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1.发明公开COMBINATION OF C1-INH AND LUNG SURFACTANT FOR THE TREATMENT OF RESPIRATORY DISORDERS 审中-公开C1-INH组合以及治疗RESPIRATIONSTÖRUNGEN肺
公开(公告)号：EP1216052A1
公开(公告)日：2002-06-26
申请号：EP99947362.2
申请日：1999-09-16
申请人： Byk Gulden Lomberg Chemische Fabrik GmbH , Aventis Behring GmbH , Vangerow, Burkhard , Rückoldt, Horst , Marx, Gernot , Cobas Meyer, Michael , Leuwer, Martin
发明人： VANGEROW, Burkhard , RÜCKOLDT, Horst , MARX, Gernot , COBAS MEYER, Michael , LEUWER, Martin , HÄFNER, Dietrich , GERMANN, Paul-Georg , OTT, Nils
IPC分类号： A61K38/57 , A61K31/685 , A61K35/42 , A61K45/06 , A61P11/00
CPC分类号： A61K45/06 , A61K9/0082 , A61K31/66 , A61K38/02 , A61K38/57 , Y10T436/104165 , A61K2300/00
摘要： Pharmaceutical composition for the treatment of IRDS and ALI (including ARDS) which contains C1-INH (C1 esterase inhibitor) and lung surfactant.
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公开(公告)号：EP1192184A1
公开(公告)日：2002-04-03
申请号：EP00935162.8
申请日：2000-06-02
IPC分类号： C07K14/785 , A61K38/17 , A61P11/00
CPC分类号： C07K14/785 , A61K38/00
摘要： Novel surfactant protein C esters suitable for preparing pharmaceutical compositions for the treatment of infant respiratory distress syndrome and adult respiratory distress syndrome are described.
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公开(公告)号：EP1070056A1
公开(公告)日：2001-01-24
申请号：EP99914474.4
申请日：1999-03-04
发明人： HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , BEUME, Rolf , KLEY, Hans-Peter , VAN DER LAAN, Ivonne, Johanna , TIMMERMAN, Hendrik , STERK, Geert, Jan , VAN DER MEY, Margaretha
IPC分类号： C07D237/32 , A61K31/50 , C07D417/12 , A61K31/54
CPC分类号： C07D237/32 , C07D417/12
摘要： The compounds of formula (I) in which R1, R2, R3, R4, R5, X and Y have the meanings as given in the description are novel effective bronchial therapeutica.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，X和Y具有如在说明书中给出的含义的式（I）化合物是新型有效的支气管疗法。
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公开(公告)号：EP0772610B1
公开(公告)日：2000-10-04
申请号：EP95926953.1
申请日：1995-07-19
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , GUTTERER, Beate , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter , ULRICH, Wolf-Rüdiger , THIBAUT, Ulrich
IPC分类号： C07D401/12 , C07D307/94 , C07D307/79 , A61K31/34 , A61K31/44
CPC分类号： C07D307/79 , C07D307/94 , C07D405/12 , C07D493/10
摘要： The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. These compounds are novel, effective PDE-inhibitors.
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公开(公告)号：EP0988302A1
公开(公告)日：2000-03-29
申请号：EP98930737.6
申请日：1998-05-27
发明人： GUTTERER, Beate , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , BÄR, Thomas , MARTIN, Thomas , KILIAN, Ulrich , ELTZE, Manfrid , BRAND, Ursula , BOSS, Hildegard , KLEY, Hans-Peter , SCHUDT, Christian , GOEBEL, Karl-Josef , FLOCKERZI, Dieter , HATZELMANN, Armin
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： The invention concerns the compounds 8,9-Diethoxy-2-methyl-6- [4(p-toluenesulfonamido)phenyl] -1,2,3,4,4a,10b-hexahydrobenzo[c] [1,6]naphthyridine and 9-Ethoxy-8-methoxy-2- methyl-6-[4-(p-toluenesulfonamido) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo [c][1,6]naphthyridine and their therapeutic application.
