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公开(公告)号：EP1480687B1
公开(公告)日：2009-02-11
申请号：EP03717407.5
申请日：2003-02-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NANTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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公开(公告)号：EP1480687A1
公开(公告)日：2004-12-01
申请号：EP03717407.5
申请日：2003-02-18
申请人： Centre National de la Recherche Scientifique , Universite de Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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3.发明公开
公开(公告)号：EP2117612A1
公开(公告)日：2009-11-18
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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4.发明公开
公开(公告)号：EP3049462A1
公开(公告)日：2016-08-03
申请号：EP14789407.5
申请日：2014-09-25
申请人： IFSTTAR Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux , Algosource , Universite de Nantes , Centre National de la Recherche Scientifique , ONIRIS , Ecole Des Mines De Nantes
发明人： CHAILLEUX, Emmanuel , AUDO, Mariane , BUJOLI, Bruno , QUEFFELEC, Clémence , LEGRAND, Jack , PARASCHIV, Maria , TAZEROUT, Mohand , LEPINE, Olivier
IPC分类号： C08H99/00 , C09J199/00 , C08L99/00 , C04B26/00 , C04B26/28 , C04B18/24 , E01C7/00 , C08H8/00 , C09J191/00 , C08L91/00
CPC分类号： C08L99/00 , C04B18/24 , C04B26/006 , C04B26/28 , C08H8/00 , C08H99/00 , C08L91/00 , C09J191/00 , C09J199/00 , E01C7/262 , Y02W30/97
摘要： The invention relates to a viscoelastic material characterised in that it is produced by recovery of the hydrophobic phase obtained by a method of hydrothermal liquefaction from a biomass comprising at least one microalga and comprising at least 40 wt.% of water in relation to the total weight of the biomass, said hydrophobic phase comprising a viscoelastic oil and solid residues, wherein the quantity of solid residues amounts to between 15 wt.% and 30 wt.% of the total weight of the hydrophobic phase.
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5.发明授权
公开(公告)号：EP2117612B1
公开(公告)日：2015-07-29
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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公开(公告)号：EP3999136A1
公开(公告)日：2022-05-25
申请号：EP20740033.4
申请日：2020-07-17
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公开(公告)号：EP2117612B2
公开(公告)日：2018-11-21
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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公开(公告)号：EP1525210B1
公开(公告)日：2012-05-23
申请号：EP03750834.8
申请日：2003-07-22
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE NANTES , University of Florida
IPC分类号： C07H21/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00576 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00677 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C40B40/06 , C40B50/18 , G01N33/553
摘要： The invention concerns a method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by said method.
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公开(公告)号：EP2403544B1
公开(公告)日：2018-11-14
申请号：EP10706257.2
申请日：2010-03-03
发明人： BUJOLI, Bruno , BOULER, Jean-Michel , JANVIER, Pascal , KHAIROUN, Ibrahim , SCHNITZLER, Verena , MELLIER, Charlotte
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒCa (10.5-1.5x) Ga x (PO 4 ) 7 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein 0
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公开(公告)号：EP2403544A1
公开(公告)日：2012-01-11
申请号：EP10706257.2
申请日：2010-03-03
发明人： BUJOLI, Bruno , BOULER, Jean-Michel , JANVIER, Pascal , KHAIROUN, Ibrahim , SCHNITZLER, Verena , MELLIER, Charlotte
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒCa (10.5-1.5x) Ga x (PO 4 ) 7 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein 0
摘要翻译： 本发明涉及包含式（I）的掺杂镓的磷酸钙化合物的切片磷酸钙生物材料：€ƒ€ƒ€ƒ€ƒ€ƒCa（10.5-1.5x）Ga x（PO 4）其中0
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