HOENKE, Christoph , RUDOLF, Klaus , BOUYSSOU, Thierry , KONETZKI, Ingo , LUSTENBERGER, Philipp , MACK, Jürgen , SCHNAPP, Andreas , WIEDENMAYER, Dieter
IPC分类号： C07D265/36 , C07D413/12 , A61K31/538 , A61P11/08
CPC分类号： C07D265/36 , C07D413/12
摘要： The invention relates to compounds of formula (1), wherein groups X, Ra, Rb, R1, R1', R2, R2', R2'', R2''', V and n can have the meanings as cited in the claims and in the description, and to the use of these compounds as medicaments, particularly for treating inflammatory and obstructive respiratory diseases.
-
2.发明授权USE OF BIBN4096 IN COMBINATION WITH OTHER ANTIMIGRAINE DRUGS FOR THE TREATMENT OF MIGRAINE 有权BIBN4096的与其他基金中的联合应用治疗偏头痛偏头痛的治疗
公开(公告)号：EP1420790B1
公开(公告)日：2005-09-21
申请号：EP02794772.0
申请日：2002-08-10
发明人： DOODS, Henri , RUDOLF, Klaus , EBERLEIN, Wolfgang
IPC分类号： A61K31/517 , A61K31/422 , A61K31/4045 , A61K31/48 , A61P29/00 , A61P25/06
CPC分类号： A61K31/422 , A61K31/4045 , A61K31/48 , A61K31/517 , A61K2300/00
摘要： The present invention relates to a method of treatment or prevention of headache, migraine or cluster headaches, which method comprises co-administration of a therapeutically effective amount of the compound A = 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1 H)-oxochinazolin-3-yl)-1-piperidinyl]-carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine [BIBN4096BS] or a physiologically acceptable salt thereof and a therapeutically effective amount of a second active antimigraine drug, particularly sumatriptan, zolmitriptan or dihydroergotamin or a physiologically acceptable salt thereof, as well as to the corresponding pharmaceutical compositions and the preparation thereof.
-
3.发明公开BENZODIAZEPIN-SUBSTITUIERTE PIPERDINE ZUR VERWENDUNG IN DER BEHANDLUNG VON CARDIOVASKULÄREN ERKRANKUNGEN 有权苯二氮取代哌啶用以进行血管疾病CARDIO的治疗
公开(公告)号：EP1487821A1
公开(公告)日：2004-12-22
申请号：EP03708202.1
申请日：2003-03-10
发明人： HURNAUS, Rudolf , RUDOLF, Klaus , MÜLLER, Stephan, Georg , STENKAMP, Dirk , LUSTENBERGER, Philipp , DREYER, Alexander , GERLACH, Kai , SCHINDLER, Marcus , ARNDT, Kirsten , BAUER, Eckhart
IPC分类号： C07D401/14 , C07D471/04 , A61K31/5513 , A61P3/10
CPC分类号： C07D401/14 , C07D471/04
摘要： The invention relates to substituted piperidines of general formula (I), wherein R, R2 to R5, A, X, Z and n have the meaning defined in claim 1, to their tautomers, their diastereomers, their enantiomers, their mixtures and salts, especially their physiologically acceptable salts with inorganic or organic acids or bases. Said piperidines have valuable pharmacological properties, particularly CGRP-antagonistic properties. The invention also relates to medicaments containing said compounds, to the use thereof and to a method for the production of said compounds.
-
4.发明授权VERWENDUNG VON CGRP-ANTAGONISTEN UND CGRP-RELEASE-HEMMERN ZUR BEKÄMPFUNG MENOPAUSALER HITZEWALLUNGEN 有权CGRP拮抗剂和CGRP释放抑制剂的利用互联网打击更年期潮热
公开(公告)号：EP1207884B1
公开(公告)日：2004-11-03
申请号：EP00958385.7
申请日：2000-08-05
IPC分类号： A61K31/495 , A61K31/445 , A61K31/505 , A61K31/55 , A61K31/54 , A61P15/12
CPC分类号： A61K31/551 , A61K31/00 , A61K31/445 , A61K31/496 , A61K31/513 , A61K31/517 , A61K31/5415
摘要： The invention relates to the use of CGRP antagonists and CGRP release inhibitors for controlling menopausal hot flashes, to corresponding medicaments containing, as an active substance, one or more CGRP antagonists and/or CGRP release inhibitors, and to the production thereof.
-
5.发明公开USE OF BIBN4096 IN COMBINATION WITH OTHER ANTIMIGRAINE DRUGS FOR THE TREATMENT OF MIGRAINE 有权BIBN4096的与其他基金中的联合应用治疗偏头痛偏头痛的治疗
公开(公告)号：EP1420790A1
公开(公告)日：2004-05-26
申请号：EP02794772.0
申请日：2002-08-10
发明人： DOODS, Henri , RUDOLF, Klaus , EBERLEIN, Wolfgang
IPC分类号： A61K31/517 , A61K31/422 , A61K31/4045 , A61K31/48 , A61P29/00 , A61P25/06
CPC分类号： A61K31/422 , A61K31/4045 , A61K31/48 , A61K31/517 , A61K2300/00
摘要： The present invention relates to a method of treatment or prevention of headache, migraine or cluster headaches, which method comprises co-administration of a therapeutically effective amount of the compound A = 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1 H)-oxochinazolin-3-yl)-1-piperidinyl]-carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine [BIBN4096BS] or a physiologically acceptable salt thereof and a therapeutically effective amount of a second active antimigraine drug, particularly sumatriptan, zolmitriptan or dihydroergotamin or a physiologically acceptable salt thereof, as well as to the corresponding pharmaceutical compositions and the preparation thereof.