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公开(公告)号：EP0968211A1
公开(公告)日：2000-01-05
申请号：EP98913621.3
申请日：1998-03-03
发明人： GUTTERER, Beate , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger , MARTIN, Thomas , BÄR, Thomas , HUMMEL, Rolf-Peter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KLEY, Hans-Peter , HÄFNER, Dietrich , GOEBEL, Karl-Josef , FLOCKERZI, Dieter
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which R4 is a phenyl radical substituted by R5, where R5 is a tetrazole-5-yl radical optionally substituted by a radical R6, are novel efficacious PDE3/4 inhibitors.
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公开(公告)号：EP0923568A1
公开(公告)日：1999-06-23
申请号：EP97942858.0
申请日：1997-08-13
发明人： ULRICH, Wolf-Rüdiger , FLOCKERZI, Dieter , GUTTERER, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter , AMSCHLER, Hermann
CPC分类号： C07D307/79 , C07D405/12
摘要： Compounds of formula (I) in which R1 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine, R2 is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, Ar is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where R3 is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino, R4 is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy, R5 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R6 is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino, R7 is hydrogen, halogen, amino or 1-4C-alkyl, R8 is hydrogen or halogen and R9 is hydrogen or halogen, the salts of this compound, and the N-oxides of the pyridines and their salts are active bronchial therapeutics.
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公开(公告)号：EP0553174B1
公开(公告)日：1998-07-08
申请号：EP91918141.2
申请日：1991-10-12
发明人： AMSCHLER, Hermann , FIGALA, Volker , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BEUME, Rolf , HÄFNER, Dietrich , HANAUER, Guido , ELTZE, Manfrid , SCHUDT, Christian , KILIAN, Ulrich
IPC分类号： C07D237/14 , A61K31/50
CPC分类号： C07D237/14
摘要： Disclosed are new compounds of general formula (I), in which one of the substituents R1 and R2 is a methoxy, difluoromethoxy or ethoxy group and the other is a C4-C7 cycloalkoxy or C3-C7 cycloalkylmethoxy group, as well as the salts formed by these compounds with bases. The compounds are suitable for use as active ingredients in bronchospasmolytics.
摘要翻译： 公开了通式（I）的新化合物，其中取代基R1和R2之一是甲氧基，二氟甲氧基或乙氧基，另一个是C4-C7环烷氧基或C3-C7环烷基甲氧基，以及形成的盐 通过这些化合物与碱。 这些化合物适合用作支气管痉挛剂中的活性成分。
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公开(公告)号：EP1131055A1
公开(公告)日：2001-09-12
申请号：EP99971701.0
申请日：1999-11-09
CPC分类号： A61K38/1709 , A61K9/0082
摘要： The invention describes a set for the treatment of IRDS, ALI or ARDS, comprising a first container which has a volume of 50 to 500 ml and contains a pulverulent pulmonary surfactant preparation, the amount of phospholipids in the container being 50 to 500 mg, and a second container which has a volume of 50 to 500 ml and contains a pulverulent pulmonary surfactant preparation, where the amount of phospholipids in the second container is 1 to 10 g.
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10.发明公开COMPOSITIONS COMPRISING PHENYLAMINOTHIOPHENACETIC ACID DERIVATIVES FOR THE TREATMENT OF ACUTE OR ADULT RESPIRATORY DISTRESS SYNDROME (ARDS) AND INFANT RESPIRATORY DISTRESS SYNDROME (IRDS) 有权制备含PHENYLAMINOTHIOPHENESSIGSÄURE的衍生物对急性呼吸功能不全（ARDS）和急性呼吸功能不全IN儿童的治疗（IRDS）
公开(公告)号：EP1098645A1
公开(公告)日：2001-05-16
申请号：EP99931116.0
申请日：1999-06-19
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt of this compound and lung surfactant.
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