公开(公告)号：EP2001517A2

公开(公告)日：2008-12-17

申请号：EP07754113.4

申请日：2007-03-29

申请人： Cell Genesys Inc. ,  ARIAD PHARMACEUTICALS, INC.

发明人： HARDING, Thomas, C. ,  FANG, Jianmin ,  RIVERA, Victor, M. ,  MINH, Nguyen ,  CLACKSON, Timothy, P. ,  JOOSS, Karin

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/86 ,  A61K48/0066 ,  C07K14/005 ,  C07K16/2863 ,  C07K2319/50 ,  C12N2750/14143 ,  C12N2770/32122 ,  C12N2830/002

摘要： Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing cleavage site between the coding sequence for the first and second immunoglobulin coding sequence and a additional proteolytic cleavage site, which provides a means to remove the self processing peptide sequenc from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.

公开(公告)号：EP1629095A2

公开(公告)日：2006-03-01

申请号：EP04785714.9

申请日：2004-04-26

申请人： CELL GENESYS, INC.

发明人： FANG, Jianmin ,  JOOSS, Karin ,  QIAN, Jing-Jing

IPC分类号： C12N15/00 ,  C12N15/64 ,  C12N15/63 ,  C12N15/86 ,  C12P21/06 ,  C07H21/00

CPC分类号： C07K16/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/50 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2800/60 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/42 ,  C12N2830/48 ,  C12N2830/85 ,  C12N2830/90 ,  C12N2840/203

摘要： Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in methods for enhanced production of biologically active immunoglobulins or fragments thereof in vitro or in vivo.

公开(公告)号：EP1765846A2

公开(公告)日：2007-03-28

申请号：EP05770729.1

申请日：2005-07-13

申请人： CELL GENESYS, INC.

发明人： FANG, Jianmin ,  JOOSS, Karin

IPC分类号： C07H21/04 ,  A01N43/04 ,  C12N5/06

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K16/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/74 ,  C12N2750/14132 ,  C12N2750/14143

摘要： Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.

公开(公告)号：EP2132324A2

公开(公告)日：2009-12-16

申请号：EP08726345.5

申请日：2008-03-03

申请人： Cell Genesys Inc.

发明人： JOOSS, Karin ,  HARDING, Thomas ,  NGUYEN, Minh ,  KOPRIVNIKAR, Kathryn, E.

IPC分类号： C12Q1/00 ,  G01N33/567 ,  G01N33/574

CPC分类号： G01N33/57434 ,  G01N33/6863 ,  G01N2333/535

摘要： The present invention relates to prostate cancer markers, compositions comprising such markers, immunoglobulins specific for such markers, and methods of using such markers and/or immunoglobulins to assess an immune response against prostate cancer. An immune response against the markers correlates with an immune response, in particular a humoral immune response, against prostate cancer cells which immune response is preferably associated with prophylaxis of prostate cancer, treatment of prostate cancer, and/or amelioration of at least one symptom associated with prostate cancer.

公开(公告)号：EP2002263A2

公开(公告)日：2008-12-17

申请号：EP07754126.6

申请日：2007-03-29

申请人： Cell Genesys Inc. ,  The Regents of the University of California

发明人： SIMMONS, Andrew ,  JOOSS, Karin ,  ALLISON, James

IPC分类号： G01N33/574

CPC分类号： A61K39/0011 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  A61K2039/55516 ,  A61K2039/55522 ,  C07K16/2818

摘要： Cellular compositions and methods for inducing an immune response to tumor cells are described. The cellular compositions include a tumor antigen and cells that have been modified to express a cytokine and one or more of a tumor antigen, an anti-CTLA4 antibody and an additional cytokine. The cellular compositions find utility in methods for treating cancer.

公开(公告)号：EP1636360A1

公开(公告)日：2006-03-22

申请号：EP04801855.0

申请日：2004-04-26

申请人： CELL GENESYS, INC.

发明人： FANG, Jianmin ,  JOOSS, Karin ,  SIMMONS, Andrew ,  QIAN, Jing-Jing

IPC分类号： C12N15/00 ,  C12N15/64 ,  C12N15/63 ,  C12N15/86 ,  C12P21/06 ,  C07H21/04 ,  C07K1/00

CPC分类号： C12N15/86 ,  C07K16/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/50 ,  C12N15/8273 ,  C12N2750/14143 ,  C12N2800/60 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/42 ,  C12N2830/48 ,  C12N2830/85 ,  C12N2830/90 ,  C12N2840/203

摘要： Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.

公开(公告)号：EP1915444A2

公开(公告)日：2008-04-30

申请号：EP06787791.0

申请日：2006-07-19

申请人： CELL GENESYS, INC.

发明人： FANG, Jianmin ,  JOOSS, Karin ,  SIMMONS, Andrew, D. ,  FARSON, Deborah, A. ,  QIAN, Jing Jing

IPC分类号： C12N15/00 ,  C12N5/06 ,  C12N15/64

CPC分类号： C12N15/86 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/76 ,  C12N2510/02 ,  C12N2740/15043

摘要： Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.

公开(公告)号：EP1437938A2

公开(公告)日：2004-07-21

申请号：EP02725849.0

申请日：2002-04-29

申请人： CELL GENESYS, INC.

发明人： CHANG, Betty ,  WU, Wei Wei ,  MACARTHUR, James ,  PATEL, Salil ,  JOOSS, Karin ,  MENDEZ, Michael

IPC分类号： A01N43/04 ,  A61K31/70 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74

CPC分类号： C12N9/6435 ,  A61K48/00 ,  C07K14/78 ,  C12N2799/022 ,  C12N2799/025 ,  C12Y304/21007

摘要： The present invention provides anti-angiogenic compositions and methods, based on gene delivery vectors that include the coding sequence for an anti-angiogenic compound.

公开(公告)号：EP2007896A2

公开(公告)日：2008-12-31

申请号：EP07754417.9

申请日：2007-03-28

申请人： Cell Genesys Inc.

发明人： LI, Betty ,  DU, Thomas ,  JOOSS, Karin

IPC分类号： C12P1/00

CPC分类号： A61K45/06 ,  A61K31/517 ,  A61K48/0083 ,  C07K14/535 ,  A61K2300/00

摘要： The present invention in all of its associated aspects provides improved methods and compositions for treating cancer in a mammal based on the sequential administration of the combination of a cytokine-expressing cancer immunotherapy composition and at least one tyrosine kinase inhibitor, wherein administration of the combination results in enhanced therapeutic efficacy relative to administration of the cytokine-expressing cancer immunotherapy composition or at least one tyrosine kinase inhibitor as a monotherapy.

公开(公告)号：EP1608321A2

公开(公告)日：2005-12-28

申请号：EP04759735.6

申请日：2004-03-24

申请人： CELL GENESYS, INC.

发明人： JOOSS, Karin ,  CRESON, Jennifer ,  LI, Betty ,  PRELL, Rodney ,  AUNG, Sandra ,  MOSKALENKO, Marina ,  DU, Thomas

IPC分类号： A61K7/00

CPC分类号： A61K39/0011 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/212 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K16/2818 ,  C07K16/2878 ,  A61K2300/00

摘要： The present invention in all of its associated aspects provides improved methods and compositions for treating cancer in a mammal based on the administration of the combination of a cytokine-expressing cellular vaccine and at least one additional cancer therapeutic agent or treatment to a patient with cancer, wherein administration of the combination results in enhanced therapeutic efficacy relative to administration of the cytokine-expressing cellular vaccine or cancer therapeutic agent or treatment as a monotherapy.