-
6.发明授权ABGEWANDELTE AMINOSÄUREN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZU IHRER HERSTELLUNG 失效修饰的氨基酸，药物含有它们的工艺FOR THEIR
公开(公告)号：EP0927192B1
公开(公告)日：2004-05-12
申请号：EP97938928.5
申请日：1997-09-08
发明人： RUDOLF, Klaus , EBERLEIN, Wolfgang , ENGEL, Wolfhard , PIEPER, Helmut , DOODS, Henri , HALLERMAYER, Gerhard , ENTZEROTH, Michael , WIENEN, Wolfgang
IPC分类号： C07K5/06 , C07D401/12 , C07D409/12 , C07D417/12 , C07D419/12
CPC分类号： G01N33/9406 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/549 , A61K38/00 , C07K5/06078 , C07K5/06191 , Y02P20/55
-
7.发明公开
公开(公告)号：EP1562603A2
公开(公告)日：2005-08-17
申请号：EP03778312.3
申请日：2003-11-11
发明人： BOUYSSOU, Thierry , BUETTNER, Frank , KONETZKI, Ingo , PESTEL, Sabine , SCHNAPP, Andreas , SCHOLLENBERGER, Hermann , SCHROMM, Kurt , HEINE, Claudia , RUDOLF, Klaus , LUSTENBERGER, Philipp , HOENKE, Christoph
IPC分类号： A61K31/538 , A61P11/00 , A61K31/535
CPC分类号： A61K31/538 , C07D265/36
摘要： The invention relates to the use of compounds of general formula (I), where the groups R1, R2 and R3 can have the meanings as given in the claims and description, for the production of a medicament for the treatment of COPD (Chronic Obstructive Pulmonary Disease) and novel compounds of general formula (I) as such.
-
8.发明授权
公开(公告)号：EP1711480B1
公开(公告)日：2007-12-19
申请号：EP05700863.3
申请日：2005-01-13
发明人： HOENKE, Christoph , RUDOLF, Klaus , BOUYSSOU, Thierry , KONETZKI, Ingo , LUSTENBERGER, Philipp , MACK, Jürgen , SCHNAPP, Andreas , WIEDENMAYER, Dieter
IPC分类号： C07D265/36 , C07D413/12 , A61K31/538 , A61P11/08
CPC分类号： C07D265/36 , C07D413/12
摘要： The invention relates to compounds of formula (1), wherein groups X, Ra, Rb, R1, R1', R2, R2', R2'', R2''', V and n can have the meanings as cited in the claims and in the description, and to the use of these compounds as medicaments, particularly for treating inflammatory and obstructive respiratory diseases.
-
9.发明授权BENZODIAZEPIN-SUBSTITUIERTE PIPERDINE ZUR VERWENDUNG IN DER BEHANDLUNG VON CARDIOVASKULÄREN ERKRANKUNGEN 有权苯二氮取代哌啶用以进行血管疾病CARDIO的治疗
公开(公告)号：EP1487821B1
公开(公告)日：2007-03-21
申请号：EP03708202.1
申请日：2003-03-10
发明人： HURNAUS, Rudolf , RUDOLF, Klaus , MÜLLER, Stephan, Georg , STENKAMP, Dirk , LUSTENBERGER, Philipp , DREYER, Alexander , GERLACH, Kai , SCHINDLER, Marcus , ARNDT, Kirsten , BAUER, Eckhart
IPC分类号： C07D401/14 , C07D471/04 , A61K31/5513 , A61P3/10
CPC分类号： C07D401/14 , C07D471/04
摘要： The invention relates to substituted piperidines of general formula (I), wherein R, R2 to R5, A, X, Z and n have the meaning defined in claim 1, to their tautomers, their diastereomers, their enantiomers, their mixtures and salts, especially their physiologically acceptable salts with inorganic or organic acids or bases. Said piperidines have valuable pharmacological properties, particularly CGRP-antagonistic properties. The invention also relates to medicaments containing said compounds, to the use thereof and to a method for the production of said compounds.
-
公开(公告)号：EP1163239B1
公开(公告)日：2003-05-28
申请号：EP00922505.3
申请日：2000-03-08
IPC分类号： C07D401/14 , C07D471/04 , G01N33/58 , A61K31/513 , A61K31/4178 , A61K31/551 , A61K31/4196 , A61P9/00 , A61P3/10
CPC分类号： C07D401/04 , A61K38/00 , C07D211/58 , C07D401/14 , C07D471/04 , C07K5/06078
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.033 秒)